6RUO: RNA Polymerase I Open Complex conformation 1

RNA Polymerase I Open Complex conformation 1. Determined by electron microscopy at 3.5 Å resolution. Released 11 Dec 2019.

Method: Electron microscopy
Resolution: 3.5 Å
Organisms: Saccharomyces cerevisiae, synthetic construct
Chains: 20
Atoms: 50,792
Mol. weight: 928.41 kDa
Ligands: ZN
Released: 11 Dec 2019

Explore 6RUO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6RUO contains 256 α-helices and 329 β-strands across 18 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 76 helices, 66 β-strands

Element	Residues	Length	Sheet
β-strand	11-14	4	7
β-strand	18	1	8
β-strand	34	1	9
β-strand	48	1	9
β-strand	53	1	10
β-strand	55	1	10
β-strand	61	1	11
β-strand	68	1	11
β-strand	77-86	10	12
α-helix	91-98	8
β-strand	101-102	2	13
β-strand	107-108	2	13
α-helix	112-124	13
α-helix	131-138	8
α-helix	175-198	24
α-helix	210-226	17
β-strand	243-245	3	14
β-strand	251-253	3	14
α-helix	255-257	3
α-helix	262-268	7
β-strand	313-315	3	14
α-helix	317-323	7
α-helix	326-330	5
α-helix	332-339	8
α-helix	348-350	3
α-helix	352-354	3
β-strand	356-362	7	12
α-helix	369-370	2
β-strand	371-373	3	15
β-strand	376-378	3	15
α-helix	381-398	18
α-helix	400-404	5
α-helix	418-424	7
α-helix	425-427	3
α-helix	431-438	8
α-helix	452-454	3
α-helix	467-470	4
β-strand	475-476	2	16
β-strand	479-483	5	17
β-strand	486	1	18
β-strand	494-497	4	17
α-helix	501-503	3
β-strand	507-510	4	19
α-helix	511	1
α-helix	516-525	10
β-strand	533-535	3	19
β-strand	545	1	19
α-helix	551-558	8
α-helix	568-570	3
α-helix	573-575	3
β-strand	576-579	4	19
β-strand	586-590	5	17
α-helix	597-599	3
β-strand	602-607	6	17
α-helix	608	1
β-strand	615	1	17
β-strand	616	1	18
α-helix	618-621	4
β-strand	632-636	5	17
α-helix	641-649	9
β-strand	658	1	20
β-strand	665	1	20
α-helix	672-680	9
β-strand	686-687	2	21
α-helix	689-697	9
β-strand	719	1	22
β-strand	726-727	2	21
α-helix	729-737	9
β-strand	748-751	4	23
α-helix	757-760	4
β-strand	769-772	4	23
β-strand	776-778	3	23
α-helix	783-786	4
α-helix	795-798	4
α-helix	803-823	21
β-strand	826-827	2	24
α-helix	831-833	3
α-helix	834	1
β-strand	835	1	25
α-helix	836	1
α-helix	837-848	12
α-helix	853-861	9
α-helix	875-883	9
α-helix	887-911	25
β-strand	916	1	25
α-helix	926-929	4
α-helix	938-941	4
α-helix	977-979	3
α-helix	992-998	7
α-helix	1009-1012	4
α-helix	1017-1023	7
β-strand	1031-1032	2	26
β-strand	1038-1039	2	26
β-strand	1045-1047	3	26
β-strand	1055	1	27
α-helix	1066-1071	6
α-helix	1073-1076	4
α-helix	1086-1088	3
β-strand	1090	1	28
α-helix	1095-1107	13
β-strand	1132	1	28
α-helix	1140-1148	9
α-helix	1167-1176	10
β-strand	1178	1	27
α-helix	1187-1190	4
α-helix	1196-1198	3
α-helix	1218-1225	8
β-strand	1238-1239	2	29
β-strand	1241	1	30
β-strand	1242	1	31
α-helix	1248-1256	9
β-strand	1262	1	32
α-helix	1263-1265	3
β-strand	1267-1275	9	33
β-strand	1289-1296	8	33
α-helix	1302-1305	4
α-helix	1310-1315	6
α-helix	1316-1321	6
α-helix	1322-1325	4
α-helix	1327-1333	7
α-helix	1442-1453	12
β-strand	1460-1462	3	33
β-strand	1469-1475	7	33
α-helix	1486-1495	10
β-strand	1497	1	32
β-strand	1506-1508	3	34
β-strand	1513	1	35
β-strand	1516	1	35
β-strand	1518	1	30
β-strand	1520-1522	3	34
α-helix	1527-1529	3
β-strand	1536	1	31
β-strand	1542-1543	2	29
α-helix	1546-1552	7
α-helix	1555-1572	18
α-helix	1579-1589	11
α-helix	1609-1615	7
α-helix	1618-1628	11
β-strand	1632	1	7
α-helix	1637-1640	4
α-helix	1645-1647	3
β-strand	1655-1659	5	36

