voltage-gated sodium channel Nav1.5-E1784K. Determined by electron microscopy at 3.3 Å resolution. Released 24 Mar 2021.
Explore 7DTC in 3D Show helices and sheets RCSB PDB PDBe
7DTC contains 62 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 121-128 | 8 | |
| α-helix | 131-148 | 18 | |
| α-helix | 158-176 | 19 | |
| α-helix | 192-206 | 15 | |
| α-helix | 219-230 | 12 | |
| α-helix | 236-247 | 12 | |
| α-helix | 248-250 | 3 | |
| α-helix | 251-272 | 22 | |
| β-strand | 278-281 | 4 | 1 |
| β-strand | 285 | 1 | 2 |
| β-strand | 296 | 1 | 2 |
| β-strand | 300 | 1 | 2 |
| α-helix | 305-309 | 5 | |
| β-strand | 316 | 1 | 3 |
| α-helix | 317 | 1 | |
| β-strand | 323 | 1 | 3 |
| β-strand | 340-343 | 4 | 1 |
| α-helix | 349-351 | 3 | |
| α-helix | 358-369 | 12 | |
| α-helix | 374-385 | 12 | |
| α-helix | 387-389 | 3 | |
| α-helix | 390-395 | 6 | |
| α-helix | 396-403 | 8 | |
| α-helix | 404-428 | 25 | |
| α-helix | 700-714 | 15 | |
| α-helix | 717-735 | 19 | |
| β-strand | 738 | 1 | 4 |
| α-helix | 741-742 | 2 | |
| α-helix | 745-768 | 24 | |
| α-helix | 773-776 | 4 | |
| α-helix | 782-797 | 16 | |
| α-helix | 809-812 | 4 | |
| α-helix | 813-819 | 7 | |
| α-helix | 825-833 | 9 | |
| α-helix | 834-838 | 5 | |
| α-helix | 842-869 | 28 | |
| α-helix | 885-896 | 12 | |
| α-helix | 901-910 | 10 | |
| α-helix | 912-943 | 32 | |
| α-helix | 1191-1203 | 13 | |
| α-helix | 1205-1220 | 16 | |
| α-helix | 1235-1261 | 27 | |
| α-helix | 1264-1267 | 4 | |
| α-helix | 1272-1292 | 21 | |
| α-helix | 1300-1303 | 4 | |
| α-helix | 1306-1313 | 8 | |
| α-helix | 1318-1329 | 12 | |
| α-helix | 1332-1356 | 25 | |
| β-strand | 1361-1362 | 2 | 5 |
| β-strand | 1365 | 1 | 6 |
| β-strand | 1380 | 1 | 7 |
| α-helix | 1381-1384 | 4 | |
| β-strand | 1393 | 1 | 6 |
| β-strand | 1396-1397 | 2 | 5 |
| β-strand | 1404 | 1 | 4 |
| α-helix | 1405-1417 | 13 | |
| α-helix | 1421-1428 | 8 | |
| β-strand | 1436 | 1 | 7 |
| α-helix | 1444-1446 | 3 | |
| α-helix | 1447-1453 | 7 | |
| α-helix | 1454-1460 | 7 | |
| α-helix | 1461-1479 | 19 | |
| α-helix | 1489-1498 | 10 | |
| α-helix | 1506-1508 | 3 | |
| α-helix | 1516-1525 | 10 | |
| α-helix | 1530-1546 | 17 | |
| α-helix | 1554-1581 | 28 | |
| α-helix | 1592-1608 | 17 | |
| α-helix | 1622-1626 | 5 | |
| α-helix | 1627-1629 | 3 | |
| α-helix | 1630-1634 | 5 | |
| α-helix | 1635-1637 | 3 | |
| α-helix | 1641-1651 | 11 | |
| α-helix | 1654-1678 | 25 | |
| β-strand | 1682 | 1 | 8 |
| β-strand | 1685 | 1 | 9 |
| β-strand | 1688 | 1 | 9 |
| α-helix | 1697-1708 | 12 | |
| α-helix | 1713-1717 | 5 | |
| β-strand | 1741 | 1 | 8 |
| α-helix | 1745-1778 | 34 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Sodium channel protein type 5 subunit alpha | A | protein | 2059 | Homo sapiens | Q14524 (AlphaFold model) |
>7DTC_1 Sodium channel protein type 5 subunit alpha (chains A) MASWSHPQFEKGGGARGGSGGGSWSHPQFEKGFDYKDDDDKGTMANFLLPRGTSSFRRFT RESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIG EPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLI MCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLD FSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLT VFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLK NGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERL YQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEA MEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKS DSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESH HTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSH LLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELE ESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALE HYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELG LSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVG MQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLL VFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTT WDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQG TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQ VSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDL GQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILL SSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFL IVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNV LLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTK VKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFG SFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKY QGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIV KLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLI RGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTF ANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYII ISFLIVVNMYIAIILENFSVATEESTKPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDF ADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEE KFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLS EEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSH SEDLADFPPSPDRDRESIV
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 9 |
Structure of human Na v 1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Li, Z., Jin, X., Wu, T. et al. Proc Natl Acad Sci U S A (2021) 118. DOI 10.1073/pnas.2100069118 · PubMed
Other PDB entries of the same protein (UniProt Q14524 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 7DTC directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.