9GAW: Anaphase-promoting complex/cyclosome
High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1. Determined by electron microscopy at 2.9 Å resolution. Released 14 Aug 2024.
- Method
- Electron microscopy
- Resolution
- 2.9 Å
- Organism
- Homo sapiens
- Chains
- 21
- Atoms
- 66,640
- Mol. weight
- 1279.09 kDa
- Ligands
- ZN
- Released
- 14 Aug 2024
Explore 9GAW in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9GAW contains 477 α-helices and 164 β-strands across 21 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 91 helices, 54 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-13 | 3 | 7 |
| β-strand | 17-19 | 3 | 8 |
| α-helix | 23-29 | 7 | |
| α-helix | 42-46 | 5 | |
| β-strand | 72-78 | 7 | 9 |
| β-strand | 90-96 | 7 | 9 |
| β-strand | 99-104 | 6 | 9 |
| β-strand | 112-118 | 7 | 9 |
| β-strand | 123-132 | 10 | 10 |
| α-helix | 144-146 | 3 | |
| β-strand | 147-155 | 9 | 10 |
| β-strand | 158-163 | 6 | 10 |
| β-strand | 168-172 | 5 | 10 |
| β-strand | 177-182 | 6 | 11 |
| β-strand | 187-191 | 5 | 11 |
| α-helix | 192-193 | 2 | |
| β-strand | 210-213 | 4 | 11 |
| α-helix | 219-220 | 2 | |
| β-strand | 221-222 | 2 | 11 |
| β-strand | 223-226 | 4 | 12 |
| β-strand | 237-238 | 2 | 12 |
| β-strand | 244-249 | 6 | 12 |
| β-strand | 255-260 | 6 | 12 |
| β-strand | 265-273 | 9 | 12 |
| α-helix | 274-275 | 2 | |
| α-helix | 276-282 | 7 | |
| β-strand | 407-414 | 8 | 12 |
| α-helix | 415-417 | 3 | |
| β-strand | 430-434 | 5 | 13 |
| β-strand | 440-446 | 7 | 13 |
| β-strand | 451-459 | 9 | 13 |
| β-strand | 466-475 | 10 | 13 |
| β-strand | 478-482 | 5 | 7 |
| β-strand | 487-491 | 5 | 7 |
| β-strand | 497-501 | 5 | 7 |
| β-strand | 504-510 | 7 | 7 |
| β-strand | 584-591 | 8 | 8 |
| β-strand | 594-599 | 6 | 8 |
| β-strand | 604-608 | 5 | 8 |
| α-helix | 609-611 | 3 | |
| α-helix | 616-628 | 13 | |
| α-helix | 631-645 | 15 | |
| α-helix | 656-666 | 11 | |
| α-helix | 676-679 | 4 | |
| α-helix | 704-711 | 8 | |
| α-helix | 714-721 | 8 | |
| α-helix | 725-728 | 4 | |
| α-helix | 730-732 | 3 | |
| β-strand | 748 | 1 | 14 |
| α-helix | 756-758 | 3 | |
| α-helix | 759-773 | 15 | |
| α-helix | 777-779 | 3 | |
| α-helix | 782-796 | 15 | |
| α-helix | 800-809 | 10 | |
| α-helix | 819-821 | 3 | |
| β-strand | 822 | 1 | 14 |
| α-helix | 825-828 | 4 | |
| α-helix | 841-842 | 2 | |
| α-helix | 844-853 | 10 | |
| α-helix | 858-859 | 2 | |
| β-strand | 860-862 | 3 | 15 |
| α-helix | 868-880 | 13 | |
| α-helix | 885-889 | 5 | |
| β-strand | 896-898 | 3 | 15 |
| α-helix | 926-937 | 12 | |
| α-helix | 941-946 | 6 | |
| α-helix | 953-964 | 12 | |
| α-helix | 972-978 | 7 | |
| α-helix | 981-983 | 3 | |
| α-helix | 1021-1027 | 7 | |
