6YCX: Myosin-A

Plasmodium falciparum Myosin A full-length, pre-powerstroke state. Determined by X-ray diffraction at 3.99 Å resolution. Released 11 Nov 2020.

Method: X-ray diffraction
Resolution: 3.99 Å
Organisms: Plasmodium falciparum (isolate 3D7), Plasmodium falciparum (isolate NF54)
Chains: 6
Atoms: 17,452
Mol. weight: 264.5 kDa
Ligands: MG, VO4, ADP
Released: 11 Nov 2020

Explore 6YCX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6YCX contains 112 α-helices and 78 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 42 helices, 30 β-strands

Element	Residues	Length	Sheet
α-helix	5-13	9
α-helix	29-31	3
β-strand	34-38	5	1
α-helix	42-46	5
β-strand	53-57	5	1
β-strand	66-72	7	1
β-strand	80-82	3	1
α-helix	84-86	3
β-strand	88-89	2	1
β-strand	101	1	2
α-helix	102-104	3
α-helix	110-122	13
β-strand	127-130	4	2
β-strand	133-137	5	2
α-helix	148-156	9
α-helix	164	1
α-helix	167-178	12
β-strand	185-190	6	2
α-helix	197-209	13
α-helix	218-235	18
β-strand	236-237	2	3
β-strand	245-246	2	3
β-strand	249-256	8	2
β-strand	262-265	4	2
β-strand	268-270	3	2
α-helix	275-278	4
β-strand	287	1	3
α-helix	288-296	9
α-helix	301-304	4
α-helix	310-312	3
α-helix	328-341	14
α-helix	346-364	19
β-strand	367-368	2	4
β-strand	378	1	5
β-strand	380-381	2	4
α-helix	386-395	10
α-helix	400-408	9
β-strand	411-413	3	6
β-strand	418-420	3	6
β-strand	424	1	5
α-helix	425-455	31
α-helix	457	1
β-strand	465-469	5	2
β-strand	479	1	7
α-helix	481-498	18
α-helix	499-504	6
α-helix	505-512	8
α-helix	517-520	4
α-helix	525-532	8
α-helix	538-547	10
α-helix	553-563	11
β-strand	570-572	3	7
β-strand	580-585	6	7
β-strand	588-593	6	7
α-helix	597-602	6
α-helix	607-614	8
α-helix	619-622	4
α-helix	623-625	3
α-helix	635-636	2
α-helix	641-657	17
β-strand	660-667	8	2
α-helix	680-689	10
α-helix	694-699	6
β-strand	705-708	4	8
α-helix	709-715	7
α-helix	717-719	3
α-helix	721-724	4
α-helix	731-741	11
β-strand	749-751	3	8
β-strand	755-758	4	8
α-helix	760-798	39
α-helix	801-817	17

Chain B: 40 helices, 32 β-strands

Element	Residues	Length	Sheet
α-helix	5-13	9
β-strand	24	1	9
β-strand	30	1	9
β-strand	35-38	4	10
α-helix	42-46	5
β-strand	53-57	5	10
β-strand	67-72	6	10
β-strand	80-81	2	10
α-helix	84-86	3
β-strand	88-89	2	10
β-strand	101	1	11
α-helix	102-104	3
α-helix	110-122	13
β-strand	127-130	4	11
β-strand	133-137	5	11
α-helix	148-156	9
α-helix	164	1
α-helix	167-178	12
β-strand	185-190	6	11
α-helix	197-209	13
α-helix	218-235	18
β-strand	236-237	2	12
β-strand	245-246	2	12
β-strand	249-256	8	11
β-strand	262-265	4	11
β-strand	268-270	3	11
α-helix	275-278	4
β-strand	287	1	12
α-helix	288-296	9
α-helix	301-304	4
α-helix	310-312	3
α-helix	328-341	14
α-helix	346-364	19
β-strand	367-368	2	13
β-strand	378	1	14
β-strand	380-381	2	13
α-helix	386-395	10
α-helix	400-408	9
β-strand	411-413	3	15
β-strand	418-420	3	15
β-strand	424	1	14
α-helix	425-455	31
α-helix	457	1
β-strand	465-469	5	11
β-strand	479	1	16
α-helix	481-498	18
α-helix	499-504	6
α-helix	505-512	8
α-helix	517-520	4
α-helix	525-532	8
α-helix	538-547	10
α-helix	553-563	11
β-strand	570-572	3	16
β-strand	580-585	6	16
β-strand	588-593	6	16
α-helix	597-602	6
α-helix	607-614	8
α-helix	619-622	4
α-helix	623-625	3
α-helix	635-636	2
α-helix	641-657	17
β-strand	660-667	8	11
α-helix	680-689	10
α-helix	694-699	6
β-strand	703-708	6	17
α-helix	709-715	7
α-helix	721-724	4
α-helix	731-742	12
β-strand	749-750	2	17
β-strand	755-759	5	17
α-helix	760-798	39
α-helix	801-817	17

