6RRD: PDB entry 6RRD

RNA Polymerase I Pre-initiation complex DNA opening intermediate 1. Determined by electron microscopy at 3.1 Å resolution. Released 11 Dec 2019.

Method: Electron microscopy
Resolution: 3.1 Å
Organisms: synthetic construct, Saccharomyces cerevisiae
Chains: 20
Atoms: 51,631
Mol. weight: 927.89 kDa
Ligands: ZN
Released: 11 Dec 2019

Explore 6RRD in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6RRD contains 265 α-helices and 309 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 74 helices, 59 β-strands

Element	Residues	Length	Sheet
β-strand	13-18	6	35
α-helix	24-27	4
α-helix	40-42	3
α-helix	43-45	3
α-helix	52-54	3
β-strand	77	1	36
β-strand	80-86	7	37
α-helix	87	1
α-helix	91-99	9
α-helix	114-124	11
α-helix	131-133	3
α-helix	175-196	22
α-helix	210-226	17
α-helix	241-242	2
β-strand	243-245	3	38
β-strand	251-253	3	38
α-helix	258-267	10
β-strand	313-314	2	38
α-helix	317-330	14
α-helix	335-338	4
α-helix	352-354	3
β-strand	356-359	4	37
β-strand	362	1	36
α-helix	365-368	4
β-strand	373	1	39
β-strand	376	1	39
α-helix	381-404	24
α-helix	418-438	21
α-helix	455-458	4
β-strand	474-476	3	40
β-strand	479-486	8	41
β-strand	494-497	4	41
α-helix	499-502	4
β-strand	506-510	5	3
α-helix	511	1
α-helix	516-525	10
β-strand	533-537	5	3
β-strand	543-545	3	3
α-helix	551-558	8
α-helix	563-565	3
β-strand	576-580	5	3
α-helix	581	1
β-strand	586-588	3	41
α-helix	597-599	3
β-strand	602-607	6	41
β-strand	614-616	3	41
α-helix	618-620	3
β-strand	632-636	5	41
α-helix	641-649	9
β-strand	652	1	41
β-strand	658	1	42
β-strand	665	1	42
α-helix	674-680	7
β-strand	686-687	2	43
α-helix	689-697	9
β-strand	719	1	44
β-strand	725	1	44
β-strand	726-727	2	43
α-helix	729-739	11
β-strand	749-752	4	45
β-strand	768-771	4	45
β-strand	776-778	3	45
α-helix	783-786	4
α-helix	793-800	8
α-helix	803-823	21
β-strand	826-827	2	46
α-helix	831-833	3
β-strand	835	1	47
α-helix	837-848	12
α-helix	853-856	4
α-helix	858-861	4
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	47
α-helix	924-930	7
α-helix	937-944	8
β-strand	948-949	2	48
β-strand	952	1	49
β-strand	955	1	49
α-helix	970	1
α-helix	977-979	3
β-strand	981-982	2	48
β-strand	985	1	50
β-strand	989	1	50
α-helix	992-1010	19
α-helix	1017-1026	10
β-strand	1031-1032	2	51
β-strand	1038-1039	2	51
β-strand	1045	1	51
β-strand	1055	1	52
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1077	5
α-helix	1094-1104	11
α-helix	1113-1115	3
α-helix	1123-1126	4
α-helix	1138-1150	13
α-helix	1164-1175	12
β-strand	1178	1	52
α-helix	1179-1180	2
α-helix	1185-1198	14
α-helix	1218-1225	8
β-strand	1238-1241	4	53
β-strand	1242	1	54
α-helix	1248-1255	8
β-strand	1261-1262	2	55
α-helix	1263-1266	4
β-strand	1267-1275	9	23
β-strand	1288-1296	9	23
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1336	15
α-helix	1441-1451	11
β-strand	1460-1462	3	23
β-strand	1469-1476	8	23
α-helix	1486-1493	8
β-strand	1497-1499	3	55
β-strand	1506-1508	3	53
α-helix	1513-1515	3
β-strand	1518-1522	5	53
α-helix	1526-1529	4
β-strand	1536	1	54
α-helix	1538-1540	3
β-strand	1542-1543	2	53
α-helix	1546-1572	27
α-helix	1579-1589	11
α-helix	1609-1613	5
α-helix	1618-1627	10
β-strand	1631-1632	2	35
α-helix	1637-1643	7
α-helix	1650-1652	3
β-strand	1654-1659	6	56

