Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in complex with phosphorylated Syndecan1 Peptide. Determined by X-ray diffraction at 1.54 Å resolution. Released 13 Mar 2013.
Explore 4GVC in 3D Show helices and sheets RCSB PDB PDBe
4GVC contains 4 α-helices and 7 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 843-849 | 7 | 1 |
| β-strand | 860-867 | 8 | 1 |
| β-strand | 870-878 | 9 | 1 |
| α-helix | 883-886 | 4 | |
| α-helix | 893 | 1 | |
| β-strand | 894-898 | 5 | 1 |
| β-strand | 901-902 | 2 | 1 |
| α-helix | 903-905 | 3 | |
| α-helix | 908-915 | 8 | |
| β-strand | 919-925 | 7 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-7 | 4 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| T-lymphoma invasion and metastasis-inducing protein 1 | A | protein | 94 | Homo sapiens | Q13009 (AlphaFold model) |
| Syndecan-1 | B | protein | 8 | Homo sapiens | P18827 (AlphaFold model) |
>4GVC_1 T-lymphoma invasion and metastasis-inducing protein 1 (chains A) GAMGKVTHSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASKKGLKAGDEIL EINNRAADALNSSMLKDFLSQPSLGLLVRTYPEL
>4GVC_2 Syndecan-1 (chains B) TKQEEFYA
| ID | Name | Formula | Copies |
|---|---|---|---|
| ANS | 5-(dimethylamino)-1-naphthalenesulfonic acid(dansyl acid) | C12 H13 N O3 S | 1 |
Water and common crystallization additives (NA, CL) are not listed.
The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Liu, X., Shepherd, T.R., Murray, A.M. et al. Structure (2013) 21:342-354. DOI 10.1016/j.str.2013.01.004 · PubMed
Other PDB entries of the same protein (UniProt Q13009 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 4GVC directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.