| β-strand | 1031 | 1 | 16 |
| α-helix | 1033-1041 | 9 | |
| α-helix | 1046 | 1 | |
| β-strand | 1047-1048 | 2 | 17 |
| α-helix | 1059-1077 | 19 | |
| α-helix | 1080-1087 | 8 | |
| α-helix | 1099-1101 | 3 | |
| β-strand | 1109-1111 | 3 | 17 |
| β-strand | 1116-1118 | 3 | 17 |
| α-helix | 1133-1145 | 13 | |
| α-helix | 1155-1160 | 6 | |
| α-helix | 1169-1182 | 14 | |
| α-helix | 1184-1187 | 4 | |
| α-helix | 1190-1199 | 10 | |
| α-helix | 1202-1216 | 15 | |
| α-helix | 1222-1229 | 8 | |
| α-helix | 1237 | 1 | |
| α-helix | 1247-1260 | 14 | |
| α-helix | 1267-1277 | 11 | |
| α-helix | 1291-1306 | 16 | |
| α-helix | 1321-1330 | 10 | |
| β-strand | 1352-1353 | 2 | 2 |
| α-helix | 1360-1374 | 15 | |
| α-helix | 1381-1385 | 5 | |
| α-helix | 1389-1390 | 2 | |
| α-helix | 1393-1396 | 4 | |
| α-helix | 1401-1414 | 14 | |
| α-helix | 1423-1428 | 6 | |
| α-helix | 1432-1437 | 6 | |
| α-helix | 1454-1475 | 22 | |
| β-strand | 1481 | 1 | 18 |
| α-helix | 1482-1499 | 18 | |
| α-helix | 1504-1507 | 4 | |
| α-helix | 1509-1526 | 18 | |
| α-helix | 1533-1544 | 12 | |
| α-helix | 1552-1565 | 14 | |
| α-helix | 1567-1570 | 4 | |
| β-strand | 1572-1574 | 3 | 19 |
| α-helix | 1578-1587 | 10 | |
| α-helix | 1604-1613 | 10 | |
| β-strand | 1614-1616 | 3 | 19 |
| β-strand | 1618-1619 | 2 | 20 |
| β-strand | 1620-1623 | 4 | 21 |
| β-strand | 1628-1629 | 2 | 21 |
| β-strand | 1632-1638 | 7 | 22 |
| α-helix | 1639-1640 | 2 | |
| β-strand | 1647-1653 | 7 | 22 |
| β-strand | 1655-1656 | 2 | 20 |
| α-helix | 1657-1659 | 3 | |
| α-helix | 1660-1662 | 3 | |
| β-strand | 1663-1667 | 5 | 22 |
| β-strand | 1673 | 1 | 23 |
| β-strand | 1677-1679 | 3 | 22 |
| α-helix | 1685-1692 | 8 | |
| β-strand | 1696-1699 | 4 | 21 |
| β-strand | 1701 | 1 | 23 |
| α-helix | 1702 | 1 | |
| α-helix | 1726-1732 | 7 | |
| α-helix | 1735-1740 | 6 | |
| α-helix | 1745-1750 | 6 | |
| α-helix | 1751-1755 | 5 | |
| α-helix | 1764-1780 | 17 | |
| α-helix | 1784-1786 | 3 | |
| α-helix | 1787-1801 | 15 | |
| α-helix | 1809-1820 | 12 | |
| α-helix | 1825-1829 | 5 | |
| α-helix | 1844-1859 | 16 | |
| α-helix | 1860-1864 | 5 | |
| α-helix | 1865-1873 | 9 | |
| α-helix | 1879-1881 | 3 | |
| α-helix | 1882-1892 | 11 | |
| α-helix | 1894-1896 | 3 | |
| α-helix | 1897-1899 | 3 | |
| α-helix | 1911-1919 | 9 | |
| α-helix | 1925-1935 | 11 | |
Chain C: 1 helix, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-8 | 2 | 24 |
| β-strand | 12-14 | 3 | 25 |
| β-strand | 22 | 1 | 48 |
| β-strand | 29 | 1 | 48 |
| β-strand | 46-48 | 3 | 49 |
| β-strand | 49 | 1 | 50 |
| β-strand | 54-56 | 3 | 49 |
| α-helix | 57-67 | 11 | |
| β-strand | 72 | 1 | 51 |
| β-strand | 79 | 1 | 51 |
| β-strand | 82 | 1 | 50 |