Chain B: 54 helices, 81 β-strands

Element	Residues	Length	Sheet
β-strand	13	1	57
α-helix	18-25	8
α-helix	33	1
α-helix	37-40	4
α-helix	43-50	8
α-helix	56-58	3
α-helix	59-62	4
β-strand	70-73	4	58
α-helix	85-88	4
β-strand	95-104	10	58
α-helix	105-107	3
β-strand	108-109	2	59
β-strand	119-120	2	59
α-helix	125-128	4
β-strand	134-145	12	58
β-strand	150-162	13	58
α-helix	177-181	5
β-strand	194-196	3	60
β-strand	199-203	5	60
β-strand	205-209	5	61
α-helix	210	1
β-strand	215-218	4	62
α-helix	220-225	6
β-strand	229-239	11	62
β-strand	245-251	7	62
β-strand	252	1	63
β-strand	253	1	62
β-strand	258	1	63
β-strand	259-264	6	62
β-strand	267-272	6	62
α-helix	273-280	8
α-helix	287-292	6
α-helix	306-308	3
α-helix	311-316	6
α-helix	323-333	11
α-helix	346-356	11
α-helix	360-362	3
α-helix	367-385	19
α-helix	390-393	4
β-strand	400-403	4	61
α-helix	405-432	28
α-helix	443-450	8
α-helix	458-467	10
β-strand	485-487	3	60
α-helix	493-497	5
β-strand	502	1	64
β-strand	503-504	2	61
α-helix	522-524	3
β-strand	525	1	65
β-strand	528	1	65
β-strand	544	1	64
β-strand	545	1	65
β-strand	550-551	2	66
α-helix	555-556	2
α-helix	561-565	5
α-helix	570	1
β-strand	571-572	2	67
α-helix	573-575	3
β-strand	584-588	5	67
β-strand	591-596	6	67
α-helix	598-613	16
β-strand	625-629	5	67
α-helix	637-638	2
β-strand	639-643	5	67
β-strand	649-650	2	66
β-strand	651-655	5	68
β-strand	661-664	4	68
β-strand	674-675	2	68
α-helix	678-680	3
β-strand	688-689	2	68
α-helix	693-696	4
β-strand	710	1	69
α-helix	712-723	12
β-strand	725	1	70
α-helix	733-735	3
β-strand	740-744	5	71
β-strand	748	1	72
β-strand	752-753	2	57
α-helix	756-759	4
α-helix	762-764	3
β-strand	768	1	72
β-strand	769-775	7	73
β-strand	776-777	2	46
β-strand	787-790	4	73
α-helix	791-795	5
β-strand	801-810	10	71
β-strand	824-825	2	74
α-helix	836-839	4
β-strand	840	1	75
β-strand	846	1	75
α-helix	847	1
β-strand	852	1	76
β-strand	856-863	8	74
β-strand	868-874	7	74
β-strand	880	1	76
β-strand	884-888	5	71
β-strand	900-909	10	71
β-strand	913	1	77
β-strand	915	1	77
β-strand	916-919	4	73
β-strand	925-931	7	73
α-helix	933-935	3
β-strand	938-939	2	78
β-strand	947-949	3	73
α-helix	951-953	3
α-helix	954-957	4
β-strand	959	1	69
α-helix	961-975	15
β-strand	979-980	2	57
α-helix	992-1003	12
β-strand	1010-1011	2	73
β-strand	1013-1014	2	78
β-strand	1021	1	78
α-helix	1022	1
β-strand	1026-1035	10	73
β-strand	1036	1	70
α-helix	1040-1042	3
β-strand	1045-1047	3	41
β-strand	1052	1	79
β-strand	1059	1	79
α-helix	1060-1061	2
α-helix	1067-1068	2
β-strand	1069-1071	3	40
α-helix	1073-1081	9
α-helix	1085-1089	5
α-helix	1090-1094	5
β-strand	1098-1104	7	80
β-strand	1113-1115	3	81
β-strand	1126-1128	3	81
β-strand	1132-1134	3	82
β-strand	1158-1160	3	82
β-strand	1166-1169	4	82
β-strand	1173-1179	7	80
α-helix	1181-1191	11
β-strand	1194-1199	6	35

