5WSU: Myosin VIIa IQ5-SAH

Crystal structure of Myosin VIIa IQ5-SAH in complex with apo-CaM. Determined by X-ray diffraction at 3.0 Å resolution. Released 7 Jun 2017.

Method: X-ray diffraction
Resolution: 3.0 Å
Organisms: Homo sapiens, Mus musculus
Chains: 4
Atoms: 3,104
Mol. weight: 59.93 kDa
Released: 7 Jun 2017

Explore 5WSU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5WSU contains 19 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
α-helix	6-18	13
β-strand	26-28	3	1
α-helix	29-38	10
α-helix	45-54	10
β-strand	62-64	3	1
α-helix	65-74	10
α-helix	82-90	9
β-strand	99-101	3	2
α-helix	102-111	10
α-helix	118-131	14
β-strand	135-137	3	2
α-helix	139-146	8

Chain B: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-18	13
β-strand	27	1	3
α-helix	29-38	10
α-helix	45-53	9
β-strand	63	1	3
α-helix	65-74	10
α-helix	83-92	10
β-strand	99-101	3	4
α-helix	102-111	10
α-helix	118-126	9
β-strand	135-137	3	4
α-helix	139-146	8

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	763-848	86

Chain D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	761-849	89

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin	A, B	protein	152	Homo sapiens	P0DP23 (AlphaFold model)
Unconventional myosin-VIIa	C, D	protein	106	Mus musculus	P97479 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>5WSU_1 Calmodulin (chains A, B)
GPGSADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVD
ADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKL
TDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (C, D), FASTA

>5WSU_2 Unconventional myosin-VIIa (chains C, D)
GPGSRHRLWAVITVQAYARGMIARRLHRRLRVEYQRRLEAERMRLAEEEKLRKEMSAKKA
KEEAERKHQERLAQLAREDAERELKEKEEARRKKELLEQMEKARHE

Primary citation

Ca(2+)-Induced Rigidity Change of the Myosin VIIa IQ Motif-Single alpha Helix Lever Arm Extension. Li, J., Chen, Y., Deng, Y. et al. Structure (2017) 25:579-591.e4. DOI 10.1016/j.str.2017.02.002 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

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