7QWQ: Signal recognition particle 19 kDa protein
Ternary complex of ribosome nascent chain with SRP and NAC. Determined by electron microscopy at 2.83 Å resolution. Released 16 Mar 2022.
- Method
- Electron microscopy
- Resolution
- 2.83 Å
- Organisms
- Homo sapiens, Oryctolagus cuniculus
- Chains
- 52
- Atoms
- 143,809
- Mol. weight
- 2747.36 kDa
- Ligands
- MG, ZN
- Released
- 16 Mar 2022
Explore 7QWQ in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7QWQ contains 353 α-helices and 305 β-strands across 48 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 7 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 7-10 | 4 | |
| α-helix | 42-48 | 7 | |
| β-strand | 72-74 | 3 | 96 |
| α-helix | 79-81 | 3 | |
| α-helix | 84-88 | 5 | |
| β-strand | 100-102 | 3 | 97 |
| α-helix | 103-106 | 4 | |
| β-strand | 110-112 | 3 | 96 |
| β-strand | 123-126 | 4 | 97 |
| β-strand | 128-129 | 2 | 96 |
| α-helix | 131-140 | 10 | |
| β-strand | 143-146 | 4 | 97 |
Chain A: 9 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 9-12 | 4 | |
| α-helix | 29-32 | 4 | |
| α-helix | 34-38 | 5 | |
| β-strand | 40-49 | 10 | 13 |
| β-strand | 58-62 | 5 | 13 |
| β-strand | 73-77 | 5 | 13 |
| β-strand | 79 | 1 | 14 |
| β-strand | 83 | 1 | 15 |
| β-strand | 87-91 | 5 | 13 |
| β-strand | 101-103 | 3 | 16 |
| α-helix | 108 | 1 | |
| β-strand | 112-114 | 3 | 16 |
| β-strand | 116 | 1 | 17 |
| β-strand | 126 | 1 | 17 |
| β-strand | 134-140 | 7 | 16 |
| α-helix | 142-144 | 3 | |
| β-strand | 145-149 | 5 | 16 |
| β-strand | 155-159 | 5 | 16 |
| β-strand | 163-166 | 4 | 16 |
| β-strand | 169 | 1 | 14 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-190 | 9 | |
| β-strand | 224-225 | 2 | 18 |
| α-helix | 229-230 | 2 | |
| β-strand | 237-238 | 2 | 18 |
Chain b: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-18 | 7 | |
| α-helix | 37-48 | 12 | |
| α-helix | 54-75 | 22 | |
Chain B: 17 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 9-10 | 2 | |
| α-helix | 14-16 | 3 | |
| α-helix | 32-35 | 4 | |
| α-helix | 40-41 | 2 | |
| β-strand | 42 | 1 | 25 |
| β-strand | 45-54 | 10 | 26 |
| β-strand | 57-59 | 3 | 27 |
| β-strand | 71-73 | 3 | 27 |
| β-strand | 76-80 | 5 | 26 |
| β-strand | 84-95 | 12 | 28 |
| β-strand | 98-106 | 9 | 28 |
| α-helix | 112-116 | 5 | |
| α-helix | 134-138 | 5 | |
| α-helix | 140-156 | 17 | |
| β-strand | 159-165 | 7 | 28 |
| α-helix | 168-170 | 3 | |
| β-strand | 180-185 | 6 | 28 |
| β-strand | 186 | 1 | 25 |
| α-helix | 190-199 | 10 | |
| β-strand | 204-205 | 2 | 28 |
| α-helix | 207-210 | 4 | |
| β-strand | 216-222 | 7 | 26 |
| α-helix | 223-224 | 2 | |
| β-strand | 225-229 | 5 | 29 |
| α-helix | 231-235 | 5 | |
| α-helix | 237-241 | 5 | |
| β-strand | 270-273 | 4 | 29 |
| β-strand | 276-288 | 13 | 26 |
| α-helix | 289-291 | 3 | |
| β-strand | 292-293 | 2 | 30 |
| β-strand | 297-298 | 2 | 30 |
| α-helix | 300-302 | 3 | |
| β-strand | 320 | 1 | 31 |
| β-strand | 324 | 1 | 31 |
| β-strand | 330-334 | 5 | 26 |
| β-strand | 344-349 | 6 | 26 |
| α-helix | 357-360 | 4 | |
| β-strand | 365-367 | 3 | 27 |
| α-helix | 382-389 | 8 | |
Chain c: 4 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 14-24 | 11 | |
| β-strand | 26-29 | 4 | 36 |
| α-helix | 31-39 | 9 | |
| β-strand | 45-48 | 4 | 36 |
| α-helix | 54-67 | 14 | |