Chain C: 12 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	35-39	5
β-strand	41	1	83
β-strand	44-47	4	84
β-strand	52-56	5	84
β-strand	57	1	83
α-helix	61-73	13
β-strand	77-88	12	85
α-helix	94-102	9
α-helix	105	1
β-strand	106	1	86
α-helix	108-109	2
α-helix	122-125	4
β-strand	132-139	8	85
β-strand	141-142	2	87
β-strand	157-158	2	87
β-strand	161-163	3	88
α-helix	164-166	3
β-strand	168-170	3	85
α-helix	175-178	4
β-strand	186	1	86
β-strand	192-195	4	88
β-strand	201-211	11	85
α-helix	217-219	3
β-strand	226-235	10	84
α-helix	243-246	4
β-strand	256-257	2	89
β-strand	266-267	2	89
α-helix	270-272	3
β-strand	289-302	14	84
α-helix	312-329	18
β-strand	334	1	90

Chain D: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	8-11	4
β-strand	22-24	3	56
β-strand	29-30	2	91
α-helix	33-44	12
α-helix	83-95	13

Chain E: 12 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	5-25	21
β-strand	28	1	92
α-helix	32-35	4
α-helix	39-45	7
β-strand	60-62	3	93
β-strand	64	1	92
α-helix	66-71	6
β-strand	78-82	5	93
β-strand	87-88	2	94
α-helix	90-103	14
β-strand	107-112	6	93
β-strand	115-116	2	94
α-helix	121-126	6
β-strand	131-136	6	93
α-helix	144-146	3
β-strand	152-155	4	95
α-helix	158-167	10
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	95
α-helix	183-188	6
α-helix	194	1
β-strand	195-202	8	95
β-strand	206-214	9	95

Chain F: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	56-71	16
β-strand	73	1	56
α-helix	74-75	2
β-strand	84	1	96
α-helix	89-101	13
α-helix	117-126	10
β-strand	132-137	6	56
β-strand	143-147	5	56
β-strand	152	1	96

Chain G: 6 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	9-12	4
α-helix	14-20	7
β-strand	28	1	97
β-strand	35	1	97
β-strand	38	1	98
β-strand	39-40	2	91
β-strand	41-49	9	56
α-helix	57-61	5
α-helix	62-66	5
α-helix	67-69	3
β-strand	73	1	98
β-strand	80	1	98
β-strand	84-89	6	56
α-helix	90-91	2
β-strand	104-107	4	56
β-strand	114-122	9	56
β-strand	125	1	98
β-strand	132-133	2	99
β-strand	136-140	5	99
β-strand	144-149	6	99
β-strand	153-158	6	99
β-strand	167	1	100
β-strand	218	1	100
β-strand	224	1	100
β-strand	231-237	7	99
β-strand	244-248	5	99

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	44
β-strand	23-30	8	44
β-strand	37-43	7	44
β-strand	54-60	7	44
α-helix	89-92	4
β-strand	95-108	14	44
β-strand	111-118	8	44
β-strand	121-126	6	44
β-strand	140-145	6	44

