4Y99: Core domain of human cardiac troponin

Core domain of human cardiac troponin. Determined by X-ray diffraction at 2.0 Å resolution. Released 30 Mar 2016.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Homo sapiens
Chains: 3
Atoms: 2,998
Mol. weight: 55.83 kDa
Ligands: CA
Released: 30 Mar 2016

Explore 4Y99 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4Y99 contains 18 α-helices and 4 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	3-10	8
α-helix	14-28	15
β-strand	36	1	1
α-helix	38-47	10
α-helix	54-62	9
β-strand	72	1	1
α-helix	74-83	10
α-helix	94-104	11
β-strand	111-112	2	2
α-helix	114-123	10
α-helix	130-140	11
β-strand	148-149	2	2
α-helix	150-157	8

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	200-215	16
α-helix	216-218	3
α-helix	226-270	45

Chain C: 6 helices, 0 β-strands

Element	Residues	Length
α-helix	35-37	3
α-helix	43-79	37
α-helix	81-83	3
α-helix	90-136	47
α-helix	151-159	9
α-helix	160-162	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Troponin C, slow skeletal and cardiac muscles	A	protein	161	Homo sapiens	P63316 (AlphaFold model)
Troponin T, cardiac muscle	B	protein	106	Homo sapiens	P45379 (AlphaFold model)
Troponin I, cardiac muscle	C	protein	210	Homo sapiens	P19429 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4Y99_1 Troponin C, slow skeletal and cardiac muscles (chains A)
MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGSISTKELGKVMRMLGQNPTPEELQEM
IDEVDEDGSGTVDFDEFLVMMVRSMKDDSKGKSEEELSDLFRMFDKNADGYIDLEELKIM
LQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE

Sequence of entity 2 (B), FASTA

>4Y99_2 Troponin T, cardiac muscle (chains B)
HFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQTIYN
LEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK

Sequence of entity 3 (C), FASTA

>4Y99_3 Troponin I, cardiac muscle (chains C)
MADGSSDAAREPRPAPAPIRRRSSNYRAYATEPHAKKKSKISASRKLQLKTLLLQIAKQE
LEREAEERRGEKGRALSTRAQPLELAGLGFAELQDLARQLHARVDKVDEERYDIEAKVTK
NITEIADLTQKIFDLRGKFKRPTLRRVRISADAMMQALLGARAKESLDLRAHLKQVKKED
TEKENREVGDWRKNIDALSGMEGRKKKFES

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	3

Water and common crystallization additives (DMS) are not listed.

Primary citation

Core domain of human cardiac troponin. Takeda, S., Fujiwara, S. To be published.

Other PDB entries of the same protein (UniProt P63316 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3SD6 1.37 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C in complex…
4GJE 1.6 Å, Crystal structure of the refolded amino-terminal domain of human cardiac troponin C in…
3SWB 1.67 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C in complex…
7SC2 1.81 Å, Crystal structure of the N-domain of cardiac muscle troponin C tethered to the switch…
4GJF 1.9 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C mutant L29Q…
4GJG 2.0 Å, Crystal structure of the amino-terminal domain of human cardiac troponin C mutant…
1WRK 2.15 Å, Crystal structure of the N-terminal domain of human cardiac troponin C in complex with…
3RV5 2.2 Å, Crystal structure of human cardiac troponin C regulatory domain in complex with cadmium…
7SC3 2.23 Å, Crystal structure of the N-domain of cardiac muscle troponin C tethered to the switch…
1WRL 2.6 Å, Crystal structure of the N-terminal domain of human cardiac troponin C in complex with…
1J1D 2.61 Å, Crystal structure of the 46kDa domain of human cardiac troponin in the Ca2+ saturated form
8FMO 2.61 Å, Complex structure of K210 deletion Troponin complex with risedronate

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