6RUI: DNA-directed RNA polymerase I subunit RPA12

RNA Polymerase I Pre-initiation complex DNA opening intermediate 2. Determined by electron microscopy at 2.7 Å resolution. Released 11 Dec 2019.

Method: Electron microscopy
Resolution: 2.7 Å
Organisms: synthetic construct, Saccharomyces cerevisiae
Chains: 20
Atoms: 51,525
Mol. weight: 927.89 kDa
Ligands: ZN
Released: 11 Dec 2019

Explore 6RUI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6RUI contains 273 α-helices and 307 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 79 helices, 63 β-strands

Element	Residues	Length	Sheet
β-strand	13-18	6	13
α-helix	24-27	4
α-helix	43-45	3
β-strand	77-86	10	14
α-helix	91-98	8
β-strand	101	1	15
β-strand	108	1	15
α-helix	114-124	11
α-helix	131-134	4
α-helix	175-198	24
α-helix	210-223	14
β-strand	243-245	3	16
β-strand	251-253	3	16
α-helix	262-265	4
β-strand	313-314	2	16
α-helix	315-316	2
α-helix	319-330	12
α-helix	332-338	7
α-helix	352-354	3
β-strand	356-362	7	14
α-helix	366-368	3
α-helix	369-371	3
β-strand	372-373	2	17
β-strand	376-377	2	17
α-helix	381-405	25
α-helix	418-438	21
α-helix	455-458	4
α-helix	467	1
α-helix	468-472	5
β-strand	474-476	3	18
β-strand	479-486	8	19
β-strand	494-497	4	19
α-helix	499-502	4
β-strand	506-510	5	20
α-helix	511	1
α-helix	516-525	10
β-strand	533-537	5	20
β-strand	543-545	3	20
α-helix	551-558	8
α-helix	563-565	3
β-strand	576-580	5	20
β-strand	586-591	6	19
α-helix	597-599	3
β-strand	600-607	8	19
β-strand	614-616	3	19
α-helix	618-620	3
β-strand	632-636	5	19
α-helix	641-649	9
β-strand	652	1	19
β-strand	658	1	21
β-strand	665	1	21
α-helix	674-680	7
β-strand	686-687	2	22
α-helix	689-699	11
β-strand	719	1	23
β-strand	725	1	23
β-strand	726-727	2	22
α-helix	729-739	11
β-strand	748-752	5	24
α-helix	757-760	4
β-strand	768-772	5	24
β-strand	775-778	4	24
α-helix	783-786	4
α-helix	793-800	8
α-helix	803-823	21
β-strand	826	1	25
α-helix	831-833	3
α-helix	834	1
β-strand	835	1	26
α-helix	836	1
α-helix	839-847	9
α-helix	848-850	3
α-helix	853-861	9
α-helix	873-883	11
α-helix	886-911	26
β-strand	916	1	26
α-helix	924-931	8
α-helix	937-944	8
β-strand	948-949	2	27
β-strand	952	1	28
β-strand	955	1	28
α-helix	970	1
α-helix	977-979	3
β-strand	981-982	2	27
β-strand	985	1	29
β-strand	989	1	29
α-helix	992-1009	18
α-helix	1017-1026	10
β-strand	1031-1032	2	30
β-strand	1038-1039	2	30
β-strand	1045-1047	3	30
α-helix	1050-1052	3
β-strand	1055	1	31
α-helix	1057-1059	3
α-helix	1066-1071	6
α-helix	1073-1079	7
α-helix	1083-1085	3
β-strand	1090	1	32
α-helix	1093-1107	15
α-helix	1123-1126	4
β-strand	1132	1	32
α-helix	1138-1149	12
α-helix	1164-1175	12
β-strand	1178	1	31
α-helix	1179-1180	2
α-helix	1185-1194	10
α-helix	1218-1225	8
β-strand	1237-1241	5	33
β-strand	1242	1	34
α-helix	1248-1256	9
β-strand	1261-1262	2	35
α-helix	1263-1266	4
β-strand	1267-1275	9	4
β-strand	1289-1296	8	4
α-helix	1299-1306	8
α-helix	1310-1316	7
α-helix	1317-1321	5
α-helix	1322-1337	16
α-helix	1441-1453	13
β-strand	1461-1462	2	4
β-strand	1469-1475	7	4
α-helix	1485-1493	9
β-strand	1497-1499	3	35
β-strand	1506-1508	3	33
β-strand	1513	1	36
β-strand	1516	1	36
β-strand	1518-1522	5	33
α-helix	1526-1529	4
α-helix	1530-1532	3
β-strand	1536	1	34
α-helix	1538-1540	3
β-strand	1542-1543	2	33
α-helix	1546-1552	7
α-helix	1555-1571	17
α-helix	1579-1589	11
α-helix	1600-1603	4
α-helix	1609-1615	7
α-helix	1618-1626	9
β-strand	1631-1632	2	13
α-helix	1637-1643	7
α-helix	1645-1647	3
β-strand	1654-1660	7	37

