7PT7: MCM2-7 DH

Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ADP:BeF3, state I. Determined by electron microscopy at 3.8 Å resolution. Released 8 Jun 2022.

Method: Electron microscopy
Resolution: 3.8 Å
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Chains: 15
Atoms: 67,420
Mol. weight: 1359.45 kDa
Ligands: BEF, ZN, MG, ADP
Released: 8 Jun 2022

Explore 7PT7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7PT7 contains 399 α-helices and 402 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 2: 31 helices, 32 β-strands

Element	Residues	Length	Sheet
α-helix	183-187	5
α-helix	194-198	5
α-helix	201-217	17
β-strand	219	1	1
β-strand	225	1	1
α-helix	226-237	12
β-strand	241-242	2	2
β-strand	245	1	3
α-helix	246-252	7
α-helix	254-262	9
α-helix	264-282	19
β-strand	294-295	2	2
β-strand	298	1	3
α-helix	306-308	3
β-strand	316-327	12	4
β-strand	333-338	6	5
β-strand	339	1	6
β-strand	340	1	5
β-strand	347-352	6	5
α-helix	353-354	2
β-strand	375	1	6
β-strand	381-383	3	5
β-strand	385-391	7	4
α-helix	398	1
α-helix	402-404	3
β-strand	405-411	7	4
α-helix	412-414	3
β-strand	423-432	10	4
α-helix	433-434	2
β-strand	446	1	7
β-strand	449-452	4	4
β-strand	455-458	4	4
α-helix	478-489	12
α-helix	493-500	8
α-helix	509-520	12
β-strand	527	1	8
β-strand	531	1	8
β-strand	539-543	5	9
α-helix	549-559	11
β-strand	563-567	5	9
β-strand	579-582	4	10
α-helix	583	1
β-strand	589-592	4	10
α-helix	595-598	4
β-strand	603-607	5	9
α-helix	614-626	13
β-strand	628-631	4	11
β-strand	638-641	4	11
β-strand	645-650	6	9
α-helix	653-655	3
α-helix	663-666	4
α-helix	671-676	6
β-strand	679-683	5	9
α-helix	689-705	17
α-helix	760-773	14
β-strand	777	1	12
α-helix	783-800	18
α-helix	803-805	3
α-helix	807-823	17
β-strand	828	1	12
α-helix	831-847	17
α-helix	855-858	4
α-helix	861-863	3

Chain 3: 28 helices, 34 β-strands

Element	Residues	Length	Sheet
α-helix	19-34	16
α-helix	36-55	20
α-helix	91-93	3
β-strand	95-99	5	13
α-helix	100-106	7
α-helix	108-116	9
α-helix	118-136	19
β-strand	154-158	5	13
α-helix	162-164	3
β-strand	165-166	2	14
α-helix	173-175	3
β-strand	179-189	11	14
β-strand	195-203	9	15
β-strand	208-213	6	15
β-strand	234	1	16
β-strand	240	1	16
β-strand	241-243	3	15
β-strand	249-251	3	15
β-strand	253-259	7	14
α-helix	266	1
β-strand	273-279	7	14
α-helix	280-282	3
β-strand	291-301	11	14
β-strand	317	1	17
β-strand	318-325	8	14
β-strand	328-330	3	14
α-helix	344-353	10
α-helix	359-367	9
α-helix	375-386	12
β-strand	391-392	2	18
β-strand	398-399	2	18
β-strand	405-409	5	19
α-helix	415-425	11
β-strand	429-432	4	19
β-strand	444-446	3	20
β-strand	457-459	3	20
α-helix	461-464	4
β-strand	468-473	6	19
α-helix	475-477	3
α-helix	480-484	5
α-helix	486-491	6
β-strand	494-496	3	21
β-strand	499	1	22
β-strand	502	1	22
β-strand	505-507	3	21
β-strand	510-516	7	19
α-helix	529-533	5
α-helix	537-542	6
β-strand	545-549	5	19
α-helix	555-569	15
α-helix	580-584	5
β-strand	589-590	2	14
β-strand	622	1	23
α-helix	650	1
β-strand	651	1	23
α-helix	652	1
α-helix	653-666	14
β-strand	670	1	24
α-helix	673-688	16
α-helix	699-715	17
β-strand	720	1	24
α-helix	723-737	15