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Template strand	T	DNA	70	synthetic construct
Nontemplate strand	U	DNA	70	synthetic construct
RNA polymerase I-specific transcription initiation factor RRN7	Q	protein	514	Saccharomyces cerevisiae	P40992 (AlphaFold model)
RNA polymerase I-specific transcription initiation factor RRN6	S	protein	894	Saccharomyces cerevisiae	P32786 (AlphaFold model)
RNA polymerase I-specific transcription initiation factor RRN11	R	protein	507	Saccharomyces cerevisiae	Q04712 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae	P32529 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA34	N	protein	233	Saccharomyces cerevisiae	P47006
DNA-directed RNA polymerase I subunit RPA49	M	protein	415	Saccharomyces cerevisiae	Q01080
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106

8 more molecules are not listed.

Sequence of entity 1 (T), FASTA

>6RRD_1 Template strand (chains T)
GTCTTCAACTGCTTTCGCATGAAGTACCTCCCAACTACTTTTCCTCACACTTGTACTCCA
TGACTAAACC

Sequence of entity 2 (U), FASTA

>6RRD_2 Nontemplate strand (chains U)
GGTTTAGTCATGGAGTACAAGTGTGAGGAAAAGTAGTTGGGAGGTACTTCATGCGAAAGC
AGTTGAAGAC

Sequence of entity 3 (Q), FASTA

>6RRD_3 RNA polymerase I-specific transcription initiation factor RRN7 (chains Q)
MSTFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDEDDLNGLGAGVITRRL
NLTTNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKLLFLKSFQFILKRQIRWLI
TEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTSTISILYLASTHLSLPVYTCD
YIKWICTAKMPYFQASEILPKSWRIQLPNYYVSILEGSISPFNGQLYNKIALTCGMIHFK
EFFNSEISCQGLLLKLVMQCALPPEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSN
HAELRVLSYFMLTINWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGRNIVKVVYPDK
PTSSDYFQWSEEETLEFLKWMEKQFLPTQTKSLHNENGSMEMTIDQKIARRKLYKIFPLD
REANHDGEFNDSTHQLTFIEDLQERYAKQTPFFESNKIRDSLNYQEANPPARKEAIGRLL
THIASQLLVDFAISKEQLKDCISRIKNACLHRMN

Sequence of entity 4 (S), FASTA

>6RRD_4 RNA polymerase I-specific transcription initiation factor RRN6 (chains S)
MSEGQIPSSDVLGSQLGVGVQGASLYCPQENYTTKKQEKPQWLRPVDDTLAEDALDLHIV
VKSLLCDTAIRYISDDKVLQESDADDDLITSDIDEDTDNQGDTSIVVNPVIPVVPKDVHF
FKKVDVGNDSMFGVNCDTPVSFQDYIPSDLLRNLDDTLQESTNSSRPMQDAFFWDPTVAN
RLDSQYIQTASDLRNYRDGTEIIAYASGKTGSVLNIAVLTRQNTLHLNRHNNVTSIELHS
PIKSIKIPGASESIGRRSNLVGIITENSFQIFRIESVHSRSCDVMVSSSEPLYFVEIDDL
QVVDFAFNPWDLQQFAIIDIKGNWSIGRIPKNFNNNNKRKLQLIDNLHGTIFDPEELSSW
KRIEWFSHFQKILVFDRSKMIEIDFMNNWQTEVVQAKAWSNIRDYKRIDDKNGILLTSRE
IIIVGASESNDPVRRISWKHDLDPDDTTLRITVQKVKKPDHILLVAFVYSMRHKRIYMHV
FSHRKANLFQSLGCSTVLEIPGGTPTGIETILTLDHIDDESRREEDADENFELVVDFLVK
LRNSSEVYYYALSNTQNSEPNKQETPIIVDHPEWASLFNNADEREKESIGALVSQIKLKE
RERISRVQNLIEHENSHDEDKYLQDLGYRLSIATNELLESWQKTKDESILSGSLSHSKLK
NLLENSDSFASIPEFSSLLDQFFQYYQDQDVTFIGFEKLLHLFLHEDVPGLDIFYNKLLQ
CWVLVSPQAELLTKEIVKDIIWSLARLEKPSLFEPIQNEISRSLSGPYQDIISSWDMDDI
NEEDESNEFNFDSQFSAPFNGRPPFNLNSQSQIPTIKSSQSSGLARRKRILKTQSQKATP
LSQSTQNLSVLPDSMTPAFTLMQPPSSQISFVNDSQPRNSQKAKKKKKRIRGFG

