8PKP: Apo Anaphase-promoting complex/cyclosome
Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution. Determined by electron microscopy at 3.2 Å resolution. Released 19 Jul 2023.
- Method
- Electron microscopy
- Resolution
- 3.2 Å
- Organism
- Homo sapiens
- Chains
- 19
- Atoms
- 63,749
- Mol. weight
- 1166.03 kDa
- Ligands
- ZN
- Released
- 19 Jul 2023
Explore 8PKP in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8PKP contains 458 α-helices and 126 β-strands across 19 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 81 helices, 54 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-13 | 3 | 1 |
| β-strand | 18-19 | 2 | 2 |
| α-helix | 23-28 | 6 | |
| β-strand | 72-78 | 7 | 3 |
| β-strand | 90-96 | 7 | 3 |
| β-strand | 99-103 | 5 | 3 |
| β-strand | 113-118 | 6 | 3 |
| β-strand | 125-132 | 8 | 4 |
| α-helix | 144-146 | 3 | |
| β-strand | 147-154 | 8 | 4 |
| β-strand | 158-163 | 6 | 4 |
| β-strand | 168-172 | 5 | 4 |
| β-strand | 177-182 | 6 | 5 |
| β-strand | 187-191 | 5 | 5 |
| β-strand | 210-213 | 4 | 5 |
| α-helix | 219-220 | 2 | |
| β-strand | 221-222 | 2 | 5 |
| β-strand | 224-226 | 3 | 6 |
| β-strand | 237-238 | 2 | 6 |
| β-strand | 244-249 | 6 | 6 |
| β-strand | 255-260 | 6 | 6 |
| β-strand | 265-273 | 9 | 6 |
| α-helix | 346-351 | 6 | |
| α-helix | 354-355 | 2 | |
| β-strand | 407-414 | 8 | 6 |
| α-helix | 415-417 | 3 | |
| β-strand | 427-434 | 8 | 7 |
| β-strand | 440-446 | 7 | 7 |
| β-strand | 451-459 | 9 | 7 |
| β-strand | 466-475 | 10 | 7 |
| β-strand | 478-482 | 5 | 1 |
| β-strand | 487-491 | 5 | 1 |
| β-strand | 497-501 | 5 | 1 |
| β-strand | 504-510 | 7 | 1 |
| β-strand | 584-588 | 5 | 2 |
| β-strand | 594-599 | 6 | 2 |
| β-strand | 604-608 | 5 | 2 |
| α-helix | 609-611 | 3 | |
| α-helix | 616-628 | 13 | |
| α-helix | 631-646 | 16 | |
| α-helix | 656-668 | 13 | |
| α-helix | 705-712 | 8 | |
| α-helix | 714-721 | 8 | |
| β-strand | 748 | 1 | 8 |
| α-helix | 756-758 | 3 | |
| α-helix | 759-774 | 16 | |
| α-helix | 781-796 | 16 | |
| α-helix | 800-809 | 10 | |
| α-helix | 820-821 | 2 | |
| β-strand | 822 | 1 | 8 |
| α-helix | 844-851 | 8 | |
| α-helix | 858-859 | 2 | |
| β-strand | 860-862 | 3 | 9 |
| α-helix | 868-877 | 10 | |
| α-helix | 878-882 | 5 | |
| β-strand | 896-898 | 3 | 9 |
| α-helix | 926-937 | 12 | |
| α-helix | 941-944 | 4 | |
| α-helix | 949-964 | 16 | |
| α-helix | 972-978 | 7 | |
| α-helix | 981-991 | 11 | |
| α-helix | 1021-1027 | 7 | |
| β-strand | 1031 | 1 | 10 |
| α-helix | 1033-1041 | 9 | |
| α-helix | 1046 | 1 | |
| β-strand | 1047-1048 | 2 | 11 |
| α-helix | 1059-1087 | 29 | |
| α-helix | 1101-1104 | 4 | |
| β-strand | 1109-1111 | 3 | 11 |
| β-strand | 1116-1118 | 3 | 11 |
| α-helix | 1133-1145 | 13 | |
| α-helix | 1155-1157 | 3 | |
| α-helix | 1166-1168 | 3 | |
| α-helix | 1169-1182 | 14 | |
| α-helix | 1185-1187 | 3 | |
| α-helix | 1193-1197 | 5 | |
| α-helix | 1202-1214 | 13 | |
| α-helix | 1222-1229 | 8 | |
| α-helix | 1237-1238 | 2 | |
| α-helix | 1247-1260 | 14 | |
| α-helix | 1267-1277 | 11 | |
| α-helix | 1291-1306 | 16 | |
| α-helix | 1321-1330 | 10 | |
| β-strand | 1352-1353 | 2 | 12 |
| α-helix | 1360-1374 | 15 | |
| α-helix | 1381-1385 | 5 | |
| α-helix | 1389-1390 | 2 | |
| α-helix | 1395-1397 | 3 | |
| α-helix | 1401-1414 | 14 | |
| α-helix | 1416-1418 | 3 | |