| β-strand | 70-73 | 4 | 36 |
| α-helix | 78-84 | 7 | |
| β-strand | 93-98 | 6 | 36 |
Chain C: 24 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-9 | 3 | 37 |
| β-strand | 10-11 | 2 | 38 |
| β-strand | 12-13 | 2 | 39 |
| β-strand | 15 | 1 | 39 |
| β-strand | 21-23 | 3 | 37 |
| α-helix | 24-25 | 2 | |
| α-helix | 26-29 | 4 | |
| α-helix | 34-44 | 11 | |
| α-helix | 49-51 | 3 | |
| β-strand | 64-66 | 3 | 40 |
| β-strand | 77-79 | 3 | 40 |
| α-helix | 117-130 | 14 | |
| α-helix | 134-139 | 6 | |
| β-strand | 152-154 | 3 | 38 |
| α-helix | 156-160 | 5 | |
| α-helix | 164-173 | 10 | |
| α-helix | 177-185 | 9 | |
| β-strand | 188-189 | 2 | 41 |
| α-helix | 190 | 1 | |
| α-helix | 193-197 | 5 | |
| β-strand | 201-202 | 2 | 41 |
| β-strand | 208-211 | 4 | 38 |
| α-helix | 217-220 | 4 | |
| β-strand | 228-231 | 4 | 38 |
| α-helix | 232-234 | 3 | |
| α-helix | 237-240 | 4 | |
| α-helix | 242-244 | 3 | |
| β-strand | 250-253 | 4 | 38 |
| α-helix | 254-264 | 11 | |
| α-helix | 279-282 | 4 | |
| α-helix | 289-294 | 6 | |
| α-helix | 296-300 | 5 | |
| α-helix | 303-305 | 3 | |
| α-helix | 312-315 | 4 | |
| α-helix | 322-328 | 7 | |
| α-helix | 332-337 | 6 | |
| α-helix | 341-362 | 22 | |
Chain d: 4 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 22-28 | 7 | 45 |
| α-helix | 30-32 | 3 | |
| α-helix | 38-40 | 3 | |
| α-helix | 42-56 | 15 | |
| β-strand | 62-64 | 3 | 45 |
| α-helix | 66-73 | 8 | |
| β-strand | 83-91 | 9 | 45 |
| β-strand | 103-108 | 6 | 45 |
| β-strand | 121-122 | 2 | 45 |
Chain D: 18 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 10-14 | 5 | |
| α-helix | 21-25 | 5 | |
| α-helix | 30-36 | 7 | |
| α-helix | 38-40 | 3 | |
| β-strand | 50-55 | 6 | 48 |
| β-strand | 60-67 | 8 | 48 |
| β-strand | 72-79 | 8 | 48 |
| α-helix | 80-82 | 3 | |
| α-helix | 83-86 | 4 | |
| α-helix | 95-112 | 18 | |
| α-helix | 134-135 | 2 | |
| α-helix | 139-142 | 4 | |
| β-strand | 146-147 | 2 | 48 |
| α-helix | 158-169 | 12 | |
| β-strand | 183-184 | 2 | 49 |
| β-strand | 189-190 | 2 | 49 |
| α-helix | 194-200 | 7 | |
| α-helix | 202-214 | 13 | |
| α-helix | 216-222 | 7 | |
| α-helix | 224-227 | 4 | |
| α-helix | 233-235 | 3 | |
| α-helix | 236-249 | 14 | |
| α-helix | 268-272 | 5 | |
| α-helix | 273-291 | 19 | |
40 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Srp RNA 7SL | 1 | RNA | 167 | Homo sapiens | |
| Signal recognition particle 19 kDa protein | q | protein | 144 | Homo sapiens | P09132 (AlphaFold model) |
| Nascent chain preprolactin | s | protein | 112 | Homo sapiens | |
| Isoform 2 of Transcription factor BTF3 | u | protein | 162 | Homo sapiens | P20290 (AlphaFold model) |
| Signal recognition particle subunit SRP68 | v | protein | 627 | Homo sapiens | Q9UHB9 (AlphaFold model) |
| Signal recognition particle 54 kDa protein | x | protein | 504 | Homo sapiens | P61011 (AlphaFold model) |
| L8 | A | protein | 244 | Oryctolagus cuniculus | G1TT27 |
| 60S ribosomal protein L29 | b | protein | 223 | Oryctolagus cuniculus | G1SGR6 |
| 28S rRNA | 5 | RNA | 4754 | Oryctolagus cuniculus | |
| uL3 | B | protein | 403 | Homo sapiens | G1TL06 |
| 60S ribosomal protein L30 | c | protein | 115 | Oryctolagus cuniculus | G1TDL2 |
| 60S ribosomal protein L4 | C | protein | 413 | Oryctolagus cuniculus | G1SVW5 |
40 more molecules are not listed.