Chain 4: 34 helices, 34 β-strands

Element	Residues	Length	Sheet
α-helix	179-180	2
α-helix	187-199	13
α-helix	203-209	7
α-helix	218-221	4
α-helix	225-236	12
β-strand	240-241	2	25
β-strand	244	1	26
α-helix	245-250	6
α-helix	252-254	3
α-helix	255-263	9
α-helix	265-287	23
α-helix	293-297	5
β-strand	302-303	2	25
β-strand	306	1	26
α-helix	319-321	3
β-strand	325-335	11	27
α-helix	336-338	3
β-strand	339-344	6	27
β-strand	345	1	28
β-strand	347-349	3	29
β-strand	354-355	2	29
β-strand	358	1	28
β-strand	361	1	30
β-strand	364	1	30
α-helix	366-368	3
β-strand	382-384	3	29
β-strand	390-401	12	27
β-strand	414-420	7	27
α-helix	421-423	3
α-helix	428	1
β-strand	433-445	13	27
β-strand	453-455	3	27
β-strand	456	1	31
β-strand	457-462	6	27
β-strand	465-466	2	27
α-helix	474-477	4
α-helix	482-491	10
α-helix	503-513	11
α-helix	518-524	7
α-helix	534-545	12
β-strand	564-567	4	32
α-helix	574-584	11
β-strand	591-592	2	32
α-helix	593-595	3
β-strand	596	1	33
β-strand	603-607	5	34
β-strand	614-618	5	34
α-helix	620-623	4
β-strand	628-632	5	32
α-helix	639-643	5
α-helix	645-650	6
β-strand	653-658	6	35
β-strand	661-666	6	35
β-strand	670-675	6	32
α-helix	688-692	5
α-helix	696-701	6
β-strand	704-706	3	32
α-helix	714-726	13
α-helix	733-735	3
α-helix	744-757	14
β-strand	761	1	36
α-helix	764-777	14
α-helix	790-793	4
α-helix	795-811	17
β-strand	816	1	36
α-helix	819-832	14
β-strand	838	1	37
β-strand	845	1	37

Chain 5: 24 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	4-7	4
β-strand	8	1	38
β-strand	11-12	2	38
α-helix	18-20	3
α-helix	24-37	14
β-strand	40	1	39
β-strand	43	1	39
α-helix	45-55	11
β-strand	60-64	5	40
α-helix	66-71	6
α-helix	73-81	9
α-helix	83-106	24
α-helix	134-135	2
β-strand	136-140	5	40
α-helix	148-150	3
β-strand	159-169	11	41
β-strand	173-183	11	17
β-strand	188-193	6	17
β-strand	241-253	13	17
β-strand	256-259	4	41
β-strand	273-277	5	41
β-strand	279	1	17
α-helix	280-282	3
β-strand	291-301	11	41
β-strand	323	1	5
β-strand	325-335	11	41
α-helix	351-361	11
α-helix	366-373	8
α-helix	382-393	12
β-strand	398-399	2	42
β-strand	405-406	2	42
β-strand	412-416	5	43
α-helix	422-432	11
β-strand	436-440	5	43
β-strand	453-455	3	44
β-strand	462-464	3	44
α-helix	468-471	4
β-strand	476-480	5	43
α-helix	487-498	12
β-strand	501-504	4	45
β-strand	511-514	4	45
β-strand	518-523	6	43
α-helix	536-539	4
α-helix	544-549	6
β-strand	552-556	5	43
α-helix	562-575	14
α-helix	596-609	14
β-strand	613	1	46
α-helix	616-639	24
α-helix	643-644	2
α-helix	650-666	17
β-strand	671	1	46
α-helix	674-687	14

