7N8J: Human importin alpha 1

Human importin alpha 1 in complex with Bimax2 peptide. Determined by X-ray diffraction at 3.2 Å resolution. Released 30 Jun 2021.

Method: X-ray diffraction
Resolution: 3.2 Å
Organisms: Homo sapiens, synthetic construct
Chains: 2
Atoms: 3,472
Mol. weight: 52.93 kDa
Released: 30 Jun 2021

Explore 7N8J in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7N8J contains 32 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 30 helices, 0 β-strands

Element	Residues	Length
α-helix	78-85	8
α-helix	90-105	16
α-helix	112-117	6
α-helix	121-128	8
α-helix	134-148	15
α-helix	152-160	9
α-helix	163-170	8
α-helix	176-192	17
α-helix	194-202	9
α-helix	206-213	8
α-helix	223-236	14
α-helix	243-245	3
α-helix	246-259	14
α-helix	265-279	15
α-helix	283-290	8
α-helix	295-302	8
α-helix	307-320	14
α-helix	325-333	9
α-helix	336-339	4
α-helix	340-344	5
α-helix	349-362	14
α-helix	367-375	9
α-helix	378-387	10
α-helix	391-407	17
α-helix	410-418	9
α-helix	422-426	5
α-helix	434-454	21
α-helix	457-466	10
α-helix	469-475	7
α-helix	482-495	14

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	4-7	4
α-helix	17-19	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Importin subunit alpha-1	A	protein	454	Homo sapiens	P52292 (AlphaFold model)
BIMAX2	B	protein	28	synthetic construct

Sequence of entity 1 (A), FASTA

>7N8J_1 Importin subunit alpha-1 (chains A)
WSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSP
IQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSV
FRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPT
LVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALR
AIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVN
HGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTK
IILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKY
FSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

Sequence of entity 2 (B), FASTA

>7N8J_2 BIMAX2 (chains B)
GSRRRRRRKRKREWDDDDDPPKKRRRLD

Primary citation

Human importin alpha 1:Bimax2 peptide complex. Donnelly, C.M., Cross, E.M., Tsimbalyuk, S. et al. To be published.

Other PDB entries of the same protein (UniProt P52292 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4WV6 1.75 Å, Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8
8FZK 2.1 Å, Dimeric human importin alpha subunit
3FEY 2.2 Å, Crystal structure of the CBC-importin alpha complex.
7N9H 2.2 Å, Structure of the mammalian importin a1 bound to the TDP-43 NLS
1QGR 2.3 Å, Structure of importin beta bound to the ibb domain of importin alpha (II crystal form,…
5H43 2.3 Å, Structural and mechanistical studies of the nuclear import by Importin-alpha
1QGK 2.5 Å, Structure of importin beta bound to the ibb domain of importin alpha
4E4V 2.53 Å, The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution.
3WPT 2.63 Å, Crystal structure of closed dimer of human importin-alpha1 (Rch1)
7CRU 2.8 Å, hnRNPK NLS in complex with Importin alpha 1 (KPNA2)
1EFX 3.0 Å, Structure of a complex between the human natural killer cell receptor KIR2DL2 and a…
9BFC 3.2 Å, Cryo-EM structure of importin alpha-1/beta bound to FG repeats

Browse structure collections

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