6X8O: BimBH3 peptide tetramer

BimBH3 peptide tetramer. Determined by X-ray diffraction at 1.31 Å resolution. Released 9 Sept 2020.

Method: X-ray diffraction
Resolution: 1.31 Å
Organism: Homo sapiens
Chains: 4
Atoms: 1,197
Mol. weight: 13.15 kDa
Ligands: SCN
Released: 9 Sept 2020

Explore 6X8O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6X8O contains 4 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	144-165	22

Chains B and D: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	146-165	20

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bcl-2-like protein 11	A, B, C, D	protein	27	Homo sapiens	O43521 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>6X8O_1 Bcl-2-like protein 11 (chains A, B, C, D)
DMRPEIWIAQELRRIGDEFNAYYARRX

Ligands and cofactors

ID	Name	Formula	Copies
SCN	Thiocyanate ion	C N S	1

Primary citation

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association. Assafa, T.E., Nandi, S., Smilowicz, D. et al. Structure (2021) 29:114-124.e3. DOI 10.1016/j.str.2020.09.002 · PubMed

Other PDB entries of the same protein (UniProt O43521 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2WH6 1.5 Å, Crystal structure of anti-apoptotic BHRF1 in complex with the Bim BH3 domain
4QVF 1.53 Å, Crystal structure of Bcl-xL in complex with BIM BH3 domain
4A1U 1.54 Å, Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL
2NL9 1.55 Å, Crystal structure of the Mcl-1:Bim BH3 complex
6UA3 1.55 Å, Human Mcl-1 in complex with a modified Bim BH3 peptide
5VWY 1.55 Å, Bak core latch dimer in complex with Bim-h3Pc-RT
5VX0 1.6 Å, Bak in complex with Bim-h3Glg
5VWZ 1.62 Å, Bak in complex with Bim-h3Pc
3KJ0 1.7 Å, Mcl-1 in complex with Bim BH3 mutant I2dY
3FDL 1.78 Å, Bim BH3 peptide in complex with Bcl-xL
4ZIE 1.8 Å, Crystal Structure of core/latch dimer of Bax in complex with BimBH3
2YQ6 1.8 Å, Structure of Bcl-xL bound to BimSAHB

Browse structure collections

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