Sequence of entity 5 (R), FASTA

>6RRD_5 RNA polymerase I-specific transcription initiation factor RRN11 (chains R)
MFEVPITLTNRKFAQRRKLKYQYINYISRRFDRISKKSTTTDSLPTPENSAAENNDEEEG
QNSEAGTYRRSVLQQKKRRRERHWRSVVGEIYSTTESETDSQEEETEEGGEHDTGIDKED
SDEERKFWKKYEKPEKSFEIWRTVSSQNKQPINKQKMTYHNFKKIEKIPLRKMEIPLLHC
TKENKLYFQSISRGLEPLKTSTSEVRNYRTRHIVTLTDLLHLNVSRHNWSLAYKIFATLI
RIPGVQIKSLWGIGVEILDNLSNSSSGLDFLQWMCQIYSSKSRFVQNINYRSIVPPFQTG
SRTHTAKFAITYLWSSLINCQKSMEPSSNIIDKPFDTENDLLQELIDKISEWVLTPPFME
DAEVWFIYASCHLLKADTLSRQFVNDNKNNDLIGLDRDIKINQVIKHIHYVRTFLKICLD
KGGFAVPSRLIENQLKSFESRLYGEAQDIQERDVANVYDSIDNSSVENSFGDVYETNAEF
LDTQLMDLSPEDNGLDEMHYSDEDSSE

Sequence of entity 6 (I), FASTA

>6RRD_6 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 7 (N), FASTA

>6RRD_7 DNA-directed RNA polymerase I subunit RPA34 (chains N)
MSKLSKDYVSDSDSDDEVISNEFSIPDGFKKCKHLKNFPLNGDNKKKAKQQQVWLIKFPS
NVDISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQDNLSNMTLLVPSESKESLK
IASTAKDNAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDVPKVEGLKLEHFATGYDAEDF
HVAEEVKENKKEPKKRSHHDDEEESSEKKKKKKEKREKREKKDKKDKKKKHRD

Sequence of entity 8 (M), FASTA

>6RRD_8 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERL
EYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTR
PSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDE
ITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNS
KYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILS
RFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKV
VSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Sequence of entity 9 (A), FASTA

>6RRD_9 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 10 (B), FASTA

>6RRD_10 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 11 (C), FASTA

>6RRD_11 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 12 (D), FASTA

>6RRD_12 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

Molecular insight into RNA polymerase I promoter recognition and promoter melting. Sadian, Y., Baudin, F., Tafur, L. et al. Nat Commun (2019) 10:5543-5543. DOI 10.1038/s41467-019-13510-w · PubMed

Other PDB entries of the same protein (UniProt P40992 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
5O7X 3.2 Å, Crystal structure of S. Cerevisiae core factor at 3.2A resolution
5N61 3.4 Å, RNA polymerase I initially transcribing complex
6RUO 3.5 Å, RNA Polymerase I Open Complex conformation 1
6TPS 3.54 Å, early intermediate RNA Polymerase I Pre-initiation complex - eiPIC
6RQH 3.7 Å, RNA Polymerase I Closed Conformation 1 (CC1)
5W5Y 3.8 Å, RNA polymerase I Initial Transcribing Complex
5W66 3.9 Å, RNA polymerase I Initial Transcribing Complex State 3
5W64 4.2 Å, RNA Polymerase I Initial Transcribing Complex State 1
5W65 4.3 Å, RNA polymerase I Initial Transcribing Complex State 2

Browse structure collections

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