Chain B: 59 helices, 77 β-strands

Element	Residues	Length	Sheet
β-strand	13	1	38
α-helix	18-26	9
α-helix	33	1
α-helix	36-39	4
α-helix	43-50	8
α-helix	56-58	3
β-strand	71-74	4	39
β-strand	94-104	11	39
α-helix	105-107	3
β-strand	108-109	2	40
β-strand	119-120	2	40
α-helix	121	1
α-helix	123-129	7
β-strand	134-145	12	39
β-strand	150-152	3	39
β-strand	155-162	8	39
β-strand	164	1	41
α-helix	177-182	6
β-strand	194-196	3	41
β-strand	199-203	5	41
α-helix	204	1
β-strand	205-209	5	42
α-helix	210	1
β-strand	215-218	4	43
α-helix	220-223	4
β-strand	229-239	11	43
β-strand	245-253	9	43
β-strand	258-263	6	43
β-strand	268-272	5	43
α-helix	273-280	8
α-helix	285-292	8
α-helix	300-316	17
α-helix	323-333	11
α-helix	346-356	11
α-helix	367-385	19
α-helix	390-393	4
β-strand	400-403	4	42
α-helix	405-432	28
α-helix	443-450	8
α-helix	457-467	11
β-strand	485-487	3	41
α-helix	493-497	5
β-strand	502-504	3	42
α-helix	507-509	3
α-helix	522-524	3
β-strand	528	1	44
β-strand	539	1	42
β-strand	542-544	3	42
β-strand	545	1	44
β-strand	550-551	2	45
α-helix	555-557	3
α-helix	561-567	7
α-helix	570	1
β-strand	571-572	2	46
α-helix	573-575	3
β-strand	584-588	5	46
β-strand	591-596	6	46
α-helix	598-613	16
β-strand	625-629	5	46
α-helix	637-638	2
β-strand	639-643	5	46
β-strand	649-650	2	45
β-strand	651-655	5	47
β-strand	660-664	5	47
α-helix	669-671	3
β-strand	674-675	2	47
α-helix	678-680	3
α-helix	681-682	2
β-strand	688-689	2	47
α-helix	693-696	4
α-helix	707-709	3
β-strand	710	1	48
α-helix	712-721	10
α-helix	722-724	3
β-strand	725	1	49
α-helix	733-735	3
β-strand	740-744	5	50
β-strand	748	1	51
β-strand	752-753	2	38
α-helix	756-759	4
α-helix	762-764	3
β-strand	768	1	51
β-strand	769-775	7	52
β-strand	777	1	25
β-strand	786-790	5	52
α-helix	791-795	5
β-strand	801-810	10	50
β-strand	823-825	3	53
α-helix	836-838	3
β-strand	840	1	54
β-strand	846	1	54
α-helix	847	1
β-strand	851-852	2	50
β-strand	857-863	7	53
β-strand	868-873	6	53
β-strand	880-888	9	50
β-strand	900-909	10	50
β-strand	916-919	4	52
β-strand	924-931	8	52
α-helix	933-935	3
β-strand	938-939	2	55
α-helix	943-945	3
β-strand	947-949	3	52
α-helix	951-953	3
β-strand	959	1	48
α-helix	961-975	15
β-strand	979-980	2	38
α-helix	992-1003	12
β-strand	1010-1011	2	52
β-strand	1013-1014	2	55
α-helix	1020	1
β-strand	1021	1	55
α-helix	1022	1
β-strand	1026-1035	10	52
β-strand	1036	1	49
α-helix	1041-1043	3
β-strand	1045-1047	3	19
β-strand	1052	1	56
α-helix	1058	1
β-strand	1059	1	56
α-helix	1060-1061	2
β-strand	1069-1071	3	18
α-helix	1073-1081	9
α-helix	1085-1089	5
α-helix	1090-1094	5
β-strand	1098-1104	7	57
β-strand	1109	1	57
β-strand	1113-1115	3	58
β-strand	1126-1128	3	58
α-helix	1132	1
β-strand	1133-1134	2	59
β-strand	1158-1160	3	59
β-strand	1166-1168	3	59
β-strand	1173-1179	7	57
α-helix	1181-1190	10
β-strand	1194-1199	6	13