| α-helix | 1423-1428 | 6 | |
| α-helix | 1432-1435 | 4 | |
| α-helix | 1454-1475 | 22 | |
| β-strand | 1481 | 1 | 13 |
| α-helix | 1482-1499 | 18 | |
| α-helix | 1504-1507 | 4 | |
| α-helix | 1509-1526 | 18 | |
| α-helix | 1533-1543 | 11 | |
| α-helix | 1552-1565 | 14 | |
| α-helix | 1567-1570 | 4 | |
| β-strand | 1572-1574 | 3 | 14 |
| α-helix | 1578-1587 | 10 | |
| α-helix | 1604-1612 | 9 | |
| β-strand | 1614-1616 | 3 | 14 |
| β-strand | 1618 | 1 | 15 |
| β-strand | 1620-1623 | 4 | 16 |
| β-strand | 1629 | 1 | 16 |
| β-strand | 1633-1638 | 6 | 17 |
| α-helix | 1639-1640 | 2 | |
| β-strand | 1647-1652 | 6 | 17 |
| β-strand | 1656 | 1 | 15 |
| α-helix | 1657-1659 | 3 | |
| α-helix | 1660-1662 | 3 | |
| β-strand | 1663-1669 | 7 | 17 |
| β-strand | 1673 | 1 | 18 |
| β-strand | 1676-1679 | 4 | 17 |
| α-helix | 1685-1692 | 8 | |
| β-strand | 1696-1699 | 4 | 16 |
| β-strand | 1701 | 1 | 18 |
| α-helix | 1726-1731 | 6 | |
| α-helix | 1745-1750 | 6 | |
| α-helix | 1751-1755 | 5 | |
| α-helix | 1765-1780 | 16 | |
| α-helix | 1784-1786 | 3 | |
| α-helix | 1787-1801 | 15 | |
| α-helix | 1811-1820 | 10 | |
| α-helix | 1824-1826 | 3 | |
| α-helix | 1844-1859 | 16 | |
| α-helix | 1860-1864 | 5 | |
| α-helix | 1865-1873 | 9 | |
| α-helix | 1879-1881 | 3 | |
| α-helix | 1882-1892 | 11 | |
| α-helix | 1894-1896 | 3 | |
| α-helix | 1911-1919 | 9 | |
| α-helix | 1925-1935 | 11 | |
Chain C: 4 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-10 | 8 | 32 |
| β-strand | 11-12 | 2 | 35 |
| β-strand | 13-14 | 2 | 33 |
| β-strand | 15 | 1 | 34 |
| β-strand | 22 | 1 | 37 |
| β-strand | 29 | 1 | 37 |
| α-helix | 41-43 | 3 | |
| β-strand | 46-48 | 3 | 38 |
| β-strand | 49 | 1 | 39 |
| β-strand | 54-56 | 3 | 38 |
| α-helix | 57-67 | 11 | |
| β-strand | 72 | 1 | 40 |
| α-helix | 78 | 1 | |
| β-strand | 79 | 1 | 40 |
| α-helix | 80 | 1 | |
| β-strand | 82 | 1 | 39 |
Chain D: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-11 | 3 | |
| α-helix | 22-26 | 5 | |
| α-helix | 27-45 | 19 | |
Chain G: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-10 | 7 | |
| α-helix | 13-15 | 3 | |
| α-helix | 17-23 | 7 | |
Chain H: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 52-91 | 40 | |
| α-helix | 93-95 | 3 | |
| α-helix | 99-102 | 4 | |
Chain I: 23 helices, 34 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 12-15 | 4 | 22 |
| β-strand | 18 | 1 | 23 |
| β-strand | 23-28 | 6 | 24 |
| β-strand | 34-39 | 6 | 24 |
| β-strand | 44-48 | 5 | 24 |
| α-helix | 50-52 | 3 | |
| β-strand | 54-57 | 4 | 24 |
| β-strand | 68-73 | 6 | 25 |
| β-strand | 79-84 | 6 | 25 |
| β-strand | 89-94 | 6 | 25 |
| β-strand | 100-105 | 6 | 25 |
| β-strand | 110-117 | 8 | 26 |
| α-helix | 123-138 | 16 | |
| α-helix | 140-141 | 2 | |
| α-helix | 143-146 | 4 | |
| α-helix | 163-168 | 6 | |
| β-strand | 174-180 | 7 | 26 |
| β-strand | 185-189 | 5 | 26 |
| β-strand | 193-198 | 6 | 26 |
| β-strand | 204-210 | 7 | 27 |
| β-strand | 216-225 | 10 | 27 |
| β-strand | 228-237 | 10 | 27 |
| α-helix | 239-243 | 5 | |
| α-helix | 245-293 | 49 | |
| α-helix | 300-309 | 10 | |
| α-helix | 315-319 | 5 | |
| α-helix | 320-324 | 5 | |
| α-helix | 327-346 | 20 | |
| α-helix | 347-352 | 6 | |
| α-helix | 353-370 | 18 | |
| α-helix | 373-376 | 4 | |
| α-helix | 377-379 | 3 | |
| α-helix | 383-428 | 46 | |