Chain 6: 26 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	106-120	15
β-strand	125	1	47
β-strand	132	1	47
α-helix	135-145	11
β-strand	150-154	5	48
α-helix	155-160	6
α-helix	161-164	4
α-helix	165-172	8
α-helix	174-191	18
β-strand	198	1	49
β-strand	260	1	49
β-strand	264-268	5	48
β-strand	273-274	2	7
β-strand	287-297	11	7
β-strand	301-310	10	7
β-strand	318-322	5	7
β-strand	345-346	2	7
β-strand	352-362	11	7
α-helix	363-364	2
α-helix	368-369	2
β-strand	376-382	7	7
α-helix	383-385	3
β-strand	394-405	12	7
β-strand	450-461	12	7
α-helix	501-507	7
α-helix	510-520	11
α-helix	526-531	6
α-helix	542-552	11
β-strand	557-558	2	50
β-strand	564-565	2	50
β-strand	571-574	4	51
β-strand	575	1	52
α-helix	581-588	8
β-strand	596-599	4	51
β-strand	603	1	35
α-helix	605-608	4
β-strand	611-614	4	53
β-strand	621-624	4	53
α-helix	627-630	4
β-strand	635-639	5	51
α-helix	646-658	13
β-strand	660-662	3	54
β-strand	665	1	55
β-strand	668	1	55
β-strand	671-673	3	54
β-strand	677-682	6	51
α-helix	683-684	2
α-helix	685-687	3
α-helix	696-698	3
α-helix	703-708	6
β-strand	711-712	2	51
β-strand	715	1	52
α-helix	721-736	16
α-helix	748-760	13
β-strand	764-765	2	56
α-helix	767-783	17
α-helix	797-813	17
β-strand	818-819	2	56
α-helix	821-834	14

Chain 7: 33 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	15
α-helix	14-26	13
α-helix	62-71	10
β-strand	77-81	5	57
α-helix	82-95	14
α-helix	102-123	22
α-helix	125-128	4
α-helix	138-164	27
α-helix	178-188	11
α-helix	194-197	4
β-strand	201-205	5	57
α-helix	206-208	3
α-helix	209-211	3
β-strand	224-225	2	31
α-helix	227-229	3
β-strand	238-247	10	31
α-helix	249-251	3
β-strand	252-262	11	31
β-strand	267-272	6	31
β-strand	277-278	2	27
α-helix	287-291	5
β-strand	298-300	3	31
β-strand	306-316	11	31
β-strand	330-336	7	31
α-helix	337-339	3
β-strand	348-359	12	31
β-strand	371	1	15
β-strand	372-383	12	31
α-helix	395-406	12
α-helix	410-417	8
α-helix	427-437	11
β-strand	442-443	2	58
β-strand	449-450	2	58
β-strand	456-458	3	59
α-helix	466-476	11
β-strand	484	1	59
α-helix	488-491	4
β-strand	497	1	60
α-helix	507	1
β-strand	508	1	60
α-helix	509-510	2
α-helix	512-515	4
β-strand	520	1	61
β-strand	523-524	2	59
α-helix	531-543	13
β-strand	545-547	3	62
β-strand	549	1	33
β-strand	556-558	3	62
β-strand	562	1	61
β-strand	564-566	3	59
α-helix	568-569	2
α-helix	580-584	5
α-helix	588-593	6
β-strand	596-598	3	59
α-helix	606-621	16
α-helix	632-634	3
α-helix	635-647	13
β-strand	651	1	63
α-helix	654-673	20
α-helix	686-703	18
β-strand	707	1	63
α-helix	710-722	13
α-helix	725-727	3

Chain 8: 18 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	13-25	13
β-strand	33-41	9	64
β-strand	45-52	8	64
α-helix	56-59	4
β-strand	73-78	6	64
α-helix	84-96	13
β-strand	103	1	65
α-helix	104-106	3
β-strand	108-112	5	64
β-strand	115-121	7	64
α-helix	128-131	4
α-helix	137-157	21
β-strand	159-160	2	66
α-helix	166-168	3
β-strand	169-172	4	65
β-strand	177-180	4	65
β-strand	187-188	2	66
β-strand	264-266	3	67
α-helix	272-274	3
β-strand	281	1	68
β-strand	283	1	68
α-helix	287-290	4
α-helix	299-312	14
α-helix	325-335	11
α-helix	338-347	10
β-strand	350-355	6	69
α-helix	369-383	15
α-helix	392-402	11
α-helix	425-449	25
α-helix	458-459	2
α-helix	460-464	5
α-helix	472-474	3

