4L8U: X-ray study of human serum albumin

X-ray study of human serum albumin complexed with 9 amino camptothecin. Determined by X-ray diffraction at 2.01 Å resolution. Released 24 Jul 2013.

Method: X-ray diffraction
Resolution: 2.01 Å
Organism: Homo sapiens
Chains: 1
Atoms: 5,171
Mol. weight: 68.09 kDa
Ligands: MYR, 9AZ
Released: 24 Jul 2013

Explore 4L8U in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4L8U contains 37 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 0 β-strands

Element	Residues	Length
α-helix	6-14	9
α-helix	16-30	15
α-helix	36-55	20
α-helix	66-74	9
α-helix	80-84	5
α-helix	85-92	8
α-helix	95-104	10
α-helix	112-115	4
α-helix	120-129	10
α-helix	131-145	15
α-helix	151-168	18
α-helix	174-222	49
α-helix	228-247	20
α-helix	250-266	17
α-helix	268-270	3
α-helix	276-280	5
α-helix	283-291	9
α-helix	293-299	7
α-helix	302-304	3
α-helix	306	1
α-helix	307-311	5
α-helix	315-321	7
α-helix	323-336	14
α-helix	343-360	18
α-helix	366-370	5
α-helix	373-414	42
α-helix	420-437	18
α-helix	442-466	25
α-helix	471-478	8
α-helix	481-489	9
α-helix	491-493	3
α-helix	497-502	6
α-helix	505-507	3
α-helix	511-514	4
α-helix	518-535	18
α-helix	541-559	19
α-helix	566-582	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Serum albumin	A	protein	585	Homo sapiens	P02768 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4L8U_1 Serum albumin (chains A)
DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAE
NCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEV
DVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLP
KLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTK
VHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPA
DLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKC
CAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVST
PTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTES
LVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKAT
KEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL

Ligands and cofactors

ID	Name	Formula	Copies
MYR	Myristic acid	C14 H28 O2	5
9AZ	(2S)-2-[1-amino-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7…	C20 H19 N3 O5	1

Primary citation

Structural studies of several clinically important oncology drugs in complex with human serum albumin. Wang, Z.M., Ho, J.X., Ruble, J.R. et al. Biochim Biophys Acta (2013) 1830:5356-5374. DOI 10.1016/j.bbagen.2013.06.032 · PubMed

Other PDB entries of the same protein (UniProt P02768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9IK6 1.69 Å, Human Serum Albumin crystallized with T4, pH 6.5
6YG9 1.89 Å, Crystal structure of human serum albumin (HSA) in complex with gn-07.
1N5U 1.9 Å, X-ray study of human serum albumin complexed with heme
8RCO 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution
8RCP 1.9 Å, Structure of Human Serum Albumin in complex with Myristic Acid
8RGK 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution
8RGL 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid I at 1.9 A resolution…
9EOD 1.9 Å, Human serum albumin with adamantene carboxylic acid
9CSG 1.91 Å, Human Serum Albumin Bound to Cerastecin Compound 5e
6QIO 1.95 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
9IK7 1.97 Å, Human Serum Albumin crystallized with T4, pH 7.5
7VR0 1.98 Å, Human Serum Albumin

Browse structure collections

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