| α-helix | 442-455 | 14 | |
| α-helix | 475-477 | 3 | |
| α-helix | 496-503 | 8 | |
| α-helix | 514-515 | 2 | |
| α-helix | 522-545 | 24 | |
| β-strand | 549-559 | 11 | 27 |
| β-strand | 574-577 | 4 | 28 |
| β-strand | 583 | 1 | 29 |
| β-strand | 584-592 | 9 | 28 |
| β-strand | 595-601 | 7 | 28 |
| β-strand | 604 | 1 | 29 |
| β-strand | 615-623 | 9 | 28 |
| β-strand | 632 | 1 | 28 |
| β-strand | 636-642 | 7 | 30 |
| β-strand | 648-655 | 8 | 30 |
| β-strand | 664-670 | 7 | 30 |
| α-helix | 671-674 | 4 | |
| β-strand | 702-707 | 6 | 28 |
| β-strand | 711-713 | 3 | 30 |
| β-strand | 719-724 | 6 | 22 |
| β-strand | 730-735 | 6 | 22 |
| β-strand | 740 | 1 | 23 |
| β-strand | 741-745 | 5 | 22 |
| α-helix | 753-754 | 2 | |
Chain J: 33 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-17 | 11 | |
| α-helix | 21-34 | 14 | |
| α-helix | 38-50 | 13 | |
| α-helix | 54-63 | 10 | |
| α-helix | 69-81 | 13 | |
| α-helix | 85-93 | 9 | |
| α-helix | 99-101 | 3 | |
| α-helix | 103-110 | 8 | |
| α-helix | 111-113 | 3 | |
| α-helix | 114-127 | 14 | |
| α-helix | 131-144 | 14 | |
| α-helix | 150-157 | 8 | |
| α-helix | 164-167 | 4 | |
| α-helix | 452-477 | 26 | |
| α-helix | 481-489 | 9 | |
| α-helix | 493-496 | 4 | |
| α-helix | 499-511 | 13 | |
| α-helix | 515-528 | 14 | |
| α-helix | 536-545 | 10 | |
| α-helix | 550-562 | 13 | |
| α-helix | 567-578 | 12 | |
| α-helix | 583-596 | 14 | |
| α-helix | 601-614 | 14 | |
| α-helix | 617-630 | 14 | |
| α-helix | 635-646 | 12 | |
| α-helix | 651-664 | 14 | |
| α-helix | 670-681 | 12 | |
| α-helix | 692-698 | 7 | |
| α-helix | 699-701 | 3 | |
| α-helix | 703-715 | 13 | |
| α-helix | 719-732 | 14 | |
| α-helix | 737-749 | 13 | |
| α-helix | 754-766 | 13 | |
Chain K: 33 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-15 | 13 | |
| α-helix | 20-32 | 13 | |
| α-helix | 37-49 | 13 | |
| α-helix | 53-61 | 9 | |
| α-helix | 62-64 | 3 | |
| α-helix | 65-68 | 4 | |
| α-helix | 70-82 | 13 | |
| α-helix | 86-93 | 8 | |
| α-helix | 128-142 | 15 | |
| α-helix | 147-159 | 13 | |
| α-helix | 164-170 | 7 | |
| α-helix | 178-187 | 10 | |
| α-helix | 195-209 | 15 | |
| α-helix | 226-228 | 3 | |
| α-helix | 231-242 | 12 | |
| α-helix | 247-260 | 14 | |
| α-helix | 268-277 | 10 | |
| α-helix | 281-294 | 14 | |
| α-helix | 299-312 | 14 | |
| α-helix | 316-329 | 14 | |
| α-helix | 334-345 | 12 | |
| α-helix | 350-363 | 14 | |
| α-helix | 368-379 | 12 | |
| α-helix | 385-397 | 13 | |
| α-helix | 402-415 | 14 | |
| α-helix | 419-434 | 16 | |
| α-helix | 441-444 | 4 | |
| α-helix | 445-457 | 13 | |
| α-helix | 461-474 | 14 | |
| α-helix | 479-491 | 13 | |
| α-helix | 495-508 | 14 | |
| α-helix | 513-527 | 15 | |
| β-strand | 551 | 1 | 13 |
| α-helix | 555-558 | 4 | |
11 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 1 | A | protein | 1944 | Homo sapiens | Q9H1A4 (AlphaFold model) |
| Anaphase-promoting complex subunit 15 | D | protein | 121 | Homo sapiens | P60006 (AlphaFold model) |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | Homo sapiens | Q8NHZ8 (AlphaFold model) |
| Anaphase-promoting complex subunit 16 | H | protein | 110 | Homo sapiens | Q96DE5 (AlphaFold model) |
| Cell division cycle protein 27 homolog | J, P | protein | 824 | Homo sapiens | P30260 |
| Cell division cycle protein 16 homolog | K, Q | protein | 620 | Homo sapiens | Q13042 |
