5N61: RNA polymerase I initially transcribing complex

RNA polymerase I initially transcribing complex. Determined by electron microscopy at 3.4 Å resolution. Released 5 Apr 2017.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae
Chains: 21
Atoms: 48,547
Mol. weight: 913.43 kDa
Ligands: ZN, MG
Released: 5 Apr 2017

Explore 5N61 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5N61 contains 261 α-helices and 270 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 80 helices, 63 β-strands

Element	Residues	Length	Sheet
β-strand	10-18	9	1
α-helix	21-27	7
β-strand	31	1	2
β-strand	38	1	3
α-helix	43	1
β-strand	44	1	3
α-helix	45	1
α-helix	52-54	3
β-strand	57	1	4
β-strand	60	1	4
α-helix	61-62	2
β-strand	77-79	3	2
α-helix	92-99	8
β-strand	101	1	5
β-strand	108	1	5
α-helix	112-126	15
α-helix	130-137	8
α-helix	175-198	24
α-helix	210-229	20
α-helix	240-241	2
β-strand	242-244	3	6
β-strand	252-254	3	6
α-helix	255-257	3
α-helix	258-267	10
β-strand	313-314	2	6
α-helix	317-338	22
α-helix	348-350	3
α-helix	353-356	4
β-strand	360-362	3	2
α-helix	365-368	4
β-strand	371-373	3	7
β-strand	376-378	3	7
α-helix	381-405	25
α-helix	413-438	26
α-helix	444-445	2
α-helix	452-454	3
α-helix	456-460	5
α-helix	462-464	3
α-helix	467-471	5
β-strand	475-476	2	8
β-strand	479-486	8	9
β-strand	494-497	4	9
α-helix	499-504	6
β-strand	506-510	5	10
α-helix	516-525	10
β-strand	533-537	5	10
β-strand	543-545	3	10
α-helix	551-561	11
β-strand	576-580	5	10
α-helix	581	1
β-strand	586-590	5	9
α-helix	597-599	3
β-strand	600-607	8	9
β-strand	614-616	3	9
α-helix	621-624	4
β-strand	632-636	5	9
α-helix	641-649	9
β-strand	658	1	11
β-strand	665	1	11
α-helix	672-681	10
β-strand	686-687	2	12
α-helix	689-699	11
α-helix	715-717	3
β-strand	719-721	3	13
β-strand	725	1	13
β-strand	726-727	2	12
α-helix	728-739	12
α-helix	745-747	3
β-strand	749-751	3	14
α-helix	757-759	3
β-strand	769-771	3	14
β-strand	776-778	3	14
α-helix	783-786	4
α-helix	793-801	9
α-helix	803-824	22
α-helix	830-833	4
β-strand	835	1	15
α-helix	837-848	12
α-helix	853-861	9
α-helix	873-884	12
α-helix	886-911	26
β-strand	916	1	15
α-helix	924-931	8
α-helix	937-944	8
β-strand	952	1	16
β-strand	955	1	16
β-strand	985	1	17
β-strand	989	1	17
α-helix	992-1027	36
β-strand	1031-1032	2	18
β-strand	1038-1039	2	18
β-strand	1045	1	18
β-strand	1055	1	19
α-helix	1057-1059	3
α-helix	1061-1064	4
α-helix	1066-1070	5
α-helix	1073-1080	8
α-helix	1082-1085	4
β-strand	1090	1	20
α-helix	1092-1107	16
α-helix	1121-1122	2
α-helix	1123-1126	4
β-strand	1132	1	20
α-helix	1138-1150	13
α-helix	1152-1157	6
α-helix	1163-1176	14
β-strand	1178	1	19
α-helix	1179-1180	2
α-helix	1185-1199	15
α-helix	1218-1223	6
α-helix	1224-1228	5
β-strand	1237-1241	5	21
β-strand	1242	1	22
α-helix	1248-1257	10
β-strand	1260-1262	3	23
α-helix	1263-1266	4
β-strand	1267-1273	7	24
β-strand	1289-1296	8	24
α-helix	1299-1305	7
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1335	14
α-helix	1442-1453	12
β-strand	1457-1462	6	24
β-strand	1469-1475	7	24
α-helix	1485-1495	11
β-strand	1497-1500	4	23
β-strand	1501	1	25
β-strand	1504	1	25
α-helix	1513-1515	3
β-strand	1518-1522	5	21
α-helix	1526-1530	5
β-strand	1536	1	22
α-helix	1538-1540	3
β-strand	1542-1543	2	21
α-helix	1546-1572	27
α-helix	1579-1589	11
α-helix	1600-1603	4
α-helix	1609-1615	7
α-helix	1618-1627	10
β-strand	1631-1632	2	1
α-helix	1637-1643	7
β-strand	1654-1658	5	26