Chain B: 45 helices, 85 β-strands

Element	Residues	Length	Sheet
α-helix	20-26	7
α-helix	36-41	6
α-helix	43-50	8
α-helix	61-64	4
α-helix	65-67	3
β-strand	72	1	37
β-strand	96	1	37
β-strand	97-104	8	38
β-strand	108-109	2	39
β-strand	119-120	2	39
α-helix	123-129	7
β-strand	134-143	10	38
β-strand	145	1	40
β-strand	150	1	40
β-strand	155-162	8	38
α-helix	177-181	5
β-strand	196	1	41
β-strand	199	1	41
β-strand	203	1	42
β-strand	205	1	43
β-strand	206-209	4	44
β-strand	214-215	2	45
β-strand	218	1	46
α-helix	220-225	6
β-strand	229-238	10	45
β-strand	246-253	8	45
β-strand	258-262	5	45
β-strand	269-272	4	45
α-helix	273-280	8
α-helix	285-292	8
α-helix	307-316	10
α-helix	323-334	12
α-helix	346-356	11
α-helix	367-370	4
α-helix	378-381	4
α-helix	390-393	4
β-strand	400-403	4	44
α-helix	405-423	19
α-helix	425-432	8
α-helix	443-449	7
α-helix	457-466	10
β-strand	485	1	42
α-helix	494-498	5
β-strand	502	1	47
β-strand	503	1	43
α-helix	508-510	3
β-strand	528	1	48
β-strand	544	1	47
β-strand	545	1	48
β-strand	551-552	2	49
α-helix	562-565	4
β-strand	571	1	50
β-strand	584-588	5	50
β-strand	592-596	5	50
α-helix	598-612	15
β-strand	625-628	4	50
α-helix	637-638	2
β-strand	640-643	4	50
β-strand	648-649	2	49
β-strand	651-655	5	51
β-strand	661-664	4	51
α-helix	666-669	4
β-strand	674-675	2	51
α-helix	678-680	3
β-strand	688-689	2	51
α-helix	693-696	4
α-helix	712-718	7
β-strand	725	1	52
α-helix	733-735	3
β-strand	741-744	4	53
β-strand	748	1	54
β-strand	753	1	55
α-helix	762-764	3
β-strand	769-775	7	56
β-strand	776-777	2	24
β-strand	787	1	57
β-strand	788-789	2	56
β-strand	790	1	58
α-helix	791-794	4
β-strand	801-810	10	53
β-strand	824-826	3	59
β-strand	840	1	60
β-strand	846	1	60
α-helix	847	1
β-strand	852	1	61
β-strand	857-859	3	62
β-strand	861-862	2	59
β-strand	869	1	59
β-strand	872-873	2	62
β-strand	880	1	61
β-strand	885-888	4	53
α-helix	897-898	2
β-strand	900-909	10	53
β-strand	917	1	63
β-strand	919	1	56
β-strand	925	1	63
β-strand	927	1	57
β-strand	931	1	58
α-helix	933-935	3
β-strand	947-949	3	56
α-helix	951-953	3
α-helix	960-975	16
β-strand	980	1	55
α-helix	992-1003	12
β-strand	1010-1011	2	56
β-strand	1014	1	64
β-strand	1021	1	64
α-helix	1022	1
α-helix	1025	1
β-strand	1026-1033	8	56
β-strand	1036	1	52
β-strand	1045	1	17
α-helix	1067-1068	2
β-strand	1069-1070	2	16
α-helix	1073-1082	10
α-helix	1089	1
α-helix	1090-1094	5
β-strand	1098-1099	2	65
β-strand	1102-1104	3	66
β-strand	1109	1	66
β-strand	1113-1115	3	67
β-strand	1126-1128	3	67
β-strand	1133-1134	2	68
β-strand	1158-1159	2	68
β-strand	1167-1168	2	68
β-strand	1173-1175	3	66
β-strand	1178-1179	2	65
α-helix	1180-1192	13
β-strand	1194	1	8
β-strand	1198-1200	3	7

