4XES: Active-like neurotensin receptor

Structure of active-like neurotensin receptor. Determined by X-ray diffraction at 2.6 Å resolution. Released 29 Jul 2015.

Method: X-ray diffraction
Resolution: 2.6 Å
Organisms: Rattus norvegicus, Enterobacteria phage T4
Chains: 2
Atoms: 3,923
Mol. weight: 62.98 kDa
Ligands: CIT
Released: 29 Jul 2015

Explore 4XES in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4XES contains 27 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 27 helices, 8 β-strands

Element	Residues	Length	Sheet
α-helix	61-92	32
α-helix	97-119	23
α-helix	121-123	3
α-helix	124-130	7
α-helix	138-172	35
α-helix	174-180	7
α-helix	183-200	18
α-helix	203-207	5
β-strand	208-212	5	1
α-helix	220-222	3
β-strand	223-227	5	1
α-helix	231-242	12
α-helix	243-247	5
α-helix	248-267	20
α-helix	298-300	3
α-helix	301-333	33
α-helix	336-338	3
α-helix	341-368	28
α-helix	376-381	6
α-helix	1003-1010	8
β-strand	1014-1015	2	2
β-strand	1016	1	3
β-strand	1017-1019	3	2
β-strand	1025-1028	4	2
β-strand	1031-1032	2	2
α-helix	1039-1050	12
β-strand	1057	1	3
α-helix	1060-1079	20
α-helix	1085-1089	5
α-helix	1093-1106	14
α-helix	1108-1111	4
α-helix	1115-1122	8
α-helix	1126-1133	8
α-helix	1137-1141	5
α-helix	1143-1155	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neurotensin receptor type 1, Endolysin chimera	A	protein	541	Rattus norvegicus, Enterobacteria phage T4	P00720, P20789 (AlphaFold model)
Neurotensin/neuromedin N	B	protein	6	Rattus norvegicus	P20068 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4XES_1 Neurotensin receptor type 1, Endolysin chimera (chains A)
DYKDDDDATSTSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARK
KSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDAC
TYATALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQN
RSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAA
EQGRVCTVGTHNGLEHSTFNMTIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFC
YISDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANFRQVFLSTLACLCPGWR
HRRKAHHHHHHHHHHGGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKS
ELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVF
QMGETGVAGFTNSLRMLNNKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYGSG
S

Sequence of entity 2 (B), FASTA

>4XES_2 Neurotensin/neuromedin N (chains B)
RRPYIL

Ligands and cofactors

ID	Name	Formula	Copies
CIT	Citric acid	C6 H8 O7	1

Water and common crystallization additives (EPE, GOL, PEG) are not listed.

Primary citation

Structural prerequisites for G-protein activation by the neurotensin receptor. Krumm, B.E., White, J.F., Shah, P. et al. Nat Commun (2015) 6:7895-7895. DOI 10.1038/ncomms8895 · PubMed

Other PDB entries of the same protein (UniProt P00720), best resolution first:

2O7A 0.84 Å, T4 lysozyme C-terminal fragment
5JDT 1.0 Å, Structure of Spin-labelled T4 lysozyme mutant L118C-R1 at 100K
7LOE 1.01 Å, T4 lysozyme mutant L99A in complex with 1-fluoranylnaphthalene
7LOD 1.02 Å, T4 lysozyme mutant L99A in complex with 1-fluoranyl-4-iodanyl-benzene
7LX8 1.03 Å, T4 lysozyme mutant L99A
5XPF 1.04 Å, High-resolution X-ray structure of the T26H mutant of T4 lysozyme
6BG3 1.05 Å, Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl…
7LOF 1.05 Å, T4 lysozyme mutant L99A in complex with 2-butylthiophene
7LX6 1.05 Å, T4 lysozyme mutant L99A
7LX7 1.05 Å, T4 lysozyme mutant L99A
1SWY 1.06 Å, Use of a Halide Binding Site to Bypass the 1000-atom Limit to Ab initio Structure…
1SWZ 1.06 Å, Use of an ion-binding site to bypass the 1000-atom limit to ab initio structure…

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