Neurotensin receptor type 1 (Ntsr1) is a 424-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P20789.
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The mean pLDDT of this model is 78.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 18% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
G protein-coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity)
Interacts (palmitoylated form) with GNA11
Cell membrane, Membrane raft
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6YVR | X-ray | 2.46 Å | AAA/BBB=50-371 |
| 8FMZ | EM | 2.59 Å | A=43-420 |
| 4XES | X-ray | 2.6 Å | A=43-396 |
| 6Z4V | X-ray | 2.6 Å | AAA=50-371 |
| 6ZIN | X-ray | 2.64 Å | AAA=50-371 |
| 6Z4S | X-ray | 2.71 Å | AAA=50-371 |
| 6ZA8 | X-ray | 2.72 Å | AAA=50-371 |
| 4BUO | X-ray | 2.75 Å | A/B=50-390 |
| 4GRV | X-ray | 2.8 Å | A=43-268, A=300-396 |
| 6Z8N | X-ray | 2.8 Å | AAA=50-371 |
| 8FN1 | EM | 2.88 Å | A=39-424 |
| 8FN0 | EM | 2.89 Å | A=43-424 |
| 4XEE | X-ray | 2.9 Å | A=43-396 |
| 6Z4Q | X-ray | 2.92 Å | AAA=50-371 |
| 3ZEV | X-ray | 3.0 Å | A/B=50-390 |
| 4BV0 | X-ray | 3.1 Å | A/B=50-390 |
| 9QD4 | X-ray | 3.11 Å | A=50-371 |
| 9QC1 | X-ray | 3.12 Å | A=50-371 |
| 6Z66 | X-ray | 3.19 Å | AAA=50-371 |
| 5T04 | X-ray | 3.3 Å | A=43-268, A=297-396 |
Showing 20 of 25 experimental structures (best resolution first).
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