Chain D: 9 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	74-83	10
β-strand	90-91	2	18
α-helix	92-102	11
α-helix	108-118	11
β-strand	121-122	2	18
α-helix	124-131	8
α-helix	141-144	4
α-helix	146-151	6
β-strand	158-160	3	19
α-helix	161-170	10
α-helix	177-185	9
β-strand	192-194	3	19
α-helix	195-203	9

Chain F: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	5-17	13
β-strand	22-23	2	20
α-helix	25-33	9
α-helix	41-44	4
β-strand	51-52	2	20
α-helix	53-62	10
α-helix	71-74	4
β-strand	85	1	21
α-helix	87-96	10
α-helix	103-113	11
β-strand	121	1	21
α-helix	123-133	11

Chain G: 6 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	5-16	12
β-strand	22-23	2	22
α-helix	25-33	9
β-strand	51-52	2	22
α-helix	53-63	11
β-strand	85-86	2	23
α-helix	87-97	11
α-helix	105-110	6
β-strand	120-121	2	23
α-helix	123-133	11

Chain H: 7 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	74-83	10
β-strand	90-91	2	24
α-helix	92-102	11
α-helix	108-118	11
β-strand	121-122	2	24
α-helix	124-133	10
β-strand	158-160	3	25
α-helix	161-170	10
α-helix	177-187	11
β-strand	192-194	3	25
α-helix	195-203	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Myosin-A	A, B	protein	818	Plasmodium falciparum (isolate 3D7)	Q8IDR3 (AlphaFold model)
Myosin A tail domain interacting protein	D, H	protein	204	Plasmodium falciparum (isolate NF54)	Q8I4W8 (AlphaFold model)
Uncharacterized protein	F	protein	134	Plasmodium falciparum (isolate NF54)	Q8IJM4 (AlphaFold model)
Uncharacterized protein	G	protein	134	Plasmodium falciparum (isolate NF54)	Q8IJM4 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>6YCX_1 Myosin-A (chains A, B)
MAVTNEEIKTASKIVRRVSNVEAFDKSGSVFKGYQIWTDISPTIENDPNIMFVKCVVQQG
SKKEKLTVVQIDPPGTGTPYDIDPTHAWNCNSQVDPMSFGDIGLLNHTNIPCVLDFLKHR
YLKNQIYTTAVPLIVAINPYKDLGNTTNEWIRRYRDTADHTKLPPHVFTCAREALSNLHG
VNKSQTIIVSGESGAGKTEATKQIMRYFASSKSGNMDLRIQTAIMAANPVLEAFGNAKTI
RNNNSSRFGRFMQLVISHEGGIRYGSVVAFLLEKSRIITQDDNERSYHIFYQFLKGANST
MKSKFGLKGVTEYKLLNPNSTEVSGVDDVKDFEEVIESLKNMELSESDIEVIFSIVAGIL
TLGNVRLIEKQEAGLSDAAAIMDEDMGVFNKACELMYLDPELIKREILIKVTVAGGTKIE
GRWNKNDAEVLKSSLCKAMYEKLFLWIIRHLNSRIEPEGGFKTFMGMLDIFGFEVFKNNS
LEQLFINITNEMLQKNFVDIVFERESKLYKDEGISTAELKYTSNKEVINVLCEKGKSVLS
YLEDQCLAPGGTDEKFVSSCATNLKENNKFTPAKVASNKNFIIQHTIGPIQYCAESFLLK
NKDVLRGDLVEVIKDSPNPIVQQLFEGQVIEKGKIAKGSLIGSQFLNQLTSLMNLINSTE
PHFIRCIKPNENKKPLEWCEPKILIQLHALSILEALVLRQLGYSYRRTFEEFLYQYKFVD
IAAAEDSSVENQNKCVNILKLSGLSESMYKIGKSMVFLKQEGAKILTKIQREKLVEWENC
VSVIEAAILKHKYKQKVNKNIPSLLRVQAHIRKKMVAQ

