5UGG: Protease Inhibitor

Protease Inhibitor. Determined by X-ray diffraction at 1.2 Å resolution. Released 31 May 2017.

Method: X-ray diffraction
Resolution: 1.2 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,389
Mol. weight: 28.11 kDa
Ligands: 89M
Released: 31 May 2017

Explore 5UGG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5UGG contains 10 α-helices and 20 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 20 β-strands

Element	Residues	Length	Sheet
β-strand	563	1	1
β-strand	566-567	2	2
α-helix	568-569	2
β-strand	576-581	6	3
β-strand	586-594	9	3
β-strand	597-600	4	3
α-helix	602-604	3
α-helix	611-613	3
β-strand	614-618	5	3
β-strand	622	1	4
β-strand	631-640	10	3
β-strand	648-652	5	3
α-helix	655-658	4
β-strand	659	1	5
β-strand	662	1	5
α-helix	664-665	2
β-strand	666	1	2
α-helix	667-669	3
α-helix	674-675	2
β-strand	679-684	6	2
β-strand	696	1	4
β-strand	698-705	8	2
α-helix	707-710	4
β-strand	724-727	4	2
β-strand	735	1	1
β-strand	744-749	6	2
β-strand	752-761	10	2
β-strand	772-776	5	2
α-helix	777-780	4
α-helix	781-790	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Plasminogen	A	protein	251	Homo sapiens	P00747 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5UGG_1 Plasminogen (chains A)
EFAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLT
AAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITD
KVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRV
QSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRF
VTWIEGVMRNN

Ligands and cofactors

ID	Name	Formula	Copies
89M	Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)…	C35 H48 N4 O3	1

Primary citation

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors. Law, R.H.P., Wu, G., Leung, E.W.W. et al. Blood Adv (2017) 1:766-771. DOI 10.1182/bloodadvances.2016004150 · PubMed

Other PDB entries of the same protein (UniProt P00747 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6D3Y 1.32 Å, Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin…
5UGD 1.38 Å, Protease Inhibitor
6D40 1.43 Å, Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin…
8F7U 1.47 Å, Macrocyclic Plasmin Inhibitor
7UAH 1.57 Å, Macrocyclic plasmin inhibitor
8F7V 1.65 Å, Macrocyclic plasmin inhibitor
5HPG 1.66 Å, Structure and ligand determinants of the recombinant kringle 5 domain of human plasminogen
1KRN 1.67 Å, Structure of kringle 4 at 4C temperature and 1.67 Å resolution
6OG4 1.7 Å, plasminogen binding group A streptococcal M protein
1KI0 1.75 Å, The X-ray Structure of Human Angiostatin
4CIK 1.78 Å, plasminogen kringle 1 in complex with inhibitor
6D3X 1.8 Å, Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin…

Browse structure collections

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