Chain 9: 15 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	112-115	4
β-strand	126	1	70
α-helix	138-156	19
β-strand	172	1	70
β-strand	173-174	2	71
α-helix	190-197	8
β-strand	201-202	2	71
α-helix	204-214	11
α-helix	234-241	8
β-strand	258-260	3	67
β-strand	265-270	6	69
β-strand	279-282	4	69
α-helix	286-288	3
α-helix	320-332	13
α-helix	334-343	10
α-helix	374-384	11
α-helix	519-521	3
α-helix	522-529	8
β-strand	531	1	72
β-strand	659-661	3	73
β-strand	666-668	3	73
α-helix	671-675	5
α-helix	678-685	8
α-helix	687-690	4
α-helix	691-700	10

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Undefined Mcm4 flexible N-terminal tail	1	protein	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
DNA replication licensing factor MCM2	2, B	protein	868	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P29469 (AlphaFold model)
DNA replication licensing factor MCM3	3, C	protein	971	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P24279 (AlphaFold model)
DNA replication licensing factor MCM4	4, D	protein	933	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P30665 (AlphaFold model)
Minichromosome maintenance protein 5	5, E	protein	775	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P29496 (AlphaFold model)
DNA replication licensing factor MCM6	6, F	protein	1017	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P53091
DNA replication licensing factor MCM7	7, G	protein	845	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P38132
Cell division control protein 7	8	protein	507	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P06243
DDK kinase regulatory subunit DBF4	9	protein	704	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P32325

Sequence of entity 1 (1), FASTA

>7PT7_1 Undefined Mcm4 flexible N-terminal tail (chains 1)
XXXX

Sequence of entity 2 (2, B), FASTA

>7PT7_2 DNA replication licensing factor MCM2 (chains 2, B)
MSDNRRRRREEDDSDSENELPPSSPQQHFRGGMNPVSSPIGSPDMINPEGDDNEVDDVPD
IDEVEEQMNEVDLMDDNMYEDYAADHNRDRYDPDQVDDREQQELSLSERRRIDAQLNERD
RLLRNVAYIDDEDEEQEGAAQLDEMGLPVQRRRRRRQYEDLENSDDDLLSDMDIDPLREE
LTLESLSNVKANSYSEWITQPNVSRTIARELKSFLLEYTDETGRSVYGARIRTLGEMNSE
SLEVNYRHLAESKAILALFLAKCPEEMLKIFDLVAMEATELHYPDYARIHSEIHVRISDF
PTIYSLRELRESNLSSLVRVTGVVTRRTGVFPQLKYVKFNCLKCGSILGPFFQDSNEEIR
ISFCTNCKSKGPFRVNGEKTVYRNYQRVTLQEAPGTVPPGRLPRHREVILLADLVDVSKP
GEEVEVTGIYKNNYDGNLNAKNGFPVFATIIEANSIKRREGNTANEGEEGLDVFSWTEEE
EREFRKISRDRGIIDKIISSMAPSIYGHRDIKTAVACSLFGGVPKNVNGKHSIRGDINVL
LLGDPGTAKSQILKYVEKTAHRAVFATGQGASAVGLTASVRKDPITKEWTLEGGALVLAD
KGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTTLQARCSIIAAANPNGGRYNST
LPLAQNVSLTEPILSRFDILCVVRDLVDEEADERLATFVVDSHVRSHPENDEDREGEELK
NNGESAIEQGEDEINEQLNARQRRLQRQRKKEEEISPIPQELLMKYIHYARTKIYPKLHQ
MDMDKVSRVYADLRRESISTGSFPITVRHLESILRIAESFAKMRLSEFVSSYDLDRAIKV
VVDSFVDAQKVSVRRQLRRSFAIYTLGH