Sequence of entity 2 (D, H), FASTA

>6YCX_2 Myosin A tail domain interacting protein (chains D, H)
MKQECNVCYFNLPDPESTLGPYDNELNYFTWGPGFEYEPEPQRKPLSIEESFENSEESEE
SVADIQQLEEKVDESDVRIYFNEKSSGGKISIDNASYNARKLGLAPSSIDEKKIKELYGD
NLTYEQYLEYLSICVHDKDNVEELIKMFAHFDNNCTGYLTKSQMKNILTTWGDALTDQEA
IDALNAFSSEDNIDYKLFCEDILQ

Sequence of entity 3 (F), FASTA

>6YCX_3 Uncharacterized protein (chains F)
MASDMEEKFREAFILFSSCSDHIEMYKFFELMNSFGIILTNDEKAALPNDINMDYWLNFA
KKHYNYEQPFKHINNVNEQNTNVQIKIDNFLGIMKALDTRLTESDLNILLQITNPENKTT
LNLKTVSQKLTESI

Sequence of entity 4 (G), FASTA

>6YCX_4 Uncharacterized protein (chains G)
MASDMEEKFREAFILFSSCSDHIEMYKFFELMNSFGIILTNDEKAALPNDINMDYWLNFA
KKHYNYEQPFKHINNVNEQNTNVQIKIDNFLGIMKALDTRLTESDLNILLQITNPENKST
LNLKTVSQKLTESI

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	2
VO4	Vanadate ion	O4 V	2
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	2

Primary citation

Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets. Moussaoui, D., Robblee, J.P., Auguin, D. et al. Elife (2020) 9. DOI 10.7554/eLife.60581 · PubMed

Other PDB entries of the same protein (UniProt Q8IDR3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4MZJ 1.47 Å, Crystal Structure of MTIP from Plasmodium falciparum in complex with pGly[801,805], a…
4MZK 1.82 Å, Crystal Structure of MTIP from Plasmodium falciparum in complex with pGly[807,811], a…
4AOM 1.94 Å, MTIP and MyoA complex
4R1E 1.98 Å, Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment…
4MZL 2.01 Å, Crystal Structure of MTIP from Plasmodium falciparum in complex with HBS myoA, a…
8A12 2.03 Å, Plasmodium falciparum Myosin A full-length, post-rigor state complexed to Mg.ATP-gamma-S
8CDQ 2.21 Å, Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor…
8CDM 2.35 Å, Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor…
9T7I 2.35 Å, Plasmodium falciparum Myosin A full-length, post-rigor state, complexed to the inhibitor…
6ZN3 2.51 Å, Plasmodium facliparum glideosome trimeric sub-complex
6YCY 2.55 Å, Plasmodium falciparum Myosin A full-length, post-rigor state
6I7D 2.82 Å, Plasmodium falciparum Myosin A, post-rigor and rigor-like states

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