5W61: BAXP168G monomer co-crystallized with glycerol

Crystal structure of BAXP168G monomer co-crystallized with glycerol. Determined by X-ray diffraction at 2.3 Å resolution. Released 27 Jun 2018.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,279
Mol. weight: 21.31 kDa
Released: 27 Jun 2018

Explore 5W61 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5W61 contains 10 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 0 β-strands

Element	Residues	Length
α-helix	16-34	19
α-helix	54-71	18
α-helix	74-80	7
α-helix	88-100	13
α-helix	107-124	18
α-helix	132-143	12
α-helix	144-148	5
α-helix	149-154	6
α-helix	159-166	8
α-helix	170-187	18

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Apoptosis regulator BAX	A	protein	194	Homo sapiens	Q07812 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5W61_1 Apoptosis regulator BAX (chains A)
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLS
ESLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKL
VLKALSTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTGTWQTVTIFVAGV
LTASLTIWKKMGSS

Primary citation

Ensemble Properties of Bax Determine Its Function. Robin, A.Y., Iyer, S., Birkinshaw, R.W. et al. Structure (2018) 26:1346. DOI 10.1016/j.str.2018.07.006 · PubMed

Other PDB entries of the same protein (UniProt Q07812 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4ZIE 1.8 Å, Crystal Structure of core/latch dimer of Bax in complex with BimBH3
5W60 1.8 Å, Crystal structure of BAXP168G monomer cryo-protected with ethylene glycol
4S0O 1.9 Å, Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (I)
5W5Z 2.0 Å, Crystal structure of BAXP168G in complex with an activating antibody at high resolution
6EB6 2.02 Å, Crystal structure of BAX W139A monomer
8SRX 2.09 Å, Crystal structure of BAK-BAX heterodimer with lysoPC
8G1T 2.09 Å, Crystal structure of Bax core domain BH3-groove dimer - tetrameric fraction P21
6TRR 2.12 Å, Structural insight into tanapoxvirus mediated inhibition of apoptosis
4ZII 2.19 Å, Crystal Structure of core/latch dimer of BaxI66A in complex with BidBH3
4ZIG 2.2 Å, Crystal Structure of core/latch dimer of Bax in complex with BidBH3mini
8SPF 2.2 Å, Crystal structure of Bax core domain BH3-groove dimer - hexameric fraction with…
4BD2 2.21 Å, Bax domain swapped dimer in complex with BidBH3

Browse structure collections

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