Sequence of entity 3 (3, C), FASTA

>7PT7_3 DNA replication licensing factor MCM3 (chains 3, C)
MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNDDQ
DDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLREFDRSFWSGILVEPAY
FIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGAHALSPRTLTAQHLNKLV
SVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLTTRIPTPAIYPTEDTEGNK
LTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKS
LGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQMLTDFDIRNINKLSKKKDIF
DILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTAKSQLLR
FVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMTD
VDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPVFGQYDVNRDPHQNIALPDSLL
SRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGYLEGEPVRERLNLSLAVGEDADINP
EEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKLAKNKGNYNGTEIPKLVTIPFLRKYV
QYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKKSPITARTLETLIRLATAHAKVRLSKT
VNKVDAKVAANLLRFALLGEDIGNDIDEEESEYEEALSKRSPQKSPKKRQRVRQPASNSG
SPIKSTPRRSTASSVNATPSSARRILRFQDDEQNAGEDDNDIMSPLPADEEAELQRRLQL
GLRVSPRRREHLHAPEEGSSGPLTEVGTPRLPNVSSAGQDDEQQQSVISFDNVEPGTIST
GRLSLISGIIARLMQTEIFEEESYPVASLFERINEELPEEEKFSAQEYLAGLKIMSDRNN
LMVADDKVWRV

Sequence of entity 4 (4, D), FASTA

>7PT7_4 DNA replication licensing factor MCM4 (chains 4, D)
MSQQSSSPTKEDNNSSSPVVPNPDSVPPQLSSPALFYSSSSSQGDIYGRNNSQNLSQGEG
NIRAAIGSSPLNFPSSSQRQNSDVFQSQGRQGRIRSSASASGRSRYHSDLRSDRALPTSS
SSLGRNGQNRVHMRRNDIHTSDLSSPRRIVDFDTRSGVNTLDTSSSSAPPSEASEPLRII
WGTNVSIQECTTNFRNFLMSFKYKFRKILDEREEFINNTTDEELYYIKQLNEMRELGTSN
LNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLIVDNNLDYDLDEIETKF
YKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLRSTPVIPDMKVAFFKCNVCDHTMAVEI
DRGVIQEPARCERIDCNEPNSMSLIHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVY
DELVDSCRAGDRIEVTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKKVSDKRLDVDTST
IEQELMQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELEDVKKGI
LLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKITPRGVYTSGKGSSAVG
LTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAG
IITTLNARSSILASANPIGSRYNPNLPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDREL
AKHLTNLYLEDKPEHISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKM
GDDSRSDEKRITATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYATDP
KTGKIDMNLVQTGKSVIQRKLQEDLSREIMNVLKDQASDSMSFNELIKQINEHSQDRVES
SDIQEALSRLQQEDKVIVLGEGVRRSVRLNNRV

Sequence of entity 5 (5, E), FASTA

>7PT7_5 Minichromosome maintenance protein 5 (chains 5, E)
MSFDRPEIYSAPVLQGESPNDDDNTEIIKSFKNFILEFRLDSQFIYRDQLRNNILVKNYS
LTVNMEHLIGYNEDIYKKLSDEPSDIIPLFETAITQVAKRISILSRAQSANNNDKDPENT
SMDTDSLLLNSLPTFQLILNSNANQIPLRDLDSEHVSKIVRLSGIIISTSVLSSRATYLS
IMCRNCRHTTSITINNFNSITGNTVSLPRSCLSTIESESSMANESNIGDESTKKNCGPDP
YIIIHESSKFIDQQFLKLQEIPELVPVGEMPRNLTMTCDRYLTNKVIPGTRVTIVGIYSI
YNSKNGAGSGRSGGGNGGSGVAIRTPYIKILGIQSDVETSSIWNSVTMFTEEEEEEFLQL
SRNPKLYEILTNSIAPSIFGNEDIKKAIVCLLMGGSKKILPDGMRLRGDINVLLLGDPGT
AKSQLLKFVEKVSPIAVYTSGKGSSAAGLTASVQRDPMTREFYLEGGAMVLADGGVVCID
EFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPIYGRYDDLKSPGDNI
DFQTTILSRFDMIFIVKDDHNEERDISIANHVINIHTGNANAMQNQQEENGSEISIEKMK
RYITYCRLKCAPRLSPQAAEKLSSNFVTIRKQLLINELESTERSSIPITIRQLEAIIRIT
ESLAKLELSPIAQERHVDEAIRLFQASTMDAASQDPIGGLNQASGTSLSEIRRFEQELKR
RLPIGWSTSYQTLRREFVDTHRFSQLALDKALYALEKHETIQLRHQGQNIYRSGV

