4G82: P73 DNA-Binding Domain Tetramer

Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element. Determined by X-ray diffraction at 3.1 Å resolution. Released 16 Jan 2013.

Method: X-ray diffraction
Resolution: 3.1 Å
Organism: Homo sapiens
Chains: 4
Atoms: 3,576
Mol. weight: 53.77 kDa
Ligands: ZN
Released: 16 Jan 2013

Explore 4G82 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4G82 contains 8 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	121	1	1
β-strand	127-130	4	2
β-strand	142-145	4	1
β-strand	150-153	4	1
β-strand	158-165	8	2
β-strand	174-181	8	1
α-helix	184-187	4
β-strand	190	1	1
α-helix	191	1
α-helix	195-198	4
β-strand	215-218	4	2
β-strand	224-227	4	1
β-strand	234-239	6	1
β-strand	250-256	7	2
β-strand	271-278	8	1
β-strand	284-294	11	1
α-helix	298-311	14

Chain B: 4 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	121	1	3
β-strand	128-130	3	4
α-helix	132-135	4
β-strand	143-145	3	3
β-strand	150-153	4	3
β-strand	159-164	6	4
β-strand	174-181	8	3
β-strand	190	1	3
α-helix	191	1
α-helix	195-198	4
β-strand	215-217	3	4
β-strand	224-227	4	3
β-strand	234-239	6	3
β-strand	251-256	6	4
β-strand	271-278	8	3
β-strand	284-294	11	3
α-helix	298-310	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Tumor protein p73	A, B	protein	210	Homo sapiens	O15350 (AlphaFold model)
DNA (5'-d(pgpapapcpaptpgptptpc)-3')	E, F	DNA	10

Sequence of entity 1 (A, B), FASTA

>4G82_1 Tumor protein p73 (chains A, B)
MGHHHHHHHHEFIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQ
IKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNL
SQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDG
QVLGRRSFEGRICACPGRDRKADEDHYREQ

Sequence of entity 2 (E, F), FASTA

>4G82_2 DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3') (chains E, F)
GAACATGTTC

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	2

Primary citation

Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element. Ethayathulla, A.S., Viadiu, H. J Biol Chem (2013).

Other PDB entries of the same protein (UniProt O15350 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5HOB 1.22 Å, p73 homo-tetramerization domain mutant I
5HOC 1.36 Å, p73 homo-tetramerization domain mutant II
2WQI 1.7 Å, Crystal structure of the human p73 tetramerization domain
8P9C 1.76 Å, Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with…
9GNB 1.8 Å, Structure of p73 SAM domain in complex with DARPin B9
2XWC 1.82 Å, Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution
2WQJ 2.0 Å, Crystal structure of a truncated variant of the human p73 tetramerization domain
9GLQ 2.1 Å, Crystal structure of p73 tetramerisation domain in complex with darpins 1800
8P9E 2.25 Å, Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in…
4A63 2.27 Å, Crystal structure of the p73-ASPP2 complex at 2.6A resolution
2WTT 2.3 Å, Structure of the human p73 tetramerization domain (crystal form II)
1DXS 2.54 Å, Crystal structure of the C-terminal sterile alpha motif (SAM) domain of human p73 alpha…

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