Chain D: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| α-helix | 28-45 | 18 | |
Chain G: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-7 | 4 | |
| α-helix | 13-15 | 3 | |
| α-helix | 16-25 | 10 | |
Chain H: 5 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 52-83 | 32 | |
| α-helix | 84-86 | 3 | |
| α-helix | 87-91 | 5 | |
| α-helix | 93-95 | 3 | |
| α-helix | 99-102 | 4 | |
Chain I: 26 helices, 32 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-18 | 7 | 27 |
| α-helix | 22 | 1 | |
| β-strand | 23-28 | 6 | 28 |
| β-strand | 34-39 | 6 | 28 |
| β-strand | 44-48 | 5 | 28 |
| α-helix | 50-52 | 3 | |
| β-strand | 54-58 | 5 | 28 |
| β-strand | 71-73 | 3 | 29 |
| β-strand | 79-84 | 6 | 29 |
| β-strand | 89-94 | 6 | 29 |
| β-strand | 100-105 | 6 | 29 |
| β-strand | 112-117 | 6 | 30 |
| α-helix | 143-145 | 3 | |
| α-helix | 161-169 | 9 | |
| β-strand | 174-179 | 6 | 30 |
| β-strand | 185-189 | 5 | 30 |
| β-strand | 193-198 | 6 | 30 |
| β-strand | 204-210 | 7 | 31 |
| β-strand | 216-225 | 10 | 31 |
| β-strand | 228-237 | 10 | 31 |
| α-helix | 239-243 | 5 | |
| α-helix | 245-275 | 31 | |
| α-helix | 278-281 | 4 | |
| α-helix | 282-293 | 12 | |
| α-helix | 300-310 | 11 | |
| α-helix | 315-318 | 4 | |
| α-helix | 319-323 | 5 | |
| α-helix | 327-347 | 21 | |
| α-helix | 348-352 | 5 | |
| α-helix | 353-370 | 18 | |
| α-helix | 373-376 | 4 | |
| α-helix | 377-379 | 3 | |
| α-helix | 383-428 | 46 | |
| α-helix | 442-455 | 14 | |
| α-helix | 476-479 | 4 | |
| β-strand | 485 | 1 | 32 |
| α-helix | 496-503 | 8 | |
| α-helix | 514-515 | 2 | |
| β-strand | 520 | 1 | 32 |
| α-helix | 522-547 | 26 | |
| β-strand | 549-559 | 11 | 31 |
| β-strand | 574-578 | 5 | 33 |
| β-strand | 583-592 | 10 | 33 |
| β-strand | 595-604 | 10 | 33 |
| β-strand | 615-623 | 9 | 33 |
| β-strand | 636-645 | 10 | 34 |
| β-strand | 648-655 | 8 | 34 |
| β-strand | 664-665 | 2 | 35 |
| β-strand | 668-670 | 3 | 34 |
| α-helix | 671-674 | 4 | |
| α-helix | 701 | 1 | |
| β-strand | 702-707 | 6 | 33 |
| β-strand | 713-714 | 2 | 35 |
| β-strand | 719-725 | 7 | 27 |
| β-strand | 730-735 | 6 | 27 |
| β-strand | 740-745 | 6 | 27 |
| α-helix | 749-750 | 2 | |
| α-helix | 753-754 | 2 | |
Chain J: 33 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-35 | 15 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-63 | 10 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-93 | 9 | |
| α-helix | 100-102 | 3 | |
| α-helix | 103-110 | 8 | |
| α-helix | 111-113 | 3 | |
| α-helix | 114-127 | 14 | |
| α-helix | 131-144 | 14 | |
| α-helix | 150-157 | 8 | |
| α-helix | 164-167 | 4 | |
| α-helix | 452-477 | 26 | |
| α-helix | 481-489 | 9 | |
| α-helix | 493-496 | 4 | |
