6N88: Importin7:Importin beta:Histone H1.0 complex

Cryo-EM structure of the Importin7:Importin beta:Histone H1.0 complex. Determined by electron microscopy at 6.2 Å resolution. Released 27 Feb 2019.

Method
Electron microscopy
Resolution
6.2 Å
Organisms
Xenopus laevis, Homo sapiens
Chains
3
Atoms
6,446
Mol. weight
237.74 kDa
Released
27 Feb 2019

Explore 6N88 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6N88 contains 95 α-helices and 4 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 39 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix293-30917
α-helix320-3223
α-helix323-34018
α-helix344-36623
α-helix382-40322
α-helix410-42011
α-helix429-4335
α-helix434-4396
α-helix440-4445
α-helix445-4495
α-helix458-4647
α-helix472-48211
α-helix493-50614
α-helix511-52616
α-helix535-55218
α-helix556-57015
α-helix574-60027
α-helix605-62016
α-helix625-6273
α-helix629-64618
α-helix654-6618
α-helix669-68820
α-helix690-70718
α-helix715-72612
α-helix729-7313
α-helix736-75015
α-helix751-7533
α-helix757-77317
α-helix779-79113
α-helix794-7952
α-helix796-8016
α-helix802-8032
α-helix811-82616
α-helix829-8313
α-helix835-84713
α-helix851-86919
α-helix959-97214
α-helix975-9795
α-helix982-99615
Chain B: 52 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix5-95
α-helix17-215
α-helix221
α-helix23-297
α-helix30-356
α-helix37-459
α-helix52-565
α-helix57-626
α-helix70-734
α-helix76-827
α-helix88-10114
α-helix108-12013
α-helix129-1379
α-helix144-1496
α-helix152-1598
α-helix168-18215
α-helix188-20215
α-helix209-2102
α-helix213-22715
α-helix232-24716
α-helix258-26912
α-helix278-30023
α-helix319-3224
α-helix325-3295
α-helix344-35714
α-helix363-37614
α-helix380-39314
α-helix399-41416
α-helix422-43817
α-helix445-45713
α-helix468-48518
α-helix496-51419
α-helix517-5182
α-helix525-53713
α-helix544-56623
α-helix572-59221
α-helix597-62125
α-helix625-63612
α-helix643-65917
α-helix667-68014
α-helix688-70518
α-helix711-72111
α-helix729-74416
α-helix746-7472
β-strand75011
β-strand75311
α-helix758-77518
α-helix787-7915
α-helix792-7965
α-helix797-80610
α-helix812-82918
α-helix834-8385
α-helix840-85112
α-helix859-87012
Chain C: 4 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix28-3811
α-helix47-5711
α-helix64-685
α-helix69-779
β-strand81-8772
β-strand90-9562

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
MGC52556 proteinAprotein1038Xenopus laevisO42480 (AlphaFold model)
Importin subunit beta-1Bprotein876Homo sapiensQ14974 (AlphaFold model)
Histone H1.0Cprotein194Homo sapiensP07305 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>6N88_1 MGC52556 protein (chains A)
MDPNILIEALRGTMDPALREAAERQLNESHKSLHFVSTLLQITMSEQLELPVRQAGVIYL
KNMITQYWPDREVTPGELPPHTIPEEDRHCIRENIVEAIMHSPELIRVQLTTCIHHIIKH
DYPNRWTAVVEKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLIAAMQHFLPM
LKDRYIQLLADPSEQSVLIQKQIFKIFYALVQYTLPLELINQQNLAEWIEILKTVVDRDV
PAETLQVDEDDRPELPWWKCKKWALHILARLFERYGSPGNVSKEYNDFAEVFLKAFAVGV
QQVLLKVLYQYKEKQYIAPRVLQQTLNYFNQGVSHAVTWKNLKPHIQGIIQDVIFPLMCY
TDSDEDLWQEDPYEYIRMKFDVFEDFISPTTAAQTLLFTSCSKRKEVLQKTMGFCYQILT
EPAADPRKKDGALHMIGSLAEILLKKKIYKDQMEFMLQNHVFPLFSSELGYMRARACWVL
HYFCEVKFKVDQNLQTALELTRRCLIDDREMPVKVEAAIALQVLISNQEKAKEYIVPFIR
PVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQHLAMTFNQVIQTGPDEEG
SDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQHVLEFYEEIFSLAH
SLTCQQVSPQMWQLLPLVFDIFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDTKYLEMIYS
MCKKILTGVAGEDAECHAAKLLEVVILQCKGRGIDQVIPLFVEAALERLTREVKTSELRT
MCLQVAIAALYYSPPLLFNTLENLRFPNNEEPVTNHFIKQWLNDVDCFLGLHDRKICVLG
LCALIELEQRPQVLNQMSSQILPAFLLLFNGLKRAYACHAEQENDSDDDGDGEDDEDAAE
LGSDEDDIDEEGQEYLEILAKQAGEDGDDEDWEDDDAEETALEGYTTLLDDEDTPIDEYQ
IFKAIFQKLQGRDPVWYQALTQGLNEDQGKQLQDIATLADQRRAAHESKMIEKHGGYKFN
APVVPSTFNFGNPAPGMN
Sequence of entity 2 (B), FASTA
>6N88_2 Importin subunit beta-1 (chains B)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sequence of entity 3 (C), FASTA
>6N88_3 Histone H1.0 (chains C)
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKV
GENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATP
KKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVK
PKAKSSAKRAGKKK

Primary citation

Fuzzy Interactions Form and Shape the Histone Transport Complex. Ivic, N., Potocnjak, M., Solis-Mezarino, V. et al. Mol Cell (2019) 73:1191. DOI 10.1016/j.molcel.2019.01.032 · PubMed

Other PDB entries of the same protein (UniProt O42480 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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