NS2B-NS3 protease from dengue virus at pH 8.5. Determined by X-ray diffraction at 1.53 Å resolution. Released 27 Nov 2013.
Explore 4M9M in 3D Show helices and sheets RCSB PDB PDBe
4M9M contains 4 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 51-57 | 7 | 1 |
| α-helix | 63-68 | 6 | |
| β-strand | 70-72 | 3 | 2 |
| β-strand | 1021-1029 | 9 | 1 |
| β-strand | 1032-1042 | 11 | 1 |
| β-strand | 1045-1049 | 5 | 1 |
| α-helix | 1050-1053 | 4 | |
| β-strand | 1058-1060 | 3 | 1 |
| β-strand | 1063-1065 | 3 | 1 |
| β-strand | 1067-1071 | 5 | 1 |
| β-strand | 1076-1079 | 4 | 1 |
| β-strand | 1095-1099 | 5 | 2 |
| β-strand | 1107-1111 | 5 | 2 |
| α-helix | 1113 | 1 | |
| β-strand | 1114-1118 | 5 | 3 |
| β-strand | 1121-1126 | 6 | 3 |
| α-helix | 1132-1134 | 3 | |
| β-strand | 1138-1140 | 3 | 2 |
| β-strand | 1146-1149 | 4 | 2 |
| β-strand | 1153-1155 | 3 | 3 |
| β-strand | 1161-1164 | 4 | 3 |
| β-strand | 1170 | 1 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| NS2B-NS3 protease | A | protein | 247 | Dengue virus 2 | P12823 |
>4M9M_1 NS2B-NS3 protease (chains A) GSHMLEADLELERAADVRWEEQAEISGSSPILSITISEDGSMSIKNEEEEQTLGGGGSGG GGAGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVL MHKGKRIEPSWADVKKDLISYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQTKPGLFKT NTGTIGAVSLDFSPGTSGSPIVDKKGKVVGLYGNGVVTRSGAYVSAIANTEKSIEDNPEI EDDIFRK
Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus. Yildiz, M., Ghosh, S., Bell, J.A. et al. ACS Chem Biol (2013) 8:2744-2752. DOI 10.1021/cb400612h · PubMed
Other PDB entries of the same protein (UniProt P12823), best resolution first:
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