5W65: DNA-directed RNA polymerase I subunit RPA190

Name: PDB 5W65: RNA polymerase I Initial Transcribing Complex State 2
Published: 2017-08-02
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

RNA polymerase I Initial Transcribing Complex State 2. Determined by electron microscopy at 4.3 Å resolution. Released 2 Aug 2017.

Method: Electron microscopy
Resolution: 4.3 Å
Organisms: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae S288c
Chains: 20
Atoms: 47,308
Mol. weight: 846.28 kDa
Ligands: ZN
Released: 2 Aug 2017

Explore 5W65 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5W65 contains 265 α-helices and 286 β-strands across 17 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 88 helices, 71 β-strands

Element	Residues	Length	Sheet
β-strand	14-18	5	1
α-helix	21-27	7
β-strand	31	1	2
β-strand	34	1	3
β-strand	38-39	2	4
β-strand	43-44	2	4
α-helix	45	1
β-strand	48	1	3
α-helix	52-54	3
β-strand	57	1	5
β-strand	60	1	5
α-helix	61-62	2
β-strand	77-79	3	2
β-strand	85-86	2	6
α-helix	88-100	13
β-strand	101	1	7
β-strand	108	1	7
α-helix	112-126	15
α-helix	130-135	6
α-helix	136-138	3
α-helix	175-198	24
α-helix	210-229	20
α-helix	240-242	3
β-strand	243-245	3	8
β-strand	251-253	3	8
α-helix	258-266	9
β-strand	313-315	3	8
α-helix	317-330	14
α-helix	332-338	7
α-helix	352-354	3
β-strand	356-357	2	6
β-strand	360-362	3	2
α-helix	365-368	4
β-strand	371-373	3	9
β-strand	376-378	3	9
α-helix	379-380	2
α-helix	381-406	26
α-helix	417-438	22
α-helix	440-442	3
α-helix	456-460	5
α-helix	465-466	2
α-helix	467-471	5
β-strand	474-475	2	10
β-strand	479-486	8	11
β-strand	494-497	4	11
α-helix	499-502	4
β-strand	506-510	5	12
α-helix	516-525	10
β-strand	533-537	5	12
β-strand	543-545	3	12
α-helix	551-558	8
β-strand	576-580	5	12
α-helix	581	1
β-strand	586-590	5	11
α-helix	597-599	3
β-strand	600-607	8	11
β-strand	614-616	3	11
α-helix	618-620	3
α-helix	621-624	4
β-strand	632-636	5	11
α-helix	641-649	9
β-strand	652	1	11
α-helix	653-656	4
β-strand	658	1	13
β-strand	665	1	13
α-helix	671-680	10
β-strand	686-687	2	14
α-helix	689-699	11
α-helix	702-704	3
α-helix	715-717	3
β-strand	719	1	15
β-strand	725	1	15
β-strand	726-727	2	14
α-helix	728-739	12
α-helix	745-747	3
β-strand	749-751	3	16
α-helix	757-760	4
β-strand	769-772	4	16
β-strand	775-778	4	16
α-helix	783-786	4
α-helix	793-801	9
α-helix	803-824	22
β-strand	826-827	2	17
α-helix	830-833	4
α-helix	834	1
β-strand	835	1	18
α-helix	836	1
α-helix	837-847	11
α-helix	850-862	13
α-helix	873-884	12
α-helix	886-915	30
β-strand	916	1	18
α-helix	924-931	8
α-helix	937-944	8
β-strand	948-949	2	19
β-strand	952	1	20
β-strand	955	1	20
α-helix	970	1
α-helix	977-979	3
β-strand	981-982	2	19
β-strand	985	1	21
β-strand	989	1	21
α-helix	992-1027	36
β-strand	1030-1032	3	22
β-strand	1038-1040	3	22
β-strand	1045-1047	3	22
α-helix	1050-1052	3
β-strand	1055	1	23
α-helix	1057-1063	7
α-helix	1066-1071	6
α-helix	1073-1079	7
α-helix	1082-1084	3
β-strand	1090	1	24
α-helix	1093-1107	15
α-helix	1123-1126	4
β-strand	1132	1	24
α-helix	1138-1150	13
α-helix	1163-1176	14
β-strand	1178	1	23
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1195-1198	4
α-helix	1218-1222	5
α-helix	1223-1227	5
β-strand	1238-1241	4	25
β-strand	1242	1	26
α-helix	1248-1258	11
β-strand	1261-1262	2	27
α-helix	1263-1266	4
β-strand	1267-1275	9	28
β-strand	1288-1296	9	28
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1336	15
α-helix	1441-1453	13
β-strand	1457	1	28
β-strand	1461-1462	2	28
β-strand	1469-1476	8	28
α-helix	1478-1480	3
α-helix	1485-1493	9
β-strand	1497-1499	3	27
β-strand	1504-1508	5	25
α-helix	1510-1512	3
β-strand	1518-1523	6	25
α-helix	1526-1530	5
β-strand	1536	1	26
α-helix	1538-1540	3
β-strand	1542-1543	2	25
α-helix	1546-1553	8
α-helix	1555-1572	18
α-helix	1579-1589	11
α-helix	1600-1604	5
α-helix	1609-1613	5
α-helix	1618-1628	11
β-strand	1631-1632	2	1
α-helix	1637-1642	6
α-helix	1650-1652	3
β-strand	1654-1661	8	29

