Centromere protein S (CENPS) is a 138-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8N2Z9.
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The mean pLDDT of this model is 89.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT,…
Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners (PubMed:19620631, PubMed:20347428, PubMed:20347429, PubMed:24522885). MHF heterodimers can assemble to form tetrameric structures (PubMed:22304917). MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex (PubMed:22304917, PubMed:24522885). Forms a discrete…
Nucleus, Chromosome, centromere, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4NE3 | X-ray | 1.8 Å | A=14-105 |
| 4E45 | X-ray | 2.0 Å | A/C/F/H/K/M=1-110 |
| 4E44 | X-ray | 2.1 Å | A/C=1-110 |
| 4NE6 | X-ray | 2.1 Å | A/C=14-105 |
| 4DRA | X-ray | 2.41 Å | A/B/C/D=1-107 |
| 4NE5 | X-ray | 2.5 Å | A/C/E/G=14-105 |
| 4DRB | X-ray | 2.63 Å | A/B/D/E/G/H=1-114 |
| 7R5S | EM | 2.83 Å | S=1-138 |
| 7XHO | EM | 3.29 Å | S=1-138 |
| 7XHN | EM | 3.71 Å | S=1-138 |
| 4NE1 | X-ray | 6.5 Å | A/C/G/I/J/K/Q/R/S/T/Y/a/c/e/f/g/k/l/m/n=14-118 |
| 4NDY | X-ray | 7.0 Å | A/C/G/I/J/K/Q/R/S/T=14-105 |
| 7YWX | EM | 12.0 Å | S=1-138 |
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