Sequence of entity 1 (1), FASTA
>7QWQ_1 SRP RNA 7SL (chains 1)
CGCUAUGCCGAUCGGGUGUCCGCACUAAGUUCGGCAUCAAUAUGGUGACCUCCCGGGAGC
GGGGGACCACCAGGUUGCCUAAGGAGGGGUGAACCGGCCCAGGUCGGAAACGGAGCAGGU
CAAAACUCCCGUGCUGAUCAGUAGUGGGAUCGCGCCUGUGAAUAGCC
Sequence of entity 2 (q), FASTA
>7QWQ_2 Signal recognition particle 19 kDa protein (chains q)
MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNV
FLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQ
KTGGADQSLQQGEGSKKGKGKKKK
Sequence of entity 3 (s), FASTA
>7QWQ_3 Nascent chain preprolactin (chains s)
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Sequence of entity 4 (u), FASTA
>7QWQ_4 Isoform 2 of Transcription factor BTF3 (chains u)
MKETIMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIE
EVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRR
LAEALPKQSVDGKAPLATGEDDDDEVPDLVENFDEASKNEAN
Sequence of entity 5 (v), FASTA
>7QWQ_5 Signal recognition particle subunit SRP68 (chains v)
MAAEKQVPGGGGGGGSGGGGGSGGGGSGGGRGAGGEENKENERPSAGSKANKEFGDSLSL
EILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTD
NRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDA
KTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAFTEEQAVLYNQRVEEI
SPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRG
RTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQK
QRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQPEDDSKRSPR
PQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWS
EALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDAHQ
TETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAF
PPLEDKLEQKTKSGLTGYIKGIFGFRS
Sequence of entity 6 (x), FASTA
>7QWQ_6 Signal recognition particle 54 kDa protein (chains x)
MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAI
DLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSK
LAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFK
NENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIEQACEAQAKAFKDKV
DVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDI
EGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFM
SKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQEL
LTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGL
QSMMRQFQQGAAGNMKGMMGFNNM
Sequence of entity 7 (A), FASTA
>7QWQ_7 L8 (chains A)
GRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKV
VFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPG
DRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILK
AGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAAR
RTGR
Sequence of entity 8 (b), FASTA
>7QWQ_8 60S ribosomal protein L29 (chains b)
MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQAN
NAKAMAARAEAIKALVKPKEVKPTIPKGVSRKLDRLAYIAHPKLGRRARARIARGLRLSR
PQTKAKAKTEPQIKGKVKAQIKAQAQAQIKSKGKGKAQAETKPKAQAQAKPKAQAQGKPK
AQAQAKPKAHAQAKPKAQAQAKPKAQAQTKRTGVTPGLLSAWG
Sequence of entity 9 (5), FASTA
>7QWQ_9 28S rRNA (chains 5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAG
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGCGGGGCGCGGGACAUGUGGCGUACGGAAGACCCGCUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GGGUCCGGCCGUGUCGGCGGUCUCGGCGGAUCUUUCCCGCUCCCCGUUCCUCCCGACCCC
