5KHU: Anaphase-promoting complex subunit 1
Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution. Determined by electron microscopy at 4.8 Å resolution. Released 7 Sept 2016.
- Method
- Electron microscopy
- Resolution
- 4.8 Å
- Organism
- Homo sapiens
- Chains
- 23
- Atoms
- 8,453
- Mol. weight
- 1408.43 kDa
- Released
- 7 Sept 2016
Explore 5KHU in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5KHU contains 287 α-helices and 154 β-strands across 22 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 42 helices, 41 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 18-19 | 2 | 1 |
| α-helix | 23-28 | 6 | |
| β-strand | 73-78 | 6 | 2 |
| β-strand | 90-95 | 6 | 3 |
| β-strand | 99-103 | 5 | 4 |
| β-strand | 113-118 | 6 | 5 |
| β-strand | 127-132 | 6 | 6 |
| β-strand | 147-154 | 8 | 7 |
| β-strand | 158-162 | 5 | 8 |
| β-strand | 168-172 | 5 | 9 |
| β-strand | 177-180 | 4 | 10 |
| β-strand | 189-191 | 3 | 11 |
| β-strand | 210-212 | 3 | 12 |
| β-strand | 221-222 | 2 | 13 |
| β-strand | 224-225 | 2 | 14 |
| β-strand | 237-238 | 2 | 15 |
| β-strand | 245-250 | 6 | 16 |
| β-strand | 255-259 | 5 | 17 |
| β-strand | 266-269 | 4 | 18 |
| β-strand | 271-272 | 2 | 19 |
| β-strand | 408-409 | 2 | 20 |
| β-strand | 432-434 | 3 | 21 |
| β-strand | 440-445 | 6 | 22 |
| β-strand | 452-454 | 3 | 23 |
| β-strand | 458-459 | 2 | 24 |
| β-strand | 466-467 | 2 | 25 |
| β-strand | 488-492 | 5 | 26 |
| β-strand | 496-500 | 5 | 27 |
| β-strand | 505-508 | 4 | 28 |
| β-strand | 586-591 | 6 | 29 |
| β-strand | 594-598 | 5 | 30 |
| β-strand | 604-608 | 5 | 31 |
| α-helix | 615-629 | 15 | |
| α-helix | 631-646 | 16 | |
| α-helix | 655-669 | 15 | |
| α-helix | 758-775 | 18 | |
| α-helix | 781-790 | 10 | |
| α-helix | 800-810 | 11 | |
| α-helix | 843-854 | 12 | |
| α-helix | 867-937 | 71 | |
| α-helix | 940-945 | 6 | |
| α-helix | 948-965 | 18 | |
| α-helix | 971-978 | 8 | |
| α-helix | 1020-1028 | 9 | |
| α-helix | 1032-1042 | 11 | |
| α-helix | 1058-1088 | 31 | |
| β-strand | 1108-1111 | 4 | 32 |
| β-strand | 1116-1119 | 4 | 33 |
| α-helix | 1132-1146 | 15 | |
| α-helix | 1154-1161 | 8 | |
| α-helix | 1168-1193 | 26 | |
| α-helix | 1201-1217 | 17 | |
| α-helix | 1221-1228 | 8 | |
| α-helix | 1246-1261 | 16 | |
| α-helix | 1266-1278 | 13 | |
| α-helix | 1290-1307 | 18 | |
| α-helix | 1320-1331 | 12 | |
| α-helix | 1359-1375 | 17 | |
| α-helix | 1380-1387 | 8 | |
| α-helix | 1392-1415 | 24 | |
| α-helix | 1422-1429 | 8 | |
| α-helix | 1431-1437 | 7 | |
| α-helix | 1453-1476 | 24 | |
| α-helix | 1481-1500 | 20 | |
| α-helix | 1503-1527 | 25 | |
| α-helix | 1532-1546 | 15 | |
| α-helix | 1551-1570 | 20 | |
| β-strand | 1572-1574 | 3 | 34 |
| α-helix | 1578-1588 | 11 | |
| α-helix | 1603-1613 | 11 | |
| β-strand | 1614-1616 | 3 | 35 |
| β-strand | 1620-1622 | 3 | 36 |
| β-strand | 1635-1638 | 4 | 37 |
| β-strand | 1648-1649 | 2 | 38 |
| β-strand | 1663-1668 | 6 | 39 |
| β-strand | 1675-1678 | 4 | 40 |
| α-helix | 1684-1693 | 10 | |
| β-strand | 1696-1698 | 3 | 41 |
| α-helix | 1764-1781 | 18 | |
| α-helix | 1785-1803 | 19 | |
| α-helix | 1808-1822 | 15 | |
| α-helix | 1844-1873 | 30 | |
| α-helix | 1878-1893 | 16 | |
Chain B: 0 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-10 | 8 | 42 |
Chain C: 21 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 29-62 | 34 | |
| α-helix | 77-106 | 30 | |
| α-helix | 112-137 | 26 | |
