Galectin-8 N-terminal carbohydrate recognition domain in complex with benzimidazole D-galactal ligand. Determined by X-ray diffraction at 1.52 Å resolution. Released 15 Dec 2021.
Explore 7P1M in 3D Show helices and sheets RCSB PDB PDBe
7P1M contains 4 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 9-13 | 5 | 1 |
| β-strand | 19-22 | 4 | 2 |
| β-strand | 32-38 | 7 | 1 |
| β-strand | 45-52 | 8 | 2 |
| α-helix | 60 | 1 | |
| β-strand | 61-69 | 9 | 2 |
| β-strand | 75-82 | 8 | 2 |
| β-strand | 85-86 | 2 | 2 |
| β-strand | 90-92 | 3 | 2 |
| β-strand | 102-109 | 8 | 1 |
| β-strand | 113-118 | 6 | 1 |
| β-strand | 121-127 | 7 | 1 |
| α-helix | 132-134 | 3 | |
| β-strand | 137-142 | 6 | 2 |
| β-strand | 145-152 | 8 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 9-13 | 5 | 3 |
| β-strand | 19-22 | 4 | 4 |
| β-strand | 32-38 | 7 | 3 |
| β-strand | 45-51 | 7 | 4 |
| α-helix | 60-61 | 2 | |
| β-strand | 62-69 | 8 | 4 |
| β-strand | 75-82 | 8 | 4 |
| β-strand | 85-86 | 2 | 4 |
| β-strand | 90-92 | 3 | 4 |
| β-strand | 102-109 | 8 | 3 |
| β-strand | 113-118 | 6 | 3 |
| β-strand | 121-127 | 7 | 3 |
| α-helix | 132-134 | 3 | |
| β-strand | 137-142 | 6 | 4 |
| β-strand | 145-152 | 8 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Galectin-8 | A, B | protein | 151 | Homo sapiens | O00214 (AlphaFold model) |
>7P1M_1 Galectin-8 (chains A, B) NNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFH FNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLL YGHRIGPEKIDTLGIYGKVNIHSIGFSFSSD
| ID | Name | Formula | Copies |
|---|---|---|---|
| 4IU | 2-[[(2R,3R,4R)-2-(hydroxymethyl)-3-oxidanyl-3,4-dihydro-2H-pyran-4-yl]oxymethyl… | C16 H18 N2 O6 | 2 |
Water and common crystallization additives (CL) are not listed.
Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain. Hassan, M., Baussiere, F., Guzelj, S. et al. ACS Med Chem Lett (2021) 12:1745-1752. DOI 10.1021/acsmedchemlett.1c00371 · PubMed
Other PDB entries of the same protein (UniProt O00214 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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