Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Determined by X-ray diffraction at 3.0 Å resolution. Released 8 May 2013.
Explore 4K2R in 3D Show helices and sheets RCSB PDB PDBe
4K2R contains 24 α-helices and 28 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 11 | 1 | 1 |
| β-strand | 13 | 1 | 2 |
| α-helix | 17-26 | 10 | |
| β-strand | 33-38 | 6 | 1 |
| β-strand | 42 | 1 | 3 |
| β-strand | 46-52 | 7 | 1 |
| β-strand | 55-63 | 9 | 1 |
| β-strand | 69-71 | 3 | 1 |
| β-strand | 77 | 1 | 1 |
| α-helix | 80-89 | 10 | |
| β-strand | 100-101 | 2 | 1 |
| α-helix | 103-105 | 3 | |
| α-helix | 110 | 1 | |
| β-strand | 111 | 1 | 2 |
| α-helix | 112 | 1 | |
| α-helix | 114-130 | 17 | |
| α-helix | 136-155 | 20 | |
| α-helix | 158-160 | 3 | |
| β-strand | 164 | 1 | 4 |
| α-helix | 170-179 | 10 | |
| β-strand | 187-191 | 5 | 4 |
| β-strand | 198-204 | 7 | 4 |
| β-strand | 207-213 | 7 | 4 |
| β-strand | 214-215 | 2 | 3 |
| β-strand | 221-222 | 2 | 3 |
| β-strand | 228-229 | 2 | 3 |
| α-helix | 232-239 | 8 | |
| β-strand | 253 | 1 | 4 |
| α-helix | 309-311 | 3 | |
| α-helix | 318-320 | 3 | |
| α-helix | 322-326 | 5 | |
| β-strand | 331 | 1 | 5 |
| α-helix | 332-333 | 2 | |
| α-helix | 334-336 | 3 | |
| β-strand | 337-346 | 10 | 5 |
| β-strand | 350-358 | 9 | 5 |
| β-strand | 363-371 | 9 | 5 |
| α-helix | 380-390 | 11 | |
| β-strand | 398 | 1 | 6 |
| β-strand | 401-406 | 6 | 5 |
| β-strand | 410-415 | 6 | 5 |
| β-strand | 421 | 1 | 6 |
| α-helix | 422-426 | 5 | |
| α-helix | 435-454 | 20 | |
| α-helix | 464-466 | 3 | |
| β-strand | 467-471 | 5 | 6 |
| β-strand | 474-477 | 4 | 6 |
| α-helix | 508-513 | 6 | |
| α-helix | 518-533 | 16 | |
| α-helix | 546-553 | 8 | |
| α-helix | 566-574 | 9 | |
| α-helix | 586-601 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tyrosine-protein kinase ZAP-70 | A | protein | 614 | Homo sapiens | P43403 (AlphaFold model) |
>4K2R_1 Tyrosine-protein kinase ZAP-70 (chains A) MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYAKISDF GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL ASKVEGGSGLEVLF
| ID | Name | Formula | Copies |
|---|---|---|---|
| PO4 | Phosphate ion | O4 P | 1 |
| ANP | Phosphoaminophosphonic acid-adenylate ester | C10 H17 N6 O12 P3 | 1 |
| MG | Magnesium ion | Mg | 1 |
Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker. Yan, Q., Barros, T., Visperas, P.R. et al. Mol Cell Biol (2013) 33:2188-2201. DOI 10.1128/MCB.01637-12 · PubMed
Other PDB entries of the same protein (UniProt P43403 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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