| α-helix | 150-165 | 16 | |
| α-helix | 169-182 | 14 | |
| α-helix | 184-199 | 16 | |
| α-helix | 202-213 | 12 | |
| α-helix | 215-222 | 8 | |
| α-helix | 228-293 | 66 | |
| α-helix | 299-310 | 12 | |
| α-helix | 312-327 | 16 | |
| α-helix | 330-344 | 15 | |
| α-helix | 346-360 | 15 | |
| α-helix | 365-378 | 14 | |
| α-helix | 380-395 | 16 | |
| α-helix | 398-412 | 15 | |
| α-helix | 414-427 | 14 | |
| α-helix | 432-439 | 8 | |
| α-helix | 441-463 | 23 | |
| α-helix | 468-480 | 13 | |
| α-helix | 483-495 | 13 | |
Chain E: 2 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 52-96 | 45 | |
| α-helix | 98-103 | 6 | |
Chain F: 22 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-18 | 13 | |
| α-helix | 20-51 | 32 | |
| α-helix | 53-64 | 12 | |
| α-helix | 68-82 | 15 | |
| α-helix | 84-94 | 11 | |
| α-helix | 103-111 | 9 | |
| α-helix | 113-145 | 33 | |
| α-helix | 148-158 | 11 | |
| α-helix | 480-490 | 11 | |
| α-helix | 498-529 | 32 | |
| α-helix | 535-546 | 12 | |
| α-helix | 548-563 | 16 | |
| α-helix | 566-580 | 15 | |
| α-helix | 582-597 | 16 | |
| α-helix | 600-631 | 32 | |
| α-helix | 634-648 | 15 | |
| α-helix | 650-665 | 16 | |
| α-helix | 668-699 | 32 | |
| α-helix | 702-716 | 15 | |
| α-helix | 718-733 | 16 | |
| α-helix | 736-750 | 15 | |
| α-helix | 752-762 | 11 | |
Chains G and W: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-25 | 14 | |
Chain H: 23 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-18 | 13 | |
| α-helix | 20-51 | 32 | |
| α-helix | 53-64 | 12 | |
| α-helix | 68-82 | 15 | |
| α-helix | 84-94 | 11 | |
| α-helix | 103-111 | 9 | |
| α-helix | 113-145 | 33 | |
| α-helix | 148-158 | 11 | |
| α-helix | 164-169 | 6 | |
| α-helix | 480-490 | 11 | |
| α-helix | 498-529 | 32 | |
| α-helix | 535-546 | 12 | |
| α-helix | 548-563 | 16 | |
| α-helix | 566-580 | 15 | |
| α-helix | 582-597 | 16 | |
| α-helix | 600-631 | 32 | |
| α-helix | 634-648 | 15 | |
| α-helix | 650-665 | 16 | |
| α-helix | 668-699 | 32 | |
| α-helix | 702-716 | 15 | |
| α-helix | 718-733 | 16 | |
| α-helix | 736-750 | 15 | |
| α-helix | 752-766 | 15 | |
Chain I: 12 helices, 31 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 23-28 | 6 | 43 |
| β-strand | 35-39 | 5 | 44 |
| β-strand | 44-47 | 4 | 45 |
| α-helix | 49-52 | 4 | |
| β-strand | 54-58 | 5 | 46 |
| β-strand | 68-73 | 6 | 47 |
| β-strand | 79-84 | 6 | 48 |
| β-strand | 90-94 | 5 | 49 |
| β-strand | 103-104 | 2 | 50 |
| β-strand | 112-117 | 6 | 51 |
| α-helix | 132-137 | 6 | |
| α-helix | 163-170 | 8 | |
| β-strand | 174-179 | 6 | 52 |
| β-strand | 184-189 | 6 | 53 |
| α-helix | 190-192 | 3 | |
| β-strand | 193-199 | 7 | 54 |
| β-strand | 204-210 | 7 | 55 |
| β-strand | 216-222 | 7 | 56 |
| β-strand | 229-230 | 2 | 57 |
| β-strand | 233-237 | 5 | 58 |
| α-helix | 238-244 | 7 | |
| α-helix | 315-377 | 63 | |
| α-helix | 382-429 | 48 | |
| α-helix | 441-456 | 16 | |
| α-helix | 495-503 | 9 | |
| α-helix | 521-548 | 28 | |
| β-strand | 551-554 | 4 | 59 |
| β-strand | 558-559 | 2 | 60 |
| β-strand | 574-578 | 5 | 61 |
| β-strand | 583-591 | 9 | 62 |
| β-strand | 596-604 | 9 | 63 |
| β-strand | 615-624 | 10 | 64 |
| β-strand | 631-632 | 2 | 65 |
| β-strand | 636-645 | 10 | 66 |
| β-strand | 648-655 | 8 | 67 |
| β-strand | 664-670 | 7 | 68 |
| α-helix | 672-674 | 3 | |
| α-helix | 679-683 | 5 | |
| β-strand | 702-707 | 6 | 69 |
| β-strand | 711-713 | 3 | 70 |
