4JLQ: Human Karyopherin-beta2

Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2. Determined by X-ray diffraction at 3.05 Å resolution. Released 3 Apr 2013.

Method

X-ray diffraction

Resolution

3.05 Å

Organisms

Homo sapiens, Saccharomyces cerevisiae S288c

Chains

2

Atoms

6,733

Mol. weight

100.79 kDa

Released

3 Apr 2013

Explore 4JLQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4JLQ contains 64 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 64 helices, 0 β-strands

Molecules and chains

>4JLQ_1 Transportin-1 (chains A)
MEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSE
DEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASK
GELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFL
QFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALV
MLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKL
IPVLVNGMKYSDIDIILLKGDVEGGSGGSGDDTISDWNLRKCSAAALDVLANVYRDELLP
HILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRS
ITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELV
PYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNML
KDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAP
DKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTK
ACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVE
IINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRG
ICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQF
PLPLKERLAAFYGV

>4JLQ_2 Nuclear polyadenylated RNA-binding protein NAB2 (chains B)
RFTQRGGGAVGKNRRGGRGGNRGGRNNNSTRFNPLAKA

Primary citation

Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2. Soniat, M., Sampathkumar, P., Collett, G. et al. J Struct Funct Genomics (2013) 14:31-35. DOI 10.1007/s10969-013-9150-1 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q92973 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4FDD 2.3 Å, Crystal structure of KAP beta2-PY-NLS
• 2Z5K 2.6 Å, Complex of Transportin 1 with TAP NLS
• 4OO6 2.7 Å, Crystal structure of human KAP-beta2 bound to the NLS of HCC1 (Hepato Cellular Carcinoma…
• 7CYL 2.7 Å, Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
• 5YVI 2.9 Å, Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
• 1QBK 3.0 Å, Structure of the karyopherin BETA2-ran gppnhp nuclear transport complex
• 2QMR 3.0 Å, Karyopherin beta2/transportin
• 2Z5M 3.0 Å, Complex of Transportin 1 with TAP NLS, crystal form 2
• 4FQ3 3.0 Å, Crystal structure of transportin/FUS-NLS
• 5TQC 3.0 Å, Crystal structure of transport factor karyopherin-beta 2 in complex with the PY-NLS of…
• 2H4M 3.05 Å, Karyopherin Beta2/Transportin-M9NLS
• 5J3V 3.05 Å, Crystal structure of human Karyopherin-beta2 bound to the histone H3 tail

Browse structure collections

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