Crystal structure of smt fusion peptidyl-prolyl cis-trans isomerase from burkholderia pseudomallei complexed with SF339. Determined by X-ray diffraction at 1.85 Å resolution. Released 12 Feb 2020.
Explore 6O49 in 3D Show helices and sheets RCSB PDB PDBe
6O49 contains 15 α-helices and 32 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | -75--69 | 7 | 1 |
| β-strand | -64--58 | 7 | 1 |
| α-helix | -52--43 | 10 | |
| α-helix | -38--36 | 3 | |
| β-strand | -34--31 | 4 | 1 |
| β-strand | -28--27 | 2 | 1 |
| α-helix | -26--25 | 2 | |
| β-strand | -11--6 | 6 | 1 |
| β-strand | 3-5 | 3 | 2 |
| β-strand | 11-16 | 6 | 2 |
| β-strand | 19-22 | 4 | 3 |
| α-helix | 23 | 1 | |
| β-strand | 28-37 | 10 | 2 |
| β-strand | 42-45 | 4 | 2 |
| α-helix | 47-49 | 3 | |
| β-strand | 53-56 | 4 | 2 |
| α-helix | 64-69 | 6 | |
| β-strand | 74-75 | 2 | 3 |
| β-strand | 78-83 | 6 | 2 |
| α-helix | 85-87 | 3 | |
| β-strand | 94 | 1 | 4 |
| β-strand | 98 | 1 | 4 |
| α-helix | 99 | 1 | |
| β-strand | 104-112 | 9 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | -75--69 | 7 | 5 |
| β-strand | -64--58 | 7 | 5 |
| α-helix | -53--43 | 11 | |
| α-helix | -38--36 | 3 | |
| β-strand | -35--31 | 5 | 5 |
| β-strand | -28--27 | 2 | 5 |
| α-helix | -26--25 | 2 | |
| β-strand | -11--5 | 7 | 5 |
| β-strand | 4-5 | 2 | 6 |
| β-strand | 11-16 | 6 | 6 |
| α-helix | 21 | 1 | |
| β-strand | 22 | 1 | 7 |
| α-helix | 23 | 1 | |
| β-strand | 28-37 | 10 | 6 |
| β-strand | 42-45 | 4 | 6 |
| β-strand | 53-56 | 4 | 6 |
| α-helix | 64-69 | 6 | |
| β-strand | 74 | 1 | 7 |
| β-strand | 78-83 | 6 | 6 |
| α-helix | 85-87 | 3 | |
| β-strand | 94 | 1 | 8 |
| β-strand | 98 | 1 | 8 |
| β-strand | 104-112 | 9 | 6 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ubiquitin-like protein SMT3,Peptidyl-prolyl cis-trans isomerase | A, B | protein | 209 | Saccharomyces cerevisiae, Burkholderia pseudomallei (strain 1710b) | Q12306 (AlphaFold model), Q3JK38 (AlphaFold model) |
>6O49_1 Ubiquitin-like protein SMT3,Peptidyl-prolyl cis-trans isomerase (chains A, B) MGHHHHHHSGEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDS LRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGSTVVTTESGLKYEDLTEGSGAEAR AGQTVSVHYTGWLTDGQKFDSSKDRNDPFAFVLGGGMVIKGWDEGVQGMKVGGVRRLTIP PQLGYGARGAGGVIPPNATLVFEVELLDV
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 2 |
| LL7 | (2~{S})-~{N}-[3-oxidanylidene-3-[(3,4,5-trimethoxyphenyl)amino]propyl]-1-(pheny… | C25 H33 N3 O7 S | 2 |
Water and common crystallization additives (EDO) are not listed.
CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339. Iwasaki, J., Lorimer, D.D., Vivoli, M. et al. To be published.
Other PDB entries of the same protein (UniProt Q12306 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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