Sequence of entity 6 (6, F), FASTA

>7PT7_6 DNA replication licensing factor MCM6 (chains 6, F)
MSSPFPADTPSSNRPSNSSPPPSSIGAGFGSSSGLDSQIGSRLHFPSSSQPHVSNSQTGP
FVNDSTQFSSQRLQTDGSATNDMEGNEPARSFKSRALNHVKKVDDVTGEKVREAFEQFLE
DFSVQSTDTGEVEKVYRAQIEFMKIYDLNTIYIDYQHLSMRENGALAMAISEQYYRFLPF
LQKGLRRVVRKYAPELLNTSDSLKRSEGDEGQADEDEQQDDDMNGSSLPRDSGSSAAPGN
GTSAMATRSITTSTSPEQTERVFQISFFNLPTVHRIRDIRSEKIGSLLSISGTVTRTSEV
RPELYKASFTCDMCRAIVDNVEQSFKYTEPTFCPNPSCENRAFWTLNVTRSRFLDWQKVR
IQENANEIPTGSMPRTLDVILRGDSVERAKPGDRCKFTGVEIVVPDVTQLGLPGVKPSST
LDTRGISKTTEGLNSGVTGLRSLGVRDLTYKISFLACHVISIGSNIGASSPDANSNNRET
ELQMAANLQANNVYQDNERDQEVFLNSLSSDEINELKEMVKDEHIYDKLVRSIAPAVFGH
EAVKKGILLQMLGGVHKSTVEGIKLRGDINICVVGDPSTSKSQFLKYVVGFAPRSVYTSG
KASSAAGLTAAVVRDEEGGDYTIEAGALMLADNGICCIDEFDKMDISDQVAIHEAMEQQT
ISIAKAGIHATLNARTSILAAANPVGGRYNRKLSLRGNLNMTAPIMSRFDLFFVILDDCN
EKIDTELASHIVDLHMKRDEAIEPPFSAEQLRRYIKYARTFKPILTKEARSYLVEKYKEL
RKDDAQGFSRSSYRITVRQLESMIRLSEAIARANCVDEITPSFIAEAYDLLRQSIIRVDV
DDVEMDEEFDNIESQSHAASGNNDDNDDGTGSGVITSEPPADIEEGQSEATARPGTSEKK
KTTVTYDKYVSMMNMIVRKIAEVDREGAEELTAVDIVDWYLLQKENDLGSLAEYWEERRL
AFKVIKRLVKDRILMEIHGTRHNLRDLENEENENNKTVYVIHPNCEVLDQLEPQDSS

Sequence of entity 7 (7, G), FASTA

>7PT7_7 DNA replication licensing factor MCM7 (chains 7, G)
MSAALPSIQLPVDYNNLFNEITDFLVTFKQDTLSSDATRNENEDENLDAENIEQHLLEKG
PKYMAMLQKVANRELNSVIIDLDDILQYQNEKFLQGTQADDLVSAIQQNANHFTELFCRA
IDNNMPLPTKEIDYKDDVLDVILNQRRLRNERMLSDRTNEIRSENLMDTTMDPPSSMNDA
LREVVEDETELFPPNLTRRYFLYFKPLSQNCARRYRKKAISSKPLSVRQIKGDFLGQLIT
VRGIITRVSDVKPAVEVIAYTCDQCGYEVFQEVNSRTFTPLSECTSEECSQNQTKGQLFM
STRASKFSAFQECKIQELSQQVPVGHIPRSLNIHVNGTLVRSLSPGDIVDVTGIFLPAPY
TGFKALKAGLLTETYLEAQFVRQHKKKFASFSLTSDVEERVMELITSGDVYNRLAKSIAP
EIYGNLDVKKALLLLLVGGVDKRVGDGMKIRGDINVCLMGDPGVAKSQLLKAICKISPRG
VYTTGKGSSGVGLTAAVMKDPVTDEMILEGGALVLADNGICCIDEFDKMDESDRTAIHEV
MEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRLSPLDNINLPAALLSRFDILFLM
LDIPSRDDDEKLAEHVTYVHMHNKQPDLDFTPVEPSKMREYIAYAKTKRPVMSEAVNDYV
VQAYIRLRQDSKREMDSKFSFGQATPRTLLGIIRLSQALAKLRLADMVDIDDVEEALRLV
RVSKESLYQETNKSKEDESPTTKIFTIIKKMLQETGKNTLSYENIVKTVRLRGFTMLQLS
NCIQEYSYLNVWHLINEGNTLKFVDDGTMDTDQEDSLVSTPKLAPQTTASANVSAQDSDI
DLQDA

