6CIV: Lactam cyclised mimetic of a fragment of p21

Lactam cyclised mimetic of a fragment of p21. Determined by solution NMR. Released 4 Jul 2018.

Method: Solution NMR
Organism: Homo sapiens
Chains: 1
Atoms: 125
Mol. weight: 1.8 kDa
Released: 4 Jul 2018

Explore 6CIV in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6CIV contains 1 α-helix and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	147-150	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
p21	C	protein	14	Homo sapiens	P38936 (AlphaFold model)

Sequence of entity 1 (C), FASTA

>6CIV_1 p21 (chains C)
GRKRRQASMTEFYH

Primary citation

Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp. Wegener, K.L., McGrath, A.E., Dixon, N.E. et al. Chemistry (2018) 24:11325-11331. DOI 10.1002/chem.201801734 · PubMed

Other PDB entries of the same protein (UniProt P38936 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5E0U 1.93 Å, Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms
2ZVV 2.0 Å, Crystal structure of Proliferating cellular nuclear antigen 1 and Short peptide from…
8GJF 2.0 Å, afupcna bound with peptide mimetic
4RJF 2.01 Å, Crystal structure of the human sliding clamp at 2.0 angstrom resolution
7KQ0 2.4 Å, PCNA bound to peptide mimetic
2ZVW 2.5 Å, Crystal structure of Proliferating cell nuclear antigen 2 and Short peptide from human P21
1AXC 2.6 Å, Human pcna
6CBI 2.75 Å, PCNA in complex with inhibitor
6P8H 3.19 Å, Crystal structure of CDK4 in complex with CyclinD1 and P21
7KQ1 3.3 Å, PCNA bound to truncated peptide mimetic
6CEJ Solution structure of a 14mer fragment of the p21 protein
6CIX Lactam cyclised mimetic of a fragment of p21

Browse structure collections

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