| β-strand | 719-724 | 6 | 71 |
| β-strand | 730-735 | 6 | 72 |
| β-strand | 741-745 | 5 | 73 |
13 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Anaphase-promoting complex subunit 1 | A | protein | 1944 | Homo sapiens | Q9H1A4 (AlphaFold model) |
| Anaphase-promoting complex subunit 11 | B | protein | 84 | Homo sapiens | Q9NYG5 (AlphaFold model) |
| Cell division cycle protein 23 homolog | C, P | protein | 597 | Homo sapiens | Q9UJX2 (AlphaFold model) |
| Anaphase-promoting complex subunit 16 | E | protein | 110 | Homo sapiens | Q96DE5 (AlphaFold model) |
| Cell division cycle protein 27 homolog | F, H | protein | 824 | Homo sapiens | P30260 |
| Anaphase-promoting complex subunit CDC26 | G, W | protein | 85 | Homo sapiens | Q8NHZ8 |
| Anaphase-promoting complex subunit 4 | I | protein | 808 | Homo sapiens | Q9UJX5 |
| Cell division cycle protein 16 homolog | J, K | protein | 620 | Homo sapiens | Q13042 |
| Anaphase-promoting complex subunit 10 | L | protein | 185 | Homo sapiens | Q9UM13 |
| Anaphase-promoting complex subunit 13 | M | protein | 74 | Homo sapiens | Q9BS18 |
| Anaphase-promoting complex subunit 2 | N | protein | 822 | Homo sapiens | Q9UJX6 |
| Anaphase-promoting complex subunit 5 | O | protein | 755 | Homo sapiens | Q9UJX4 |
5 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>5KHU_1 Anaphase-promoting complex subunit 1 (chains A)
MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS
LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD
SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV
WPTKYGLLFERSASSHEVPPGEPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV
DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFEEQGGEPQNVATSSS
LTAHLRSLSKGDEPVEEPFQNYSSIHSQSRSTSEPSLHSREPEISNMAALSRAHEPALGV
HEFSGVQRFNIESHNQEPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI
REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA
PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSEPKP
LSKLLGELDEVVLLEPVPELRDSSKLHDELYNEDCTFQQLGTYIHSIRDPVHNRVTLELS
NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF
VTCLMNMMGYQTDRLAWTRNFDFEGSLEPVIAPKKARPEETGSDDDWEYLLNSDYHQNVE
SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG
EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE
PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT
IAPQKLQVEQEENRFEFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIY
HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN
HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMAL
PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG
VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG
HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV
YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN
VPEQLYQYMVGGHRRFQTGMHREKHKEPSYQIKEGDTINVDVTCPGATLALAMIYLKTNN
RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS
LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS
APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM
ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV
PVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL
SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA
FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL
GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL
QVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ
LKMPVRALLRLAPLLLGNPQPMVM
Sequence of entity 2 (B), FASTA
>5KHU_2 Anaphase-promoting complex subunit 11 (chains B)
MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCI
LKWLHAQQVQQHCPMCRQEWKFKE
Sequence of entity 3 (C, P), FASTA
>5KHU_3 Cell division cycle protein 23 homolog (chains C, P)
MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAF
SLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMY
SRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLR
KLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTE
LQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENM
DTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKL
NPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLY
YYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQL
TESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFN
DEREEGKALLRQILQLRNQGEEPTTEVPAPFFLPASLSANNEPTRRVEPLNLSSVEP
Sequence of entity 4 (E), FASTA
>5KHU_4 Anaphase-promoting complex subunit 16 (chains E)
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFS
YQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
Sequence of entity 5 (F, H), FASTA
>5KHU_5 Cell division cycle protein 27 homolog (chains F, H)
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRL
LKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSL
LGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCL
PNSCTTQVPNHSLSHRQPEEVLTEEPQDTIELNRLNLESENSKYSLNTDSSVSYIDSAVI
EPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALEPLTPSFGILPLETPSPGDGSYLQN
YTNTPPVIDVPSTGAPSKKEVARIGQTGTKSVFSQEGNEREVTPILAQTQSSGPQTSTTP
QVLSPTITSPPNALPRRSSRLFTSDEETTKENEKKLKMKFPPKIPNRKTKSKTNKGGITQ
PNINDELEITKLDSEIISEGKISTIEPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYN
CKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYS
TTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNY
AYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQK
ALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYK
SALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAID
KRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
Sequence of entity 6 (G, W), FASTA
>5KHU_6 Anaphase-promoting complex subunit CDC26 (chains G, W)
MLRRKPTRLELKLDDIEEFENIRKDLETRKKQKEDVEVVGGSDGEGAIGLEEDPKSREQM
INDRIGYKPQPKPNNRSSQFGELEF
Sequence of entity 7 (I), FASTA
>5KHU_7 Anaphase-promoting complex subunit 4 (chains I)
MLRFPTCFPSFRVVGEKQLPQEIIFLVWSPKRDLIALANTAGEVLLHRLASFHRVWSFPP
NENTGKEVTCLAWRPDGKLLAFALADTKKIVLCDVEKPESLHSFSVEAPVSCMHWMEVTV
ESSVLTSFYNAEDESNLLLPKLPTLPKNYSNTSKIFSEENSDEIIKLLGDVRLNILVLGG
SSGFIELYAYGMFKIARVTGIAGTCLALCLSSDLKSLSVVTEVSTNGASEVSYFQLETNL
LYSFLPEVTRMARKFTHISALLQYINLSLTCMCEAWEEILMQMDSRLTKFVQEKNTTTSV
QDEFMHLLLWGKASAELQTLLMNQLTVKGLKKLGQSIESSYSSIQKLVISHLQSGSESLL
YHLSELKGMASWKQKYEPLGLDAAGIEEAITAVGSFILKANELLQVIDSSMKNFKAFFRW
LYVAMLRMTEDHVLPELNKMTQKDITFVAEFLTEHFNEAPDLYNRKGKYFNVERVGQYLK
DEDDDLVSPPNTEGNQWYDFLQNSSHLKESPLLFPYYPRKSLHFVKRRMENIIDQCLQKP
ADVIGKSMNQAICIPLYRDTRSEDSTRRLFKFPFLWNNKTSNLHYLLFTILEDSLYKMCI
LRRHTDISQSVSNGLIAIKFGSFTYATTEKVRRSIYSCLDAQFYDDETVTVVLKDTVGRE
GRDRLLVQLPLSLVYNSEDSAEYQFTGTYSTRLDEQCSAIPTRTMHFEKHWRLLESMKAQ
YVAGNGFRKVSCVLSSNLRHVRVFEMDIDDEWELDESSDEEEEASNKPVKIKEEVLEEEE
AENQQAGAAALAPEIVIKVEKLDPELDS
Sequence of entity 8 (J, K), FASTA
>5KHU_8 Cell division cycle protein 16 homolog (chains J, K)
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHAL
RSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDEEGFKDPSSD
WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQE
EKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAER
HYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPV
SWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTA
AQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKT
AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNAS
TYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKD
KLKCYDFDVHTMKTLKNIIEPPWDFREFEVEKQTAEETGLEPLEEERKTPDSRPSLEETF
EIEMNESDMMLETSMSDHST
Sequence of entity 9 (L), FASTA
>5KHU_9 Anaphase-promoting complex subunit 10 (chains L)
MTEPNKTPPGADPKQLERTGTVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQ
PHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWI
HVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMM
YRSIR
Sequence of entity 10 (M), FASTA
>5KHU_10 Anaphase-promoting complex subunit 13 (chains M)
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDL
ALQYLHENVPPIGN
Sequence of entity 11 (N), FASTA
>5KHU_11 Anaphase-promoting complex subunit 2 (chains N)
MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQEPLCAGCSSDKQQCWCRQALEQF
HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
GKVFLQDGPARPAEPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDEEDDSGEPEDW
VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFEPEREIR
NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
VVTGPALAEIDLQELQGYLQKKVRDQQLVYEAGVYRLPKNCS
Sequence of entity 12 (O), FASTA
>5KHU_12 Anaphase-promoting complex subunit 5 (chains O)
MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRL
NQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFS
GTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELEER
DEGERKMEKEELDVEVREEEVECSGPLSQKQAEFFLSQQAELLKNDETKALEPASLQKEL
NNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSL
RYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVL
LEHEVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDI
SIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQ
GCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNS
IEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIA
LPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDK
GRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARL
YHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL
Primary citation
Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Yamaguchi, M., VanderLinden, R., Weissmann, F. et al. Mol Cell (2016) 63:593-607. DOI 10.1016/j.molcel.2016.07.003 · PubMed
Other PDB entries of the same protein (UniProt Q9H1A4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LGG 2.15 Å, The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1)
- 9GAW 2.9 Å, High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to…
- 6Q6G 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D1 box class
- 6Q6H 3.2 Å, Cryo-EM structure of the APC/C-Cdc20-Cdk2-cyclinA2-Cks2 complex, the D2 box class
- 8PKP 3.2 Å, Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2…
- 5G05 3.4 Å, Cryo-EM structure of combined apo phosphorylated APC
- 8TAU 3.5 Å, APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
- 4UI9 3.6 Å, Atomic structure of the human Anaphase-Promoting Complex
- 6TNT 3.78 Å, SUMOylated apoAPC/C with repositioned APC2 WHB domain
- 6TLJ 3.8 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the…
- 5G04 3.9 Å, Structure of the human APC-Cdc20-Hsl1 complex
- 6TM5 3.9 Å, Cryo-EM structure of the Anaphase-promoting complex/Cyclosome, in complex with the Nek2A…
Browse structure collections
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