Sequence of entity 8 (8), FASTA

>7PT7_8 Cell division control protein 7 (chains 8)
MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKK
FASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVL
PYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVL
VDFGLAEAQMDYKSMISSQNDYDNYANTNHDGGYSMRNHEQFCPCIMRNQYSPNSHNQTP
PMVTIQNGKVVHLNNVNGVDLTKGYPKNETRRIKRANRAGTRGFRAPEVLMKCGAQSTKI
DIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCAALHGLGFEASGLIWD
KPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHDRMSIEPQLPDPKTNM
DAVDAYELKKYQEEIWSDHYWCFQVLEQCFEMDPQKRSSAEDLLKTPFFNELNENTYLLD
GESTDEDDVVSSSEADLLDKDVLLISE

Sequence of entity 9 (9), FASTA

>7PT7_9 DDK kinase regulatory subunit DBF4 (chains 9)
MVSPTKMIIRSPLKETDTNLKHNNGIAASTTAAGHLNVFSNDNNCNNNNTTESFPKKRSL
ERLELQQQQHLHEKKRARIERARSIEGAVQVSKGTGLKNVEPRVTPKELLEWQTNWKKIM
KRDSRIYFDITDDVEMNTYNKSKMDKRRDLLKRGFLTLGAQITQFFDTTVTIVITRRSVE
NIYLLKDTDILSRAKKNYMKVWSYEKAARFLKNLDVDLDHLSKTKSASLAAPTLSNLLHN
EKLYGPTDRDPRTKRDDIHYFKYPHVYLYDLWQTWAPIITLEWKPQELTNLDELPYPILK
IGSFGRCPFIGDRNYDESSYKRVVKRYSRDKANKKYALQLRALFQYHADTLLNTSSVNDQ
TKNLIFIPHTCNDSTKSFKKWMQEKAKNFEKTELKKTDDSAVQDVRNEHADQTDEKNSIL
LNETETKEPPLKEEKENKQSIAEESNKYPQRKELAATPKLNHPVLATFARQETEEVPDDL
CTLKTKSRQAFEIKASGAHQSNDVATSFGNGLGPTRASVMSKNMKSLSRLMVDRKLGVKQ
TNGNNKNYTATIATTAETSKENRHRLDFNALKKDEAPSKETGKDSAVHLETNRKPQNFPK
VATKSVSADSKVHNDIKITTTESPTASKKSTSTNVTLHFNAQTAQTAQPVKKETVKNSGY
CENCRVKYESLEQHIVSEKHLSFAENDLNFEAIDSLIENLRFQI

Ligands and cofactors

ID	Name	Formula	Copies
BEF	Beryllium trifluoride ion	Be F3	7
ZN	Zinc ion	Zn	12
MG	Magnesium ion	Mg	14
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	13

Primary citation

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Saleh, A., Noguchi, Y., Aramayo, R. et al. Nat Commun (2022) 13:2915-2915. DOI 10.1038/s41467-022-30576-1 · PubMed

Other PDB entries of the same protein (UniProt P29469 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7W8G 2.52 Å, Cryo-EM structure of MCM double hexamer
28VY 2.7 Å, sCMGE assembled on ARS1 DNA with Sld2 and RPA
8RIF 2.79 Å, Cryo-EM structure of the MCM double hexamer loaded onto dsDNA.
7V3V 2.9 Å, Cryo-EM structure of MCM double hexamer bound with DDK in State I
9TH8 2.9 Å, Cryo-EM structure of MCM2-7 DH bound to Sld3-Sld7, Cdc45 and DNA
7P30 3.0 Å, 3.0 A resolution structure of a DNA-loaded MCM double hexamer
8KG6 3.07 Å, Yeast replisome in state I
9RHL 3.1 Å, Phospho-DH bound by Sld3-MBD on ARS1 DNA
7PMK 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
7PMN 3.2 Å, S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
7PT6 3.2 Å, Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III
7V3U 3.2 Å, Cryo-EM structure of MCM double hexamer with structured Mcm4-NSD

Browse structure collections

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