Chain C: 12 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	41	1	69
β-strand	44-47	4	69
β-strand	52-57	6	69
α-helix	63-69	7
α-helix	70-74	5
β-strand	76-88	13	70
α-helix	94-102	9
β-strand	106-107	2	71
α-helix	122-125	4
β-strand	133-139	7	70
β-strand	141-142	2	72
α-helix	153-156	4
β-strand	157-158	2	72
β-strand	161-163	3	73
β-strand	168-170	3	70
β-strand	185-186	2	71
β-strand	192-195	4	73
β-strand	201-212	12	70
α-helix	217-219	3
β-strand	225-235	11	69
α-helix	242-245	4
α-helix	253-255	3
β-strand	256	1	74
β-strand	267	1	74
α-helix	270-272	3
α-helix	279-281	3
β-strand	289-302	14	69
α-helix	310-313	4
α-helix	322-329	8
β-strand	334	1	75

Chain D: 3 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	8-11	4
β-strand	29-30	2	76
α-helix	33-46	14
α-helix	83-95	13

Chain E: 12 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	4-7	4
α-helix	10-26	17
β-strand	28-29	2	77
α-helix	32-35	4
α-helix	39-45	7
β-strand	47	1	78
β-strand	53	1	78
β-strand	60-62	3	79
β-strand	63-64	2	77
α-helix	67-70	4
β-strand	78-80	3	79
β-strand	81	1	80
β-strand	87-88	2	81
α-helix	93-103	11
β-strand	107	1	79
β-strand	108-112	5	80
β-strand	115-116	2	81
β-strand	132-136	5	80
α-helix	138-140	3
α-helix	144-146	3
α-helix	151	1
β-strand	152-155	4	82
α-helix	162-167	6
α-helix	176	1
β-strand	177-178	2	83
α-helix	183-187	5
β-strand	196-202	7	82
β-strand	206-212	7	82
β-strand	213-214	2	83

Chain F: 4 helices, 5 β-strands

Element	Residues	Length	Sheet
α-helix	59-71	13
β-strand	73-74	2	36
β-strand	84	1	84
α-helix	89-101	13
α-helix	117-124	8
α-helix	125-127	3
β-strand	132-137	6	36
β-strand	143-147	5	36
β-strand	152	1	84

Chain G: 3 helices, 16 β-strands

Element	Residues	Length	Sheet
α-helix	14-20	7
β-strand	38-44	7	76
β-strand	49	1	36
α-helix	57-65	9
β-strand	73-74	2	76
β-strand	79-89	11	76
β-strand	104-107	4	36
β-strand	114-115	2	36
β-strand	118-125	8	76
β-strand	132-140	9	85
β-strand	144-149	6	85
β-strand	153-158	6	85
α-helix	159-161	3
β-strand	168	1	86
β-strand	217	1	86
β-strand	228-233	6	85
β-strand	237	1	87
β-strand	244	1	87
β-strand	246-248	3	85