Chain C: 13 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	34-39	6
β-strand	41-47	7	60
β-strand	52-57	6	60
α-helix	61-73	13
β-strand	77-85	9	61
β-strand	87-88	2	61
α-helix	94-102	9
β-strand	106	1	62
α-helix	108-109	2
α-helix	122-125	4
β-strand	132-139	8	61
β-strand	141-142	2	63
β-strand	157-158	2	63
β-strand	161-163	3	64
α-helix	164-166	3
α-helix	167	1
β-strand	168-170	3	61
α-helix	173-176	4
β-strand	186	1	62
β-strand	192-195	4	64
β-strand	201-211	11	61
α-helix	217-219	3
β-strand	225-235	11	60
α-helix	242-248	7
β-strand	256-257	2	65
β-strand	266-267	2	65
α-helix	278-281	4
β-strand	289-302	14	60
α-helix	312-329	18
α-helix	332-333	2
β-strand	334	1	66

Chain D: 3 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	22-24	3	37
β-strand	29-30	2	67
α-helix	31-32	2
α-helix	33-46	14
α-helix	86-95	10

Chain E: 13 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	5-25	21
β-strand	28	1	68
α-helix	32-35	4
α-helix	39-46	8
β-strand	47	1	69
β-strand	53	1	69
β-strand	60-62	3	70
β-strand	64	1	68
α-helix	66-71	6
β-strand	78-81	4	70
β-strand	87-88	2	71
α-helix	90-103	14
β-strand	107-112	6	70
β-strand	115-116	2	71
α-helix	121-123	3
β-strand	131-136	6	70
α-helix	144-146	3
β-strand	152-155	4	72
α-helix	156-157	2
α-helix	158-168	11
α-helix	172-174	3
β-strand	177-178	2	72
α-helix	185-188	4
α-helix	190-191	2
α-helix	194	1
β-strand	195-202	8	72
β-strand	206-214	9	72

Chain F: 7 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	57-71	15
β-strand	73	1	37
α-helix	74-75	2
α-helix	76-78	3
β-strand	84	1	73
α-helix	89-101	13
α-helix	105-107	3
α-helix	117-124	8
β-strand	132-137	6	37
β-strand	143-147	5	37
β-strand	152	1	73
α-helix	153	1

Chain G: 6 helices, 19 β-strands

Element	Residues	Length	Sheet
α-helix	14-17	4
α-helix	18-20	3
β-strand	28	1	74
β-strand	35	1	74
β-strand	38	1	75
β-strand	39-40	2	67
β-strand	41-49	9	37
α-helix	57-61	5
α-helix	62-66	5
β-strand	73	1	75
β-strand	80	1	75
β-strand	84-89	6	37
α-helix	90-91	2
β-strand	103-107	5	37
β-strand	114-122	9	37
β-strand	125	1	75
β-strand	132-140	9	76
β-strand	144-149	6	76
β-strand	153-158	6	76
α-helix	159-161	3
β-strand	167-168	2	77
β-strand	217-218	2	77
β-strand	224	1	77
β-strand	229-238	10	76
β-strand	243-248	6	76

