6ZBI: Ternary complex of Calmodulin

Ternary complex of Calmodulin bound to 2 molecules of NHE1. Determined by solution NMR. Released 17 Mar 2021.

Method: Solution NMR
Organism: Homo sapiens
Chains: 3
Atoms: 1,788
Mol. weight: 25.69 kDa
Ligands: CA
Released: 17 Mar 2021

Explore 6ZBI in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6ZBI contains 11 α-helices and 4 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	6-19	14
β-strand	27	1	1
α-helix	29-38	10
α-helix	45-55	11
β-strand	63	1	1
α-helix	65-71	7
α-helix	81-92	12
β-strand	100	1	2
α-helix	102-110	9
α-helix	118-128	11
β-strand	136	1	2
α-helix	138-145	8

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	625-648	24
α-helix	649-653	5

Chain C: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	825-853	29

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Calmodulin-1	A	protein	148	Homo sapiens	P0DP23 (AlphaFold model)
Sodium/hydrogen exchanger 1	B, C	protein	36	Homo sapiens	P19634 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6ZBI_1 Calmodulin-1 (chains A)
ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN
GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE
VDEMIREADIDGDGQVNYEEFVQMMTAK

Sequence of entity 2 (B, C), FASTA

>6ZBI_2 Sodium/hydrogen exchanger 1 (chains B, C)
ALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVAD

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	4

Primary citation

Dynamic Na + /H + exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca 2+ -dependent NHE1 activation. Sjogaard-Frich, L.M., Prestel, A., Pedersen, E.S. et al. Elife (2021) 10. DOI 10.7554/eLife.60889 · PubMed

Other PDB entries of the same protein (UniProt P0DP23 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9MXD 1.17 Å, Human E104A calmodulin:MLCK RM20 complex
7BF1 1.24 Å, Ca2+-Calmodulin in complex with peptide from brain-type creatine kinase in extended 1:2…
6XXX 1.25 Å, 1.25 Angstrom crystal structure of Ca/CaM A102V:RyR2 peptide complex
4DJC 1.35 Å, 1.35 A crystal structure of the NaV1.5 DIII-IV-Ca/CaM complex
7BF2 1.43 Å, Ca2+-Calmodulin in complex with human muscle form creatine kinase peptide in extended…
2F3Y 1.45 Å, Calmodulin/IQ domain complex
2W73 1.45 Å, High-resolution structure of the complex between calmodulin and a peptide from…
4LZX 1.5 Å, Complex of IQCG and Ca2+-free CaM
5V03 1.58 Å, A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole…
9MVW 1.58 Å, Crystal structure of S101F calmodulin - CaM:RM20 analog complex
2F3Z 1.6 Å, Calmodulin/IQ-AA domain complex
6M7H 1.6 Å, Structure of calmodulin with KN93

Browse structure collections

About this viewer

MolViewer shows 6ZBI directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.