Chain B: 61 helices, 78 β-strands

Element	Residues	Length	Sheet
α-helix	19-26	8
α-helix	36-41	6
α-helix	43-50	8
α-helix	60-68	9
β-strand	74	1	30
β-strand	94	1	30
β-strand	97-104	8	31
β-strand	108-109	2	32
β-strand	119-120	2	32
α-helix	123-129	7
β-strand	134-145	12	31
α-helix	146-148	3
β-strand	150-162	13	31
α-helix	163-164	2
α-helix	171-174	4
α-helix	177-182	6
β-strand	194-196	3	33
β-strand	199-203	5	33
α-helix	204	1
β-strand	205-209	5	34
α-helix	210	1
β-strand	211	1	35
β-strand	215-218	4	35
α-helix	220-224	5
β-strand	229-239	11	35
β-strand	245-253	9	35
β-strand	258-264	7	35
β-strand	267-272	6	35
α-helix	273-280	8
α-helix	285-292	8
α-helix	300-316	17
α-helix	323-338	16
α-helix	346-357	12
α-helix	360-362	3
α-helix	367-386	20
α-helix	397-399	3
β-strand	400-403	4	34
α-helix	405-432	28
α-helix	443-450	8
α-helix	457-467	11
α-helix	475-477	3
β-strand	485-487	3	33
α-helix	493-499	7
β-strand	502-504	3	34
α-helix	507-511	5
α-helix	520-521	2
α-helix	522-524	3
β-strand	528	1	36
β-strand	542-544	3	34
β-strand	545	1	36
β-strand	550-551	2	37
α-helix	558-560	3
α-helix	561-568	8
α-helix	570	1
β-strand	571-572	2	38
α-helix	573-576	4
β-strand	584-588	5	38
β-strand	591-596	6	38
α-helix	598-613	16
β-strand	625-629	5	38
α-helix	637-638	2
β-strand	639-643	5	38
β-strand	649-650	2	37
β-strand	651-655	5	39
β-strand	660-664	5	39
α-helix	666-669	4
β-strand	674-675	2	39
α-helix	678-680	3
α-helix	681-682	2
β-strand	688-689	2	39
α-helix	693-696	4
α-helix	699-703	5
α-helix	707-709	3
α-helix	712-723	12
β-strand	725	1	40
β-strand	727	1	41
α-helix	733-735	3
β-strand	740-744	5	41
β-strand	748	1	42
β-strand	752-753	2	43
α-helix	755-759	5
α-helix	762-764	3
β-strand	768	1	42
β-strand	769-775	7	44
β-strand	776-777	2	17
β-strand	786-790	5	44
α-helix	791-795	5
β-strand	801-810	10	41
α-helix	816-818	3
β-strand	824	1	45
α-helix	834-838	5
β-strand	840	1	46
β-strand	846	1	46
α-helix	847	1
β-strand	851-852	2	41
β-strand	857-863	7	45
β-strand	868-873	6	45
β-strand	880-888	9	41
β-strand	900-909	10	41
β-strand	916-919	4	44
β-strand	924-931	8	44
α-helix	933-935	3
β-strand	938-939	2	47
β-strand	947-949	3	44
α-helix	951-953	3
α-helix	954-957	4
α-helix	960-975	16
β-strand	979-980	2	43
β-strand	987	1	48
β-strand	990	1	48
α-helix	992-1003	12
β-strand	1010-1011	2	44
β-strand	1013-1014	2	47
α-helix	1020	1
β-strand	1021	1	47
α-helix	1022	1
β-strand	1026-1035	10	44
β-strand	1036	1	40
β-strand	1045-1047	3	11
β-strand	1052	1	49
β-strand	1059	1	49
α-helix	1063-1065	3
β-strand	1070-1071	2	10
α-helix	1073-1081	9
α-helix	1085-1089	5
α-helix	1090-1094	5
β-strand	1098-1104	7	50
β-strand	1113-1115	3	51
α-helix	1116	1
β-strand	1117	1	52
β-strand	1119	1	53
β-strand	1122	1	53
β-strand	1126-1128	3	51
β-strand	1132-1134	3	52
β-strand	1151-1153	3	52
β-strand	1159-1162	4	52
β-strand	1166-1172	7	50
α-helix	1173-1184	12
β-strand	1187-1191	5	1

