4FDD: KAP beta2-PY-NLS

Crystal structure of KAP beta2-PY-NLS. Determined by X-ray diffraction at 2.3 Å resolution. Released 18 Jul 2012.

Method

X-ray diffraction

Resolution

2.3 Å

Organism

Homo sapiens

Chains

2

Atoms

6,969

Mol. weight

99.92 kDa

Released

18 Jul 2012

Explore 4FDD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4FDD contains 67 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 66 helices, 0 β-strands

Molecules and chains

>4FDD_1 Transportin-1 (chains A)
MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSE
DEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK
GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFL
QFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALV
MLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKL
IPVLVNGMKYSDIDIILLKGDVEGGSGGDDTISDWNLRKCSAAALDVLANVYRDELLPHI
LPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSIT
CWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPY
LAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKD
EDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDK
DFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKAC
FQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEII
NRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGIC
TMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPL
PLKERLAAFYGV

>4FDD_2 RNA-binding protein FUS (chains B)
RGGGDRGGFGPGKMDSRGEHRQDRRERPY

Primary citation

Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS). Zhang, Z.C., Chook, Y.M. Proc Natl Acad Sci U S A (2012) 109:12017-12021. DOI 10.1073/pnas.1207247109 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q92973 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 2Z5K 2.6 Å, Complex of Transportin 1 with TAP NLS
• 4OO6 2.7 Å, Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma…
• 7CYL 2.7 Å, Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
• 5YVI 2.9 Å, Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
• 1QBK 3.0 Å, Structure of the karyopherin BETA2-ran gppnhp nuclear transport complex
• 2QMR 3.0 Å, Karyopherin beta2/transportin
• 2Z5M 3.0 Å, Complex of Transportin 1 with TAP NLS, crystal form 2
• 4FQ3 3.0 Å, Crystal structure of transportin/FUS-NLS
• 5TQC 3.0 Å, Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of…
• 2H4M 3.05 Å, Karyopherin Beta2/Transportin-M9NLS
• 4JLQ 3.05 Å, Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces…
• 5J3V 3.05 Å, Crystal structure of human Karyopherin-beta2 bound to the histone H3 tail

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