Chain B: 49 helices, 72 β-strands

Element	Residues	Length	Sheet
α-helix	18-26	9
α-helix	36-53	18
α-helix	59-68	10
β-strand	71-74	4	27
β-strand	94-104	11	27
α-helix	105-107	3
β-strand	108-109	2	28
β-strand	116	1	29
α-helix	117-118	2
β-strand	119-120	2	28
α-helix	123-128	6
β-strand	134-145	12	27
β-strand	150-162	13	27
α-helix	177-182	6
β-strand	194-196	3	30
β-strand	199-203	5	30
β-strand	205-208	4	31
α-helix	209-210	2
β-strand	211	1	32
β-strand	215-218	4	32
α-helix	220-224	5
β-strand	229-239	11	32
β-strand	245-253	9	32
β-strand	258-264	7	32
β-strand	267-272	6	32
α-helix	273-280	8
α-helix	285-293	9
α-helix	296-298	3
α-helix	301-313	13
α-helix	323-338	16
α-helix	346-357	12
α-helix	360-362	3
α-helix	367-385	19
α-helix	397-399	3
β-strand	401-403	3	31
α-helix	405-433	29
α-helix	443-452	10
α-helix	457-467	11
β-strand	469	1	33
β-strand	482	1	33
β-strand	485-487	3	30
α-helix	493-500	8
β-strand	502-504	3	31
α-helix	507-510	4
α-helix	516-518	3
α-helix	522-524	3
β-strand	528	1	34
β-strand	543-544	2	31
β-strand	545	1	34
α-helix	560-567	8
α-helix	570	1
β-strand	571-572	2	35
β-strand	584-588	5	35
β-strand	592-596	5	35
α-helix	598-614	17
β-strand	629	1	36
β-strand	639	1	36
β-strand	640-642	3	35
β-strand	651-655	5	37
β-strand	660-664	5	37
α-helix	666-669	4
β-strand	674-675	2	37
α-helix	678-680	3
β-strand	688-689	2	37
α-helix	693-696	4
α-helix	699-703	5
α-helix	712-722	11
β-strand	725	1	38
α-helix	733-735	3
β-strand	740-744	5	39
β-strand	748	1	40
β-strand	752-753	2	41
α-helix	755-756	2
α-helix	757-761	5
α-helix	762-764	3
β-strand	769-775	7	42
β-strand	788-790	3	42
α-helix	791-795	5
β-strand	801-810	10	39
β-strand	823-825	3	43
α-helix	836-839	4
β-strand	840	1	44
β-strand	846	1	44
α-helix	847	1
β-strand	851-852	2	39
β-strand	857-863	7	43
β-strand	868-873	6	43
β-strand	880-888	9	39
β-strand	900-909	10	39
β-strand	916-919	4	42
β-strand	924-926	3	42
β-strand	929-931	3	42
α-helix	933-935	3
β-strand	938-939	2	45
β-strand	947-949	3	42
α-helix	961-975	15
β-strand	979-980	2	41
α-helix	992-1003	12
β-strand	1010-1011	2	42
β-strand	1013-1014	2	45
β-strand	1021	1	45
α-helix	1022	1
β-strand	1026-1035	10	42
β-strand	1036	1	38
α-helix	1040-1042	3
β-strand	1045-1046	2	9
β-strand	1053	1	46
β-strand	1058	1	46
β-strand	1069-1070	2	8
α-helix	1073-1082	10
α-helix	1085-1094	10
β-strand	1101-1104	4	47
β-strand	1113-1115	3	48
β-strand	1126-1128	3	48
β-strand	1132-1134	3	49
α-helix	1135-1139	5
β-strand	1158-1160	3	49
β-strand	1166-1169	4	49
β-strand	1173-1176	4	47
α-helix	1180-1191	12
β-strand	1194-1201	8	1