| Anaphase-promoting complex subunit 10 | L | protein | 185 | Homo sapiens | Q9UM13 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | Homo sapiens | Q9BS18 |
| Anaphase-promoting complex subunit 5 | O | protein | 755 | Homo sapiens | Q9UJX4 |
| Cell division cycle protein 23 homolog | U, V | protein | 597 | Homo sapiens | Q9UJX2 |
| Anaphase-promoting complex subunit 7 | Y, Z | protein | 565 | Homo sapiens | Q9UJX3 |
| Anaphase-promoting complex subunit 4 | I | protein | 814 | Homo sapiens | Q9UJX5 |
2 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>8PKP_1 Anaphase-promoting complex subunit 1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGTPQNVATSSS
LTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGV
HSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI
REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA
PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSTPKP
LSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELS
NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF
VTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVE
SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG
EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE
PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT
IAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIY
HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN
HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMAL
PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG
VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG
HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV
YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN
VPEQLYQYMVGGHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNN
RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS
LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS
APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM
ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV
PVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL
SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA
FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL
GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL
QVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ
LKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 2 (D), FASTA
>8PKP_2 Anaphase-promoting complex subunit 15 (chains D)
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASE
HYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWM
I
Sequence of entity 3 (G, W), FASTA
>8PKP_3 Anaphase-promoting complex subunit CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLSSDPKSREQM
INDRIGYKPQPKPNNRSSQFGSLEF
Sequence of entity 4 (H), FASTA
>8PKP_4 Anaphase-promoting complex subunit 16 (chains H)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 5 (J, P), FASTA
>8PKP_5 Cell division cycle protein 27 homolog (chains J, P)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVI
SPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sequence of entity 6 (K, Q), FASTA
>8PKP_6 Cell division cycle protein 16 homolog (chains K, Q)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 7 (L), FASTA
>8PKP_7 Anaphase-promoting complex subunit 10 (chains L)
MTTPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 8 (M), FASTA
