Crystal structure of actin capping protein in complex with twinflin-1/CD2AP CPI chimera peptide (CDN-TWC). Determined by X-ray diffraction at 1.95 Å resolution. Released 3 Mar 2021.
Explore 7DS8 in 3D Show helices and sheets RCSB PDB PDBe
7DS8 contains 28 α-helices and 21 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 4-6 | 3 | |
| α-helix | 7-9 | 3 | |
| α-helix | 10-22 | 13 | |
| α-helix | 24-25 | 2 | |
| α-helix | 29-40 | 12 | |
| α-helix | 43-49 | 7 | |
| α-helix | 51-61 | 11 | |
| β-strand | 64-65 | 2 | 1 |
| α-helix | 66-67 | 2 | |
| β-strand | 74-75 | 2 | 1 |
| α-helix | 78-80 | 3 | |
| β-strand | 81-83 | 3 | 2 |
| β-strand | 86-89 | 4 | 2 |
| β-strand | 94-99 | 6 | 2 |
| β-strand | 104-110 | 7 | 2 |
| α-helix | 118-135 | 18 | |
| β-strand | 140-148 | 9 | 3 |
| β-strand | 151-164 | 14 | 3 |
| α-helix | 165-167 | 3 | |
| β-strand | 169-182 | 14 | 3 |
| β-strand | 185-198 | 14 | 3 |
| β-strand | 202-217 | 16 | 3 |
| α-helix | 221-249 | 29 | |
| α-helix | 250-255 | 6 | |
| α-helix | 256-258 | 3 | |
| α-helix | 271-275 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 5-13 | 9 | |
| α-helix | 18-20 | 3 | |
| α-helix | 21-31 | 11 | |
| α-helix | 33-35 | 3 | |
| α-helix | 36-42 | 7 | |
| β-strand | 48-52 | 5 | 4 |
| β-strand | 57-61 | 5 | 4 |
| α-helix | 63-65 | 3 | |
| β-strand | 66-67 | 2 | 5 |
| β-strand | 70-72 | 3 | 5 |
| β-strand | 79-80 | 2 | 5 |
| α-helix | 91-112 | 22 | |
| β-strand | 116-124 | 9 | 3 |
| β-strand | 127-137 | 11 | 3 |
| α-helix | 141-143 | 3 | |
| β-strand | 144-158 | 15 | 3 |
| β-strand | 164-181 | 18 | 3 |
| β-strand | 185-202 | 18 | 3 |
| α-helix | 209-230 | 22 | |
| α-helix | 231-235 | 5 | |
| α-helix | 236-243 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 489-492 | 4 | |
| α-helix | 494-495 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| F-actin-capping protein subunit alpha-1 | A | protein | 286 | Gallus gallus | P13127 (AlphaFold model) |
| F-actin-capping protein subunit beta isoforms 1 | B | protein | 244 | Gallus gallus | P14315 (AlphaFold model) |
| CD2-associated protein,Twinfilin-1 | C | protein | 28 | Homo sapiens, Mus musculus | Q91YR1 (AlphaFold model), Q9Y5K6 (AlphaFold model) |
>7DS8_1 F-actin-capping protein subunit alpha-1 (chains A) MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMD QFTPVKIEGYDDQVLITEHGDLGNGRFLDPRNKISFKFDHLRKEASDPQPEDTESALKQW RDACDSALRAYVKDHYPNGFCTVYGKSIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFT ITPPTAQVAAVLKIQVHYYEDGNVQLVSHKDIQDSVQVSSDVQTAKEFIKIIENAENEYQ TAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
>7DS8_2 F-actin-capping protein subunit beta isoforms 1 (chains B) MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYL LCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVY LWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTN KTGSGTMNLGGSLTRQMEKDETVSDSSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIV NGLR
>7DS8_3 CD2-associated protein,Twinfilin-1 (chains C) NLLHLTANRPKGPAGKRGIRRLIRGPAE
Structural Insights into the Regulation of Actin Capping Protein by Twinfilin C-terminal Tail. Takeda, S., Koike, R., Fujiwara, I. et al. J Mol Biol (2021) 433:166891-166891. DOI 10.1016/j.jmb.2021.166891 · PubMed
Other PDB entries of the same protein (UniProt P13127 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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