Structure of an APC2-UBCH10 complex reveals distinctive cullin-RING ligase mechanism for Anaphase-promoting complex/Cyclosome. Determined by X-ray diffraction at 1.8 Å resolution. Released 8 Apr 2015.
Explore 4YII in 3D Show helices and sheets RCSB PDB PDBe
4YII contains 11 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 748-765 | 18 | |
| β-strand | 768 | 1 | 4 |
| α-helix | 770-777 | 8 | |
| α-helix | 778-782 | 5 | |
| α-helix | 792-804 | 13 | |
| β-strand | 809-811 | 3 | 4 |
| β-strand | 814-816 | 3 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 30-45 | 16 | |
| β-strand | 50-54 | 5 | 1 |
| β-strand | 61-67 | 7 | 1 |
| β-strand | 68 | 1 | 2 |
| α-helix | 69 | 1 | |
| β-strand | 75 | 1 | 2 |
| β-strand | 78-84 | 7 | 1 |
| α-helix | 93-94 | 2 | |
| β-strand | 95-98 | 4 | 1 |
| β-strand | 107 | 1 | 3 |
| β-strand | 112 | 1 | 1 |
| β-strand | 113 | 1 | 3 |
| α-helix | 116-118 | 3 | |
| α-helix | 128-140 | 13 | |
| α-helix | 150-155 | 6 | |
| α-helix | 159-172 | 14 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ubiquitin-conjugating enzyme E2 C | U | protein | 155 | Homo sapiens | O00762 (AlphaFold model) |
| Anaphase-promoting complex subunit 2 | A | protein | 90 | Homo sapiens | Q9UJX6 (AlphaFold model) |
>4YII_1 Ubiquitin-conjugating enzyme E2 C (chains U) GSARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLE FPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNI DSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
>4YII_2 Anaphase-promoting complex subunit 2 (chains A) GSESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEIDL QELQGYLQKKVRDQQLVYSAGVYRLPKNCS
Crystal Structure of E2 Complex. Brown, N.G., Cho, S.E., Schulman, B.A. Proc Natl Acad Sci U S A (2015).
Other PDB entries of the same protein (UniProt O00762 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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