Chain H: 0 helices, 15 β-strands

Element	Residues	Length	Sheet
β-strand	4-6	3	88
β-strand	10-16	7	89
β-strand	23-30	8	89
β-strand	37-43	7	89
β-strand	54	1	89
β-strand	57-58	2	22
β-strand	59-60	2	88
β-strand	95-99	5	22
β-strand	100	1	90
β-strand	106	1	91
β-strand	112	1	91
β-strand	116-117	2	90
β-strand	122-123	2	90
β-strand	127	1	91
β-strand	140-144	5	22

10 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RNA polymerase I-specific transcription initiation factor RRN7	Q	protein	514	Saccharomyces cerevisiae	P40992 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA49	M	protein	415	Saccharomyces cerevisiae	Q01080 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA190	A	protein	1664	Saccharomyces cerevisiae	P10964 (AlphaFold model)
DNA-directed RNA polymerase I subunit RPA135	B	protein	1203	Saccharomyces cerevisiae	P22138 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	335	Saccharomyces cerevisiae	P07703
DNA-directed RNA polymerase I subunit RPA14	D	protein	137	Saccharomyces cerevisiae	P50106
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	215	Saccharomyces cerevisiae	P20434
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	155	Saccharomyces cerevisiae	P20435
DNA-directed RNA polymerase I subunit RPA43	G	protein	326	Saccharomyces cerevisiae	P46669
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	146	Saccharomyces cerevisiae	P20436
DNA-directed RNA polymerase I subunit RPA12	I	protein	125	Saccharomyces cerevisiae	P32529
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	70	Saccharomyces cerevisiae	P22139

8 more molecules are not listed.

Sequence of entity 1 (Q), FASTA

>6RUO_1 RNA polymerase I-specific transcription initiation factor RRN7 (chains Q)
MSTFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDEDDLNGLGAGVITRRL
NLTTNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKLLFLKSFQFILKRQIRWLI
TEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTSTISILYLASTHLSLPVYTCD
YIKWICTAKMPYFQASEILPKSWRIQLPNYYVSILEGSISPFNGQLYNKIALTCGMIHFK
EFFNSEISCQGLLLKLVMQCALPPEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSN
HAELRVLSYFMLTINWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGRNIVKVVYPDK
PTSSDYFQWSEEETLEFLKWMEKQFLPTQTKSLHNENGSMEMTIDQKIARRKLYKIFPLD
REANHDGEFNDSTHQLTFIEDLQERYAKQTPFFESNKIRDSLNYQEANPPARKEAIGRLL
THIASQLLVDFAISKEQLKDCISRIKNACLHRMN

Sequence of entity 2 (M), FASTA

>6RUO_2 DNA-directed RNA polymerase I subunit RPA49 (chains M)
MSVKRSVSEIEIESVQDQPSVAVGSFFKGFRAPSDTTFDLYKKKKSEKDEFVLHGENERL
EYEGYTDSSSQASNQYVVGLFNPEKKSIQLYKAPVLVSKVVSKSSKNLRGPKIKSKSDTR
PSALRNALGEAFGTKKAKKAIADLERNRIDSDKLTDSAIDIVDSVRTASKDLPTRAQLDE
ITSNDRPTPLANIDATDVEQIYPIESIIPKKELQFIRVSSILKEADKEKKLELFPYQNNS
KYVAKKLDSLTQPSQMTKLQLLYYLSLLLGVYENRRVNNKTKLLERLNSPPEILVDGILS
RFTVIKPGQFGRSKDRSYFIDPQNEDKILCYILAIIMHLDNFIVEITPLAHELNLKPSKV
VSLFRVLGAIVKGATVAQAEAFGIPKSTAASYKIATMKVPFKLPEMTRRGRGPRR