Chain C: 16 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-47	7	54
β-strand	51-57	7	54
α-helix	61-73	13
β-strand	76-88	13	55
α-helix	94-103	10
α-helix	105	1
β-strand	106-107	2	56
α-helix	110-112	3
α-helix	114-116	3
α-helix	122-125	4
β-strand	131-139	9	55
β-strand	141-142	2	57
α-helix	153-156	4
β-strand	157-158	2	57
β-strand	161-163	3	58
α-helix	164-166	3
β-strand	168-170	3	55
α-helix	174-178	5
β-strand	185-186	2	56
β-strand	192-195	4	58
β-strand	201-212	12	55
α-helix	217-219	3
β-strand	222-235	14	54
α-helix	241-248	8
α-helix	270-272	3
α-helix	278-281	4
α-helix	283-286	4
β-strand	289-304	16	54
α-helix	310-330	21
β-strand	334	1	59

Chain D: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	29
β-strand	29	1	29
α-helix	33-48	16
α-helix	82-95	14

Chain E: 14 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	2-26	25
β-strand	28	1	60
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	61
β-strand	53	1	61
α-helix	55-58	4
β-strand	60-62	3	62
β-strand	64	1	60
α-helix	66-71	6
β-strand	78-82	5	62
β-strand	87-88	2	63
α-helix	90-103	14
β-strand	107-112	6	62
β-strand	115-116	2	63
α-helix	118-123	6
β-strand	131-136	6	62
α-helix	144-146	3
β-strand	152-155	4	64
α-helix	156-157	2
α-helix	158-167	10
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	64
α-helix	183-188	6
α-helix	190-191	2
β-strand	195-202	8	64
β-strand	206-214	9	64

Chain F: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	73	1	29
α-helix	76-78	3
β-strand	84	1	65
α-helix	85-86	2
α-helix	87-102	16
α-helix	105-107	3
α-helix	117-126	10
β-strand	132-137	6	29
β-strand	143-147	5	29
β-strand	152	1	65

Chain G: 8 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	11-19	9
α-helix	26-27	2
β-strand	28	1	66
α-helix	29-31	3
β-strand	35	1	66
β-strand	38-49	12	29
α-helix	51-53	3
α-helix	57-61	5
α-helix	62-66	5
β-strand	72-74	3	29
β-strand	79-89	11	29
β-strand	102-107	6	29
α-helix	108	1
β-strand	114-125	12	29
β-strand	132-141	10	67
β-strand	144-149	6	67
β-strand	153-158	6	67
α-helix	159-161	3
β-strand	167-169	3	68
β-strand	216-218	3	68
β-strand	224	1	68
β-strand	228-237	10	67
β-strand	244-248	5	67

Chain H: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	15
β-strand	23-30	8	15
β-strand	37-43	7	15
β-strand	54-60	7	15
α-helix	89-91	3
β-strand	95-106	12	15
β-strand	112-118	7	15
β-strand	121-127	7	15
α-helix	130-133	4
β-strand	140-145	6	15

9 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P40422

8 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>5W65_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>5W65_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>5W65_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>5W65_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>5W65_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>5W65_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>5W65_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>5W65_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>5W65_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>5W65_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>5W65_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>5W65_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7

Primary citation

Structural mechanism of ATP-independent transcription initiation by RNA polymerase I. Han, Y., Yan, C., Nguyen, T.H.D. et al. Elife (2017) 6. DOI 10.7554/eLife.27414 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

Browse structure collections

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