6N89: Importin beta:Histone H1.0 complex

Cryo-EM structure of the Importin beta:Histone H1.0 complex. Determined by electron microscopy at 7.5 Å resolution. Released 27 Feb 2019.

Method
Electron microscopy
Resolution
7.5 Å
Organism
Homo sapiens
Chains
2
Atoms
3,788
Mol. weight
118.18 kDa
Released
27 Feb 2019

Explore 6N89 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6N89 contains 53 α-helices and 3 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 50 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix3-97
α-helix15-195
α-helix21-3111
α-helix36-4510
α-helix51-6212
α-helix70-8213
α-helix85-9814
α-helix108-12013
α-helix129-13810
α-helix144-16017
α-helix170-18011
α-helix188-20114
α-helix206-2094
α-helix212-22514
α-helix231-24616
α-helix253-2553
α-helix256-2616
α-helix262-2698
α-helix273-30331
α-helix314-32916
α-helix344-35815
α-helix363-37412
α-helix383-39210
α-helix399-41618
α-helix422-43817
α-helix449-45911
α-helix464-48118
α-helix4941
α-helix500-51314
α-helix521-5233
α-helix524-53714
α-helix545-56117
α-helix571-58717
α-helix599-61315
α-helix615-6173
α-helix627-63913
α-helix650-6578
α-helix665-67713
α-helix687-6893
α-helix690-70112
α-helix711-7155
α-helix717-7215
α-helix732-74413
α-helix755-7584
α-helix761-77515
α-helix785-80420
α-helix812-82817
α-helix833-8375
α-helix843-8519
α-helix857-86913
Chain B: 3 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix28-3811
β-strand4611
α-helix47-559
α-helix64-7714
β-strand81-8771
β-strand90-9561

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Importin subunit beta-1Aprotein876Homo sapiensQ14974 (AlphaFold model)
Histone H1.0Bprotein194Homo sapiensP07305 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>6N89_1 Importin subunit beta-1 (chains A)
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQ
IKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAE
IPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG
MRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQN
LVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCE
DDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDP
SVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEA
AYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSA
KDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDA
LQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKN
YAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDI
ALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQ
ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR
PMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
Sequence of entity 2 (B), FASTA
>6N89_2 Histone H1.0 (chains B)
MTENSTSAPAAKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKV
GENADSQIKLSIKRLVTTGVLKQTKGVGASGSFRLAKSDEPKKSVAFKKTKKEIKKVATP
KKASKPKKAASKAPTKKPKATPVKKAKKKLAATPKKAKKPKTVKAKPVKASKPKKAKPVK
PKAKSSAKRAGKKK

Primary citation

Fuzzy Interactions Form and Shape the Histone Transport Complex. Ivic, N., Potocnjak, M., Solis-Mezarino, V. et al. Mol Cell (2019) 73:1191. DOI 10.1016/j.molcel.2019.01.032 · PubMed

Other PDB entries of the same protein (UniProt Q14974 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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