RNA polymerase I-specific transcription initiation factor RRN6 (RRN6) is a 894-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P32786.
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The mean pLDDT of this model is 67.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 16% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
Acts as a component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex
Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN6 interacts with RRN7, RRN11 and RRN9
Cytoplasm, Nucleus, nucleolus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6RUI | EM | 2.7 Å | S=1-894 |
| 6RQL | EM | 2.9 Å | S=1-894 |
| 6RWE | EM | 3.0 Å | S=1-894 |
| 6RRD | EM | 3.1 Å | S=1-894 |
| 5O7X | X-ray | 3.2 Å | A/D/G/J/M/P=1-894 |
| 5N61 | EM | 3.4 Å | P=1-894 |
| 6RUO | EM | 3.5 Å | S=1-894 |
| 6TPS | EM | 3.54 Å | P=169-779 |
| 6RQH | EM | 3.7 Å | S=1-894 |
| 5W5Y | EM | 3.8 Å | O=1-894 |
| 5W66 | EM | 3.9 Å | O=1-894 |
| 5W64 | EM | 4.2 Å | O=1-894 |
| 5W65 | EM | 4.3 Å | O=1-894 |
| 5OA1 | EM | 4.4 Å | V=1-894 |
| 5N5Y | EM | 7.7 Å | P=1-894 |
| 5N5Z | EM | 7.7 Å | P=1-894 |
| 5N60 | EM | 7.7 Å | P=1-894 |
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