Chain C: 13 helices, 21 β-strands

Element	Residues	Length	Sheet
α-helix	33-39	7
β-strand	41-47	7	50
β-strand	52-57	6	50
α-helix	61-72	12
β-strand	76-88	13	51
α-helix	94-102	9
β-strand	106-107	2	52
α-helix	110-112	3
α-helix	122-125	4
β-strand	132-139	8	51
β-strand	141-142	2	53
α-helix	153-156	4
β-strand	157-158	2	53
β-strand	161-163	3	54
α-helix	164-166	3
α-helix	167	1
β-strand	168-170	3	51
α-helix	175-178	4
β-strand	185-186	2	52
β-strand	192-195	4	54
β-strand	201-212	12	51
β-strand	225-226	2	50
β-strand	231	1	55
β-strand	234-235	2	56
α-helix	242-249	8
β-strand	256-258	3	57
β-strand	265-267	3	57
α-helix	279-281	3
α-helix	283-286	4
β-strand	289-290	2	56
β-strand	293	1	55
β-strand	297-302	6	50
α-helix	310-330	21
β-strand	334	1	58

Chain D: 2 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	21-24	4	26
β-strand	29-30	2	26
α-helix	33-46	14
α-helix	81-95	15

Chain E: 13 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	5-25	21
β-strand	28-29	2	59
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	60
β-strand	53	1	60
α-helix	55-58	4
β-strand	60-62	3	61
β-strand	63-64	2	59
α-helix	66-71	6
β-strand	78-82	5	61
α-helix	90-103	14
β-strand	107-112	6	61
α-helix	118-122	5
β-strand	131-136	6	61
α-helix	138-140	3
β-strand	152-155	4	62
α-helix	158-168	11
α-helix	172-174	3
α-helix	176	1
β-strand	177-178	2	62
α-helix	183-188	6
α-helix	190-191	2
β-strand	195-201	7	62
β-strand	207-214	8	62

Chain F: 5 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	56-71	16
β-strand	73	1	63
β-strand	84	1	64
α-helix	85-86	2
α-helix	87-102	16
α-helix	117-127	11
β-strand	132-136	5	26
β-strand	137	1	63
α-helix	138	1
β-strand	143	1	63
β-strand	146-147	2	26
β-strand	152	1	64

Chain G: 7 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	27	1
β-strand	28	1	65
α-helix	29	1
β-strand	35	1	65
β-strand	38-49	12	26
α-helix	51-55	5
α-helix	57-61	5
α-helix	62-66	5
α-helix	67-69	3
β-strand	70	1	26
β-strand	73-74	2	26
β-strand	79-89	11	26
β-strand	105-107	3	26
α-helix	108	1
β-strand	114-125	12	26
β-strand	132-136	5	66
β-strand	140	1	66
β-strand	145-149	5	66
β-strand	153-157	5	66
β-strand	167-169	3	67
β-strand	216-218	3	67
β-strand	229-237	9	66
β-strand	244-248	5	66

Chain H: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	13
β-strand	23-30	8	13
β-strand	37-43	7	13
β-strand	54-60	7	13
α-helix	89-92	4
β-strand	95-105	11	13
β-strand	111-118	8	13
β-strand	121-128	8	13
α-helix	129-132	4
β-strand	139-145	7	13

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P07703 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P50106 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P22139
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P28000
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	70	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P40422

9 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>5N61_1 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 2 (B), FASTA

>5N61_2 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 3 (C), FASTA

>5N61_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 4 (D), FASTA

>5N61_4 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 5 (E), FASTA

>5N61_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 6 (F), FASTA

>5N61_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 7 (G), FASTA

>5N61_7 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 8 (H), FASTA

>5N61_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 9 (I), FASTA

>5N61_9 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 10 (J), FASTA

>5N61_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Sequence of entity 11 (K), FASTA

>5N61_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MTEDIEQKKTATEVTPQEPKHIQEEEEQDVDMTGDEEQEEEPDREKIKLLTQATSEDGTS
ASFQIVEEDHTLGNALRYVIMKNPDVEFCGYSIPHPSENLLNIRIQTYGETTAVDALQKG
LKDLMDLCDVVESKFTEKIKSM

Sequence of entity 12 (L), FASTA

>5N61_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MSREGFQIPTNLDAAAAGTSQARTATLKYICAECSSKLSLSRTDAVRCKDCGHRILLKAR
TKRLVQFEAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	7
MG	Magnesium ion	Mg	1

Water and common crystallization additives (SO4) are not listed.

Primary citation

Structural Basis of RNA Polymerase I Transcription Initiation. Engel, C., Gubbey, T., Neyer, S. et al. Cell (2017) 169:120-131.e22. DOI 10.1016/j.cell.2017.03.003 · PubMed

Other PDB entries of the same protein (UniProt P10964 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*

Browse structure collections

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