High resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist. Determined by X-ray diffraction at 2.5 Å resolution. Released 21 Nov 2018.
Explore 6FJ3 in 3D Show helices and sheets RCSB PDB PDBe
6FJ3 contains 31 α-helices and 19 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 34-56 | 23 | |
| α-helix | 107 | 1 | |
| β-strand | 108 | 1 | 1 |
| α-helix | 109-110 | 2 | |
| β-strand | 112 | 1 | 2 |
| β-strand | 117 | 1 | 2 |
| β-strand | 121 | 1 | 1 |
| β-strand | 126-130 | 5 | 3 |
| α-helix | 131-132 | 2 | |
| β-strand | 143-147 | 5 | 3 |
| β-strand | 148 | 1 | 4 |
| β-strand | 154 | 1 | 4 |
| α-helix | 155 | 1 | |
| β-strand | 156 | 1 | 5 |
| α-helix | 157 | 1 | |
| β-strand | 163 | 1 | 5 |
| β-strand | 166 | 1 | 3 |
| α-helix | 180-211 | 32 | |
| α-helix | 213-215 | 3 | |
| α-helix | 218-245 | 28 | |
| α-helix | 279-311 | 33 | |
| α-helix | 317-325 | 9 | |
| α-helix | 326-330 | 5 | |
| α-helix | 331-346 | 16 | |
| α-helix | 358-360 | 3 | |
| α-helix | 361-382 | 22 | |
| α-helix | 1226-1228 | 3 | |
| α-helix | 1233-1243 | 11 | |
| β-strand | 1250-1255 | 6 | 6 |
| β-strand | 1258 | 1 | 7 |
| α-helix | 1265-1276 | 12 | |
| α-helix | 1279-1283 | 5 | |
| β-strand | 1284-1289 | 6 | 6 |
| β-strand | 1292 | 1 | 7 |
| α-helix | 1294-1306 | 13 | |
| β-strand | 1310-1313 | 4 | 6 |
| α-helix | 1319-1326 | 8 | |
| β-strand | 1331-1334 | 4 | 6 |
| α-helix | 1343-1350 | 8 | |
| α-helix | 1353 | 1 | |
| β-strand | 1354-1358 | 5 | 6 |
| α-helix | 1361-1366 | 6 | |
| β-strand | 1373-1375 | 3 | 6 |
| α-helix | 1380-1394 | 15 | |
| α-helix | 1399-426 | 44 | |
| α-helix | 435-449 | 15 | |
| α-helix | 451-456 | 6 | |
| α-helix | 457-461 | 5 | |
| α-helix | 464-477 | 14 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 3-33 | 31 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Parathyroid hormone/parathyroid hormone-related peptide receptor,Parathyroid hormone/parathyroid… | A | protein | 602 | Homo sapiens, Pyrococcus abyssi (strain GE5 / Orsay) | Q03431 (AlphaFold model), Q9V2J8 (AlphaFold model) |
| Parathyroid hormone | B | protein | 35 | Equus caballus | Q27IM2 (AlphaFold model) |
>6FJ3_1 Parathyroid hormone/parathyroid hormone-related peptide receptor,Parathyroid hormone/parathyroid hormone-related peptide receptor,GlgA glycogen synthase,Parathyroid hormone/parathyroid hormone-related peptide receptor (chains A) GPALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPAGRPCLPEWDHILCWPLGAPGE VVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFD RLGMICTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVMDAVLY SGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWIAVEGLY LHSLIFKAFFSEKKYLWGFTVFGWGLPAIFVAVWVSVRATLANTGCWDLSSGNNKWIIQV PILASIVLNFILFINIVRVLATKGIDCSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMF IGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHGNVKVIT EMLSREFVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNETGIL VKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSDTRQQYRKLAKSTLVLMPLFG VHYIVFMLTPYTEVSGTLWQVRMHYEMLFNSFQGFFVAIAYCFCNGEVQAEIKKSWSRWT LA
>6FJ3_2 Parathyroid hormone (chains B) XVAEIQLMHQRAKWLNSLERVEWLRKKLQDVHNYX
Water and common crystallization additives (ACY, PG4, CL) are not listed.
High-resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist. Ehrenmann, J., Schoppe, J., Klenk, C. et al. Nat Struct Mol Biol (2018) 25:1086-1092. DOI 10.1038/s41594-018-0151-4 · PubMed
Other PDB entries of the same protein (UniProt Q03431 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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