UCCACCCGCUCCCCCUCCCCCGCCGGUCUUCUCCCUUCACGGGGGGUGGGUCGGCGGGUG
CGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGUCCCCCGACCGGCGA
CCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCGGGACGGC
UGGGAAGGCCCGGCGGGGAAGGUGGCUCGGGGGGACGCCUCGCCGCCGUCGUCCGCGGCG
GCGGCGGGCGCGACCCCUCCCCGAGUGUUACAGCCCCCCCGGCAGCAGCACUCGCCGAAU
CCCGGGGCCGAGGGAGCGAGACCCGUCGCCGCGCUCUCCCCCCUCCCGGCGCUCCCCCCC
GCGGGGGUCCCCCGCGAGGGGGCUCCCCCCGCGGGGGCGCGCCGGUGUCGCCGCCCUCGC
GGGCGCGGCACGGGGGGGCCGGGCCACCCCUCCCACGGCGCGACCGCUCUCCCGGCCCCC
GCCGCCGCCUCUUCGGGCGUGCGGCGGGGGCGGGGCGGACUGUCCCCAGUGCGCCCCGGG
CGGGUCGCGCCGUCGGGCCCGGGGGAGAAGUCGGCCACGGGGCCACGCGCGCCUCCGCGU
CCCCCCCUCGCCGUCUCCGGGCGGCGGGGGGGGGUUUCGGCGCGGUGUUCUCGGCGCGCG
CGCGCGAGCGAGCGCACGGGGUCGGCGGCGACGUCGGCUACCCACCCGACCCGUCUUGAA
ACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCCGCCGUGG
CGCAAUGAAGGUGAAGGCCGGCGCGCUCGCCGGCCGAGGUGGGAUCCCGAGGCCUCUCCA
GUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGCCGGGGAGGUGGAGCACGA
GCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGGCAGGGCGAAGCCAGAGGA
AACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGGUCGUCCGACCUGGGUAUA
GGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUCCGAAGUUUCCCUCAGGAU
AGCUGGCGCUCUCGCAACCACGCAGUUUUAUCCGGUAAAGCGAAUGAUUAGAGGUCUUGG
GGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGUAAGAAGCCCGGCUCGCUGG
CGUGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACUUUUGGUAAGCAGAACUGGCG
CUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGCCGACGCUCAUCAGACCCCAG
AAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAAG
GAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGAAAAUGGAUGGCGCUGGAGCG
UCGGGCCCAUACCCGGCCGUCGCCGGCAGUCGAGAGUGGACGGGAGCGCGGGACUCCCCC
CGCGGGGGUCCCCCGCCCCCGGAGCCCCGCGGACGCUACGCCGCGACGAGUAGGAGGGCC
GCUGCGGUGAGCCUUGAAGCCUAGGGCGCGGGCCCGGGUGGAGCCGCCGCAGGUGCAGAU
CUUGGUGGUAGUAGCAAAUAUUCAAACGAGAACUUUGAAGGCCGAAGUGGAGAAGGGUUC
CAUGUGAACAGCAGUUGAACAUGGGUCAGUCGGUCCUGAGAGAUGGGCGAGCGCCGUUCC
GAAGGGACGGGCGAUGGCCUCCGUUGCCCUCGGCCGAUCGAAAGGGAGUCGGGUUCAGAU
CCCCGAAUCCGGAGUGGCGGAGAUGGGCGCCGCGAGGCGUCCAGUGCGGUAACGCGACCG
AUCCCGGAGAAGCCGGCGGGAGCCCCGGGGAGAGUUCUCUUUUCUUUGUGAAGGGCAGGG
CGCCCUGGAAUGGGUUCGCCCCGAGAGAGGGGCCCGUGCCUUGGAAAGCGUCGCGGUUCC
GGCGGCGUCCGGUGAGCUCUCGCUGGCCCUUGAAAAUCCGGGGGAGAGGGUGUAAAUCUC
GCGCCGGGCCGUACCCAUAUCCGCAGCAGGUCUCCAAGGUGAACAGCCUCUGGCAUGUUG
GAACAAUGUAGGUAAGGGAAGUCGGCAAGCCGGAUCCGUAACUUCGGGAUAAGGAUUGGC
UCUAAGGGCUGGGUCGGUCGGGCUGGGGCGCGAAGCGGGGCUGGGCGCGCGCCGCGGCUG
GACGAGGCGCCGCCGCCCCCCCCACGCCCGGGGCGCCCUCCCCCGGCCGGGUCCGCUCCC
UCGCGCGCGCGUGCGCCGUGGCGCGCGCCGCGCGCGCGGCCGAGCCCCGUCUCCCUCCCC
CCCUCUCCCCUCCCGGGGCGGGGUGCGGGGAGGGGCGGGCGGGGCCGUCGCUCGCCGCGC
GUGCGCGUCGCUGCGCGUGCGCCGCGCGGGGGGUCCGGCGGGCCUCCGGACGGGGGCUCC
GGGCACCCGGGCACCCGGGGGGCCGGCGGCGGCGGCGACUCUGGACGCGAGCCGGGCCCU
UCCCGUGGAUCGCCCCAGCUGCGGCGGGCGUCGCGGCCGCCCUCGGGGAGCCCGGCGGGC
GCCGCGUGCGCGCGCGUGCGCGCCCGGGGUCGGGGGGGUGCGAGGCAGGGGAGGCCCUCU
CUCCUCCUCCCCCACCCCGGCGCCGCGGCGCCGCGCGUGCGCGCGCGGUCUCCCCCCGCC
GGGUCCGCCCCCGGGGCCGCGGUUCCGCGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAGC
CGACUUAGAACUGGUGCGGACCAGGGGAAUCCGACUGUUUAAUUAAAACