4JO7: Nucleoporin p54

Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex with 2:2 stoichiometry. Determined by X-ray diffraction at 1.75 Å resolution. Released 17 Sept 2014.

Method: X-ray diffraction
Resolution: 1.75 Å
Organism: Homo sapiens
Chains: 8
Atoms: 4,592
Mol. weight: 61.01 kDa
Released: 17 Sept 2014

Explore 4JO7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4JO7 contains 12 α-helices and 0 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	329-356	28
α-helix	370-412	43

Chains B, D, F and H: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	457-487	31

Chain C: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	333-356	24
α-helix	370-412	43

Chain E: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	333-359	27
α-helix	370-412	43

Chain G: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	329-358	30
α-helix	370-412	43

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Nucleoporin p54	B, D, F, H	protein	40	Homo sapiens	Q7Z3B4 (AlphaFold model)
Nucleoporin p58/p45	A, C, E, G	protein	89	Homo sapiens	Q9BVL2 (AlphaFold model)

Sequence of entity 1 (B, D, F, H), FASTA

>4JO7_1 Nucleoporin p54 (chains B, D, F, H)
SYYIDADLLREIKQHLKQQQEGLSHLISIIKDDLEDIKLV

Sequence of entity 2 (A, C, E, G), FASTA

>4JO7_2 Nucleoporin p58/p45 (chains A, C, E, G)
SAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVAL
AAQLQSIHENVKVLKEQYLGYRKMFLGDA

Primary citation

Architecture of the fungal nuclear pore inner ring complex. Stuwe, T., Bley, C.J., Thierbach, K. et al. Science (2015) 350:56-64. DOI 10.1126/science.aac9176 · PubMed

Other PDB entries of the same protein (UniProt Q7Z3B4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7N8R 1.2 Å, FGTGFG segment from the Nucleoporin p54, residues 63-68
4JNU 1.45 Å, Crystal structure of the human Nup57CCS3* coiled-coil segment, space group P21
4JNV 1.85 Å, Crystal structure of the human Nup57CCS3* coiled-coil segment, space group C2
4JO9 2.5 Å, Crystal structure of the human Nup49CCS2+3* Nup57CCS3* complex 1:2 stoichiometry
7R5K 12.0 Å, Human nuclear pore complex (constricted)
5IJN 21.4 Å, Composite structure of the inner ring of the human nuclear pore complex (32 copies of…
5IJO 21.4 Å, Alternative composite structure of the inner ring of the human nuclear pore complex (16…
7PER 35.0 Å, Model of the inner ring of the human nuclear pore complex
7R5J 50.0 Å, Human nuclear pore complex (dilated)
9A25 Molecular assembly pathway of the human Nuclear Pore Complex after cell division
9A8T Integrative spatiotemporal modeling of biomolecular processes: application to the…

Browse structure collections

About this viewer

MolViewer shows 4JO7 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.