>8PKP_8 Anaphase-promoting complex subunit 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Sequence of entity 9 (O), FASTA
>8PKP_9 Anaphase-promoting complex subunit 5 (chains O)
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRL
NQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFS
GTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSR
DEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKEL
NNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSL
RYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVL
LEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDI
SIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQ
GCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNS
IEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIA
LPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDK
GRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARL
YHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL
Sequence of entity 10 (U, V), FASTA
>8PKP_10 Cell division cycle protein 23 homolog (chains U, V)
MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAF
SLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMY
SRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLR
KLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTE
LQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM
DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKL
NPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLY
YYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQL
TESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFN
DTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP
Sequence of entity 11 (Y, Z), FASTA
>8PKP_11 Anaphase-promoting complex subunit 7 (chains Y, Z)
MNVIDHVRDMAAAGLHSNVRLLSSLLLTMSNNNPELFSPPQKYQLLVYHADSLFHDKEYR
NAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPSEIEVKYKMAECYTMLKQDKD
AIAILDGIPSRQRTPKINMMLANLYKKAGQERPSVTSYKEVLRQCPLALDAILGLLSLSV
KGAEVASMTMNVIQTVPNLDWLSVWIKAYAFVHTGDNSRAISTICSLEKKSLLRDNVDLL
GSLADLYFRAGDNKNSVLKFEQAQMLDPYLIKGMDVYGYLLAREGRLEDVENLGCRLFNI
SDQHAEPWVVSGCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAII
HFREAIRLAPCRLDCYEGLIECYLASNSIREAMVMANNVYKTLGANAQTLTLLATVCLED
PVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRI
LGDFLVAVNEYQEAMDQYSIALSLDPNDQKSLEGMQKMEKEESPTDATQEEDVDDMEGSG
EEGDLEGSDSEAAQWADQEQWFGMQ
Sequence of entity 12 (I), FASTA
>8PKP_12 Anaphase-promoting complex subunit 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLSESE
AENQQAGAAALAPEIVIKVEKLDPELDSENLYFQ
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 4 |
Primary citation
Cryo-EM structures of apo-APC/C and APC/C CDH1:EMI1 complexes provide insights into APC/C regulation. Hofler, A., Yu, J., Yang, J. et al. Nat Commun (2024) 15:10074-10074. DOI 10.1038/s41467-024-54398-5 · PubMed
Other PDB entries of the same protein (UniProt Q9H1A4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LGG 2.15 Å, The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1)
- 9GAW 2.9 Å, High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to…
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 8TAU 3.5 Å, APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
- 9N9R 3.9 Å, Model of APC/C-CDC20-UBE2C from H2A/H2B-bound complex
Browse structure collections
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