| α-helix | 499-512 | 14 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-546 | 11 | |
| α-helix | 549-562 | 14 | |
| α-helix | 567-578 | 12 | |
| α-helix | 583-596 | 14 | |
| α-helix | 601-613 | 13 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-647 | 13 | |
| α-helix | 651-664 | 14 | |
| α-helix | 669-681 | 13 | |
| α-helix | 685-698 | 14 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-732 | 14 | |
| α-helix | 737-750 | 14 | |
| α-helix | 753-766 | 14 | |
| α-helix | 773-779 | 7 | |
Chain K: 34 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-15 | 12 | |
| α-helix | 20-32 | 13 | |
| α-helix | 37-49 | 13 | |
| α-helix | 53-61 | 9 | |
| α-helix | 70-82 | 13 | |
| α-helix | 86-94 | 9 | |
| α-helix | 128-142 | 15 | |
| α-helix | 146-159 | 14 | |
| α-helix | 164-170 | 7 | |
| α-helix | 178-187 | 10 | |
| α-helix | 190-192 | 3 | |
| α-helix | 195-209 | 15 | |
| α-helix | 215-217 | 3 | |
| α-helix | 227-229 | 3 | |
| α-helix | 231-243 | 13 | |
| α-helix | 247-260 | 14 | |
| α-helix | 267-277 | 11 | |
| α-helix | 281-294 | 14 | |
| α-helix | 299-312 | 14 | |
| α-helix | 316-329 | 14 | |
| α-helix | 334-346 | 13 | |
| α-helix | 350-363 | 14 | |
| α-helix | 368-380 | 13 | |
| α-helix | 384-397 | 14 | |
| α-helix | 402-415 | 14 | |
| α-helix | 418-434 | 17 | |
| α-helix | 441-444 | 4 | |
| α-helix | 445-457 | 13 | |
| α-helix | 461-474 | 14 | |
| α-helix | 479-491 | 13 | |
| α-helix | 497-508 | 12 | |
| α-helix | 513-527 | 15 | |
| β-strand | 551 | 1 | 18 |
| α-helix | 555-559 | 5 | |
| α-helix | 561-564 | 4 | |
13 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 10 | L | protein | 185 | Homo sapiens | Q9UM13 (AlphaFold model) |
| Anaphase-promoting complex subunit 15 | D | protein | 121 | Homo sapiens | P60006 (AlphaFold model) |
| Anaphase-promoting complex subunit 1 | A | protein | 1944 | Homo sapiens | Q9H1A4 (AlphaFold model) |
| Anaphase-promoting complex subunit 2 | N | protein | 822 | Homo sapiens | Q9UJX6 (AlphaFold model) |
| Anaphase-promoting complex subunit 4 | I | protein | 814 | Homo sapiens | Q9UJX5 |
| Anaphase-promoting complex subunit 5 | O | protein | 755 | Homo sapiens | Q9UJX4 |
| F-box only protein 5 | S | protein | 447 | Homo sapiens | Q9UKT4 |
| Cell division cycle protein 16 homolog | K, Q | protein | 620 | Homo sapiens | Q13042 |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | Homo sapiens | Q8NHZ8 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | Homo sapiens | Q9BS18 |
| Anaphase-promoting complex subunit 16 | H | protein | 110 | Homo sapiens | Q96DE5 |
| Cell division cycle protein 27 homolog | J, P | protein | 824 | Homo sapiens | P30260 |
4 more molecules are not listed.
