Structure of the C9orf72-SMCR8 complex. Determined by electron microscopy at 3.8 Å resolution. Released 21 Jul 2021.
Explore 7O2W in 3D Show helices and sheets RCSB PDB PDBe
7O2W contains 34 α-helices and 25 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 15-16 | 2 | 1 |
| β-strand | 28-29 | 2 | 2 |
| β-strand | 44 | 1 | 2 |
| β-strand | 45-46 | 2 | 1 |
| α-helix | 56-71 | 16 | |
| β-strand | 81-82 | 2 | 3 |
| β-strand | 85-87 | 3 | 4 |
| β-strand | 92-94 | 3 | 4 |
| β-strand | 97-98 | 2 | 3 |
| β-strand | 113-114 | 2 | 2 |
| β-strand | 115-117 | 3 | 4 |
| α-helix | 121-142 | 22 | |
| α-helix | 168-171 | 4 | |
| α-helix | 173-192 | 20 | |
| α-helix | 214-229 | 16 | |
| β-strand | 237 | 1 | 5 |
| β-strand | 238 | 1 | 6 |
| α-helix | 245-248 | 4 | |
| α-helix | 257-259 | 3 | |
| β-strand | 284 | 1 | 6 |
| α-helix | 285-288 | 4 | |
| α-helix | 295-299 | 5 | |
| β-strand | 306 | 1 | 7 |
| β-strand | 309 | 1 | 5 |
| β-strand | 317 | 1 | 7 |
| α-helix | 325-333 | 9 | |
| β-strand | 368 | 1 | 7 |
| α-helix | 375-384 | 10 | |
| α-helix | 385-387 | 3 | |
| α-helix | 393-418 | 26 | |
| β-strand | 422 | 1 | 8 |
| β-strand | 425 | 1 | 8 |
| α-helix | 430-436 | 7 | |
| α-helix | 442-453 | 12 | |
| α-helix | 459-464 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 115-117 | 3 | 4 |
| β-strand | 135-136 | 2 | 4 |
| β-strand | 140 | 1 | 9 |
| α-helix | 147-149 | 3 | |
| β-strand | 152 | 1 | 9 |
| α-helix | 163-166 | 4 | |
| α-helix | 169-212 | 44 | |
| α-helix | 225-248 | 24 | |
| α-helix | 315-330 | 16 | |
| α-helix | 333-344 | 12 | |
| α-helix | 349-362 | 14 | |
| α-helix | 367-370 | 4 | |
| α-helix | 702-704 | 3 | |
| α-helix | 705-714 | 10 | |
| α-helix | 720-729 | 10 | |
| β-strand | 734 | 1 | 10 |
| α-helix | 740-748 | 9 | |
| α-helix | 750-753 | 4 | |
| β-strand | 783 | 1 | 10 |
| α-helix | 795-802 | 8 | |
| α-helix | 826-830 | 5 | |
| α-helix | 841-862 | 22 | |
| α-helix | 878-889 | 12 | |
| α-helix | 895-915 | 21 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72 | A | protein | 593 | Saccharomyces cerevisiae S288c, Homo sapiens | Q12306 (AlphaFold model), Q96LT7 (AlphaFold model) |
| Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein… | B | protein | 1206 | Homo sapiens, Escherichia coli K-12 | P0AEX9 (AlphaFold model), Q8TEV9 (AlphaFold model) |
>7O2W_1 Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72 (chains A) MAHHHHHHGSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAF AKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQISSGLDAAAMSTLCPPP SPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLN GEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLH RVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLS SMKSHSVPEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIV RTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHI DVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQ DVLHRDTLVKAFLDQVFQLKPGLSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFK SLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMTF
>7O2W_2 Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein (chains B) MDSAWSHPQFEKGGGSGGGSGGSAWSHPQFEKSAVDLEVLFQGPGMISAPDVVAFTKEEE YEEEPYNEPALPEEYSVPLFPFASQGANPWSKLSGAKFSRDFILISEFSEQVGPQPLLTI PNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVEDSKVVLGDSKEGAFAY VHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSRASECLKTGNRKAFAGEL EKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVEKSIIEHQDLLKQIRS YPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRPAYTPKLIKAKSTKCF DKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRALLKQQHITNFLFEDF VEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGD EEYKDTGSTGSTSGTLEVLFQGPGRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPS HLLASRDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNALKFIR QYPFAHPAIYSLLSGRTLVVLGEDEAIVRKLVTALAIFVPSYGCYAKPVKHWASSPLHIM DFQKWKLIGLQRVASPAGAGTLHALSRYSRYTSILDLDNKTLRCPLYRGTLVPRLADHRT QIKRGSTYYLHVQSMLTQLCSKAFLYTFCHHLHLPTHDKETEELVASRQMSFLKLTLGLV NEDVRVVQYLAELLKLHYMQESPGTSHPMLRFDYVPSFLYKIGGSGSENLYFQGGTSSGM KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDII FWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKD LLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKD VGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKV NYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEA LKDAQT
Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture. Norpel, J., Cavadini, S., Schenk, A.D. et al. PLoS Biol (2021) 19:e3001344-e3001344. DOI 10.1371/journal.pbio.3001344 · PubMed
Other PDB entries of the same protein (UniProt Q12306 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 7O2W directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.