Sequence of entity 3 (A), FASTA

>6RUO_3 DNA-directed RNA polymerase I subunit RPA190 (chains A)
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRN
LCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYAC
KLRLLQYGLIDESYKLDEITLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNE
LKSKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFS
PKFRKDGFTKIFETALNEKQITNNRVKGFIRQDMIKKQKQAKKLDGSNEASANDEESFDV
GRNPTTRPKTGSTYILSTEVKNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVL
VVPPTRFRLPSKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAA
RSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNED
GSLVSLIGMSVEQRKALANQLLTPSSNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASM
MGHKVRVLPNEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTP
TSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVLFKDGALLCGI
LDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNYITATAFTCGMDDLRLTAEGN
KWRTDILKTSVDTGREAAAEVTNLDKDTPADDPELLKRLQEILRDNNKSGILDAVTSSKV
NAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVM
VSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCLDNYYALLKKY
NPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGSVSENF
QDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM
TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISK
VLLSEVIDKVIVTETTGTSNTAGGNAARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQ
FIHLLEAAIVKEIKKQKRTTGPDIGVAVPRLQTDVANSSSNSKRLEEDNDEEQSHKKTKQ
AVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKSIVEANNNMN
KVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRKSIIRQ
IPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN
TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQ
FLTKAVLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKVPNAA

Sequence of entity 4 (B), FASTA

>6RUO_4 DNA-directed RNA polymerase I subunit RPA135 (chains B)
MSKVIKPPGQARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSEDEISNSGYLGNKLSVSVEQVSIAKPMSNDGVSSAVERK
VYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVMLQSNRCHLNKMSPYEL
VQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPMAIIRPSFANRGASYSHYGIQIRSVR
PDQTSQTNVLHYLNDGQVTFRFSWRKNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDS
FLTDRLELLLRGFKKRYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLV
HLGKDGSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKEKIDEY
LQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFLSTGNLVSQSGLDLQQ
VSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCG
LLNHFAHKCRISTQQSDVSRIPSILYSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQ
GKIIADTLRYWKVEGKTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDK
EDIVGPFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRNMYQCQ
MGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNFPNGFNAVVAVISYTG
YDMDDAMIINKSADERGFGYGTMYKTEKVDLALNRNRGDPITQHFGFGNDEWPKEWLEKL
DEDGLPYIGTYVEEGDPICAYFDDTLNKTKIKTYHSSEPAYIEEVNLIGDESNKFQELQT
VSIKYRIRRTPQIGDKFSSRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTI
GMFVESLAGKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGATGE
ELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGGIRVGEMERDALI
GHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVPRIGSISTVCCRRCSMRFEDAKK
LLTKSEDGEKIFIDDSQIWEDGQGNKFVGGNETTTVAIPFVLKYLDSELSAMGIRLRYNV
EPK

Sequence of entity 5 (C), FASTA

>6RUO_5 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MSNIVGIEYNRVTNTTSTDFPGFSKDAENEWNVEKFKKDFEVNISSLDAREANFDLINID
TSIANAFRRIMISEVPSVAAEYVYFFNNTSVIQDEVLAHRIGLVPLKVDPDMLTWVDSNL
PDDEKFTDENTIVLSLNVKCTRNPDAPKGSTDPKELYNNAHVYARDLKFEPQGRQSTTFA
DCPVVPADPDILLAKLRPGQEISLKAHCILGIGGDHAKFSPVSTASYRLLPQINILQPIK
GESARRFQKCFPPGVIGIDEGSDEAYVKDARKDTVSREVLRYEEFADKVKLGRVRNHFIF
NVESAGAMTPEEIFFKSVRILKNKAEYLKNCPITQ

Sequence of entity 6 (D), FASTA

>6RUO_6 DNA-directed RNA polymerase I subunit RPA14 (chains D)
MMKGSRRTGNNTATTLNTPVVIHATQLPQHVSTDEVLQFLESFIDEKENIIDSTTMNTIS
GNAADADAAAVANTSLNIDTNLSSSISQLKRIQRDFKGLPPAQDFSAAPIQVSTTEKKET
SIGVSATGGKKTTFADE

