7CRE: HnRNPK KH3 domain

hnRNPK KH3 domain in complex with a ssDNA fragment from the SIRLOIN element. Determined by X-ray diffraction at 3.0 Å resolution. Released 15 Dec 2021.

Method: X-ray diffraction
Resolution: 3.0 Å
Organisms: Homo sapiens, synthetic construct
Chains: 2
Atoms: 717
Mol. weight: 12.98 kDa
Released: 15 Dec 2021

Explore 7CRE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7CRE contains 5 α-helices and 5 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	387	1	1
β-strand	392-395	4	2
α-helix	396-398	3
α-helix	399-403	5
α-helix	405-407	3
α-helix	408-417	10
β-strand	423	1	2
β-strand	432-435	4	2
β-strand	440	1	1
α-helix	441-450	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Heterogeneous nuclear ribonucleoprotein K	A	protein	76	Homo sapiens	P61978 (AlphaFold model)
ssDNA fragment	C	DNA	16	synthetic construct

Sequence of entity 1 (A), FASTA

>7CRE_1 Heterogeneous nuclear ribonucleoprotein K (chains A)
DLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQ
DQIQNAQYLLQNSVKQ

Sequence of entity 2 (C), FASTA

>7CRE_2 ssDNA fragment (chains C)
CTCAGCCTCCCGACTC

Primary citation

Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN. Yao, J., Tu, Y., Shen, C. et al. Cell Mol Life Sci (2021) 78:7617-7633. DOI 10.1007/s00018-021-03992-7 · PubMed

Other PDB entries of the same protein (UniProt P61978 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1ZZK 0.95 Å, Crystal Structure of the third KH domain of hnRNP K at 0.95A resolution
7RJO 1.38 Å, Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with hnRNPK
1ZZI 1.8 Å, Crystal Structure Analysis of the third KH domain of hnRNP K in complex with ssDNA
7RJK 1.85 Å, Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with hnRNPK
1ZZJ 2.3 Å, Structure of the third KH domain of hnRNP K in complex with 15-mer ssDNA
7CRU 2.8 Å, hnRNPK NLS in complex with Importin alpha 1 (KPNA2)
1J5K Complex of the KH3 domain of hnrnp K with a single_stranded 10MER DNA oligonucleotide
1KHM C-terminal kh domain of hnrnp K (KH3)

Browse structure collections

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