Chain H: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	4-16	13	23
β-strand	23-30	8	23
β-strand	37-43	7	23
β-strand	54-60	7	23
α-helix	89-91	3
β-strand	95-108	14	23
β-strand	111-118	8	23
β-strand	121-124	4	23
β-strand	140-145	6	23

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Template strand	T	DNA	70	synthetic construct
Nontemplate strand	U	DNA	70	synthetic construct
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae	P32529 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA34	N	protein	233	Saccharomyces cerevisiae	P47006 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA49	M	protein	415	Saccharomyces cerevisiae	Q01080 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae	P46669

8 more molecules are not listed.

Sequence of entity 1 (T), FASTA

>6RUI_1 Template strand (chains T)
GTCTTCAACTGCTTTCGCATGAAGTACCTCCCAACTACTTTTCCTCACACTTGTACTCCA
TGACTAAACC

Sequence of entity 2 (U), FASTA

>6RUI_2 Nontemplate strand (chains U)
GGTTTAGTCATGGAGTACAAGTGTGAGGAAAAGTAGTTGGGAGGTACTTCATGCGAAAGC
AGTTGAAGAC

Sequence of entity 3 (I), FASTA

>6RUI_3 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 4 (N), FASTA

>6RUI_4 DNA-directed RNA polymerase I subunit RPA34 (chains N)
MSKLSKDYVSDSDSDDEVISNEFSIPDGFKKCKHLKNFPLNGDNKKKAKQQQVWLIKFPS
NVDISKLKSLPVDFESSTTMTIDKHDYKIMDDTDIESSLTQDNLSNMTLLVPSESKESLK
IASTAKDNAPLQFDKVFSVSETAKIPAIDYSKVRVPRKDVPKVEGLKLEHFATGYDAEDF
HVAEEVKENKKEPKKRSHHDDEEESSEKKKKKKEKREKREKKDKKDKKKKHRD

Sequence of entity 5 (M), FASTA

>6RUI_5 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERL
EYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTR
PSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDE
ITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNS
KYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILS
RFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKV
VSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Sequence of entity 6 (A), FASTA

>6RUI_6 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 7 (B), FASTA

>6RUI_7 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 8 (C), FASTA

>6RUI_8 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 9 (D), FASTA

>6RUI_9 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 10 (E), FASTA

>6RUI_10 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 11 (F), FASTA

>6RUI_11 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 12 (G), FASTA

>6RUI_12 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

Molecular insight into RNA polymerase I promoter recognition and promoter melting. Sadian, Y., Baudin, F., Tafur, L. et al. Nat Commun (2019) 10:5543-5543. DOI 10.1038/s41467-019-13510-w · PubMed

Other PDB entries of the same protein (UniProt P32529 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9G1V 2.7 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site
4C2M 2.8 Å, Structure of RNA polymerase I at 2.8 A resolution
9G27 2.8 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, pre-translocation…
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
4C3I 3.0 Å, Structure of 14-subunit RNA polymerase I at 3.0 A resolution, crystal form C2-100
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
6HLQ 3.18 Å, Yeast RNA polymerase I* elongation complex bound to nucleotide analog GMPCPP
6HLR 3.18 Å, Yeast RNA polymerase I elongation complex bound to nucleotide analog GMPCPP (core focused)
9G2B 3.2 Å, Yeast RNA polymerase I elongation complex stalled by an apurinic site, 12-subunit
6HLS 3.21 Å, Yeast apo RNA polymerase I*
4C3H 3.27 Å, Structure of 14-subunit RNA polymerase I at 3.27 A resolution, crystal form C2-93

Browse structure collections

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