Crystal Structure of AnkB Ankyrin Repeats in Complex with AnkR/AnkB Chimeric Autoinhibition Segment. Determined by X-ray diffraction at 3.3 Å resolution. Released 13 Sept 2017.
Explore 5Y4D in 3D Show helices and sheets RCSB PDB PDBe
5Y4D contains 45 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1602-1613 | 12 | |
| α-helix | 1623-1625 | 3 | |
| α-helix | 1629-1631 | 3 | |
| α-helix | 2029-2041 | 13 | |
| α-helix | 2044-2052 | 9 | |
| α-helix | 2067-2074 | 8 | |
| α-helix | 2077-2086 | 10 | |
| α-helix | 2100-2107 | 8 | |
| α-helix | 2110-2118 | 9 | |
| α-helix | 2133-2139 | 7 | |
| α-helix | 2143-2151 | 9 | |
| α-helix | 2166-2173 | 8 | |
| α-helix | 2176-2184 | 9 | |
| α-helix | 2192-2202 | 11 | |
| α-helix | 2205-2211 | 7 | |
| α-helix | 2225-2227 | 3 | |
| α-helix | 2236-2243 | 8 | |
| α-helix | 2246-2254 | 9 | |
| β-strand | 2263 | 1 | 1 |
| β-strand | 2267 | 1 | 1 |
| α-helix | 2269-2276 | 8 | |
| α-helix | 2279-2287 | 9 | |
| α-helix | 2302-2308 | 7 | |
| α-helix | 2312-2320 | 9 | |
| α-helix | 2335-2341 | 7 | |
| α-helix | 2345-2353 | 9 | |
| α-helix | 2368-2374 | 7 | |
| α-helix | 2378-2386 | 9 | |
| α-helix | 2401-2407 | 7 | |
| α-helix | 2411-2419 | 9 | |
| α-helix | 2434-2440 | 7 | |
| α-helix | 2444-2452 | 9 | |
| α-helix | 2467-2474 | 8 | |
| α-helix | 2477-2485 | 9 | |
| α-helix | 2495-2497 | 3 | |
| α-helix | 2500-2506 | 7 | |
| α-helix | 2510-2518 | 9 | |
| α-helix | 2533-2540 | 8 | |
| α-helix | 2543-2551 | 9 | |
| α-helix | 2566-2573 | 8 | |
| α-helix | 2576-2584 | 9 | |
| α-helix | 2599-2605 | 7 | |
| α-helix | 2609-2618 | 10 | |
| α-helix | 2632-2638 | 7 | |
| α-helix | 2642-2650 | 9 | |
| α-helix | 2665-2672 | 8 | |
| α-helix | 2675-2681 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ankyrin-1,Ankyrin-2,Ankyrin-2 | A | protein | 731 | Mus musculus, Homo sapiens | Q01484 (AlphaFold model), Q02357 (AlphaFold model) |
>5Y4D_1 Ankyrin-1,Ankyrin-2,Ankyrin-2 (chains A) GPGSEFCADQYWNEVAVIDAIPLAATEHDTMLEMSDMQVWSAGDHPPIVSEEDISGSLVP RGSGSKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG APLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLH IASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL DKGANIHMSTK
Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions. Chen, K., Li, J., Wang, C. et al. Elife (2017) 6. DOI 10.7554/eLife.29150 · PubMed
Other PDB entries of the same protein (UniProt Q01484 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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