Sequence of entity 7 (E), FASTA

>6RUO_7 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSF
QANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSA
MKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQR
ADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM

Sequence of entity 8 (F), FASTA

>6RUO_8 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDYEEAFNDGNENFEDFDVEHFSDEETYEEKPQFKDGETTDANGKTIVTGGNGPEDFQQ
HEQIRRKTLKEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRI
AMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL

Sequence of entity 9 (G), FASTA

>6RUO_9 DNA-directed RNA polymerase I subunit RPA43 (chains G)
MSQVKRANENRETARFIKKHKKQVTNPIDEKNGTSNCIVRVPIALYVSLAPMYLENPLQG
VMKQHLNPLVMKYNNKVGGVVLGYEGLKILDADPLSKEDTSEKLIKITPDTPFGFTWCHV
NLYVWQPQVGDVLEGYIFIQSASHIGLLIHDAFNASIKKNNIPVDWTFVHNDVEEDADVI
NTDENNGNNNNEDNKDSNGGSNSLGKFSFGNRSLGHWVDSNGEPIDGKLRFTVRNVHTTG
RVVSVDGTLISDADEEGNGYNSSRSQAESLPIVSNKKIVFDDEVSIENKESHKELDLPEV
KEDNGSEIVYEENTSESNDGESSDSD

Sequence of entity 10 (H), FASTA

>6RUO_10 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSNTLFDDIFQVSEVDPGRYNKVCRIEAASTTQDQCKLTLDINVELFPVAAQDSLTVTIA
SSLNLEDTPANDSSATRSWRPPQAGDRSLADDYDYVMYGTAYKFEEVSKDLIAVYYSFGG
LLMRLEGNYRNLNNLKQENAYLLIRR

Sequence of entity 11 (I), FASTA

>6RUO_11 DNA-directed RNA polymerase I subunit RPA12 (chains I)
MSVVGSLIFCLDCGDLLENPNAVLGSNVECSQCKAIYPKSQFSNLKVVTTTADDAFPSSL
RAKKSVVKTSLKKNELKDGATIKEKCPQCGNEEMNYHTLQLRSADEGATVFYTCTSCGYK
FRTNN

Sequence of entity 12 (J), FASTA

>6RUO_12 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIVPVRCFSCGKVVGDKWESYLNLLQEDELDEGTALSRLGLKRYCCRRMILTHVDLIEKF
LRYNPLEKRD

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	8

Primary citation

Molecular insight into RNA polymerase I promoter recognition and promoter melting. Sadian, Y., Baudin, F., Tafur, L. et al. Nat Commun (2019) 10:5543-5543. DOI 10.1038/s41467-019-13510-w · PubMed

Other PDB entries of the same protein (UniProt P40992 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6RUI 2.7 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 2
6RQL 2.9 Å, RNA Polymerase I Closed Conformation 2 (CC2)
6RWE 3.0 Å, RNA Polymerase I Open Complex conformation 2
6RRD 3.1 Å, RNA Polymerase I Pre-initiation complex DNA opening intermediate 1
5O7X 3.2 Å, Crystal structure of S. Cerevisiae core factor at 3.2A resolution
5N61 3.4 Å, RNA polymerase I initially transcribing complex
6TPS 3.54 Å, early intermediate RNA Polymerase I Pre-initiation complex - eiPIC
6RQH 3.7 Å, RNA Polymerase I Closed Conformation 1 (CC1)
5W5Y 3.8 Å, RNA polymerase I Initial Transcribing Complex
5W66 3.9 Å, RNA polymerase I Initial Transcribing Complex State 3
5W64 4.2 Å, RNA Polymerase I Initial Transcribing Complex State 1
5W65 4.3 Å, RNA polymerase I Initial Transcribing Complex State 2

Browse structure collections

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