Centromere protein X (CENPX) is a 81-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: A8MT69.
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The mean pLDDT of this model is 92.6 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 89% |
| 70 to 90 | Confident: backbone generally right | 3% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW…
Heterodimer with CENPX, sometimes called MHF; this interaction stabilizes both partners (PubMed:19620631, PubMed:20347428, PubMed:20347429, PubMed:24522885). MHF heterodimers can assemble to form tetrameric structures (PubMed:22304917). MHF also coassemble with CENPT-CENPW heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex (PubMed:22304917, PubMed:24522885). Forms a discrete…
Nucleus, Chromosome, centromere, Chromosome, centromere, kinetochore
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4NE3 | X-ray | 1.8 Å | B=8-81 |
| 4E45 | X-ray | 2.0 Å | B/D/G/I/L/N=1-81 |
| 4E44 | X-ray | 2.1 Å | B/D=1-81 |
| 4NE6 | X-ray | 2.1 Å | B/D=8-81 |
| 4DRA | X-ray | 2.41 Å | E/F/G/H=1-81 |
| 4NE5 | X-ray | 2.5 Å | B/D/F/H=8-81 |
| 4DRB | X-ray | 2.63 Å | J/K/L/M/N/O=1-81 |
| 7R5S | EM | 2.83 Å | X=1-81 |
| 7XHO | EM | 3.29 Å | X=1-81 |
| 7XHN | EM | 3.71 Å | X=1-81 |
| 4NE1 | X-ray | 6.5 Å | B/D/H/L/M/N/U/V/W/X/Z/b/d/h/i/j/o/p/q/r=8-81 |
| 4NDY | X-ray | 7.0 Å | B/D/H/L/M/N/U/V/W/X=8-81 |
| 7YWX | EM | 12.0 Å | X=1-81 |
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