Sequence of entity 1 (L), FASTA
>9GAW_1 Anaphase-promoting complex subunit 10 (chains L)
MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 2 (D), FASTA
>9GAW_2 Anaphase-promoting complex subunit 15 (chains D)
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASE
HYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWM
I
Sequence of entity 3 (A), FASTA
>9GAW_3 Anaphase-promoting complex subunit 1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGTPQNVATSSS
LTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGV
HSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI
REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA
PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSTPKP
LSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELS
NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF
VTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVE
SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG
EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE
PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT
IAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIY
HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN
HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMAL
PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG
VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG
HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV
YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN
VPEQLYQYMVGGHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNN
RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS
LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS
APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM
ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV
PVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL
SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA
FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL
GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL
QVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ
LKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 4 (N), FASTA
>9GAW_4 Anaphase-promoting complex subunit 2 (chains N)
MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF
HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW
VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIR
NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
VVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS
Sequence of entity 5 (I), FASTA
>9GAW_5 Anaphase-promoting complex subunit 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESE
AENQQAGAAALAPEIVIKVEKLDPELDSENLYFQ
Sequence of entity 6 (O), FASTA
>9GAW_6 Anaphase-promoting complex subunit 5 (chains O)
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRL
NQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFS
GTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR
DEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKEL
NNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSL
RYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVL
LEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDI
SIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQ
GCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNS
IEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIA
LPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDK
GRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARL
YHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL
Sequence of entity 7 (S), FASTA
>9GAW_7 F-box only protein 5 (chains S)
MSRRPCSCALRPPRCSCSASPSAVTAAGRPRPSDSCKEESSTLSVKMKCDFNCNHVHSGL
KLVKPDDIGRLVSYTPAYLEGSCKDCIKDYERLSCIGSPIVSPRIVQLETESKRLHNKEN
QHVQQTLNSTNEIEALETSRLYEDSGYSSFSLQSGLSEHEEGSLLEENFGDSLQSCLLQI
QSPDQYPNKNLLPVLHFEKVVCSTLKKNAKRNPKVDREMLKEIIARGNFRLQNIIGRKMG
LECVDILSELFRRGLRHVLATILAQLSDMDLINVSKVSTTWKKILEDDKGAFQLYSKAIQ
RVTENNNKFSPHASTREYVMFRTPLASVQKSAAQTSLKKDAQTKLSNQGDQKGSTYSRHN
EFSEVAKTLKKNESLKACIRCNSPAKYDCYLQRATCKREGCGFDYCTKCLCNYHTTKDCS
DGKLLKASCKIGPLPGTKKSKKNLRRL
Sequence of entity 8 (K, Q), FASTA
>9GAW_8 Cell division cycle protein 16 homolog (chains K, Q)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 9 (G, W), FASTA
>9GAW_9 Anaphase-promoting complex subunit CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQM
INDRIGYKPQPKPNNRSSQFGSLEF
Sequence of entity 10 (M), FASTA
>9GAW_10 Anaphase-promoting complex subunit 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Sequence of entity 11 (H), FASTA
>9GAW_11 Anaphase-promoting complex subunit 16 (chains H)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 12 (J, P), FASTA
>9GAW_12 Cell division cycle protein 27 homolog (chains J, P)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 6 |
Primary citation
Cryo-EM structures of apo-APC/C and APC/C CDH1:EMI1 complexes provide insights into APC/C regulation. Hofler, A., Yu, J., Yang, J. et al. Nat Commun (2024) 15:10074-10074. DOI 10.1038/s41467-024-54398-5 · PubMed
Other PDB entries of the same protein (UniProt Q9UM13 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1JHJ 1.6 Å, Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
- 8PKP 3.2 Å, Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2…
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 8TAU 3.5 Å, APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
- 9N9R 3.9 Å, Model of APC/C-CDC20-UBE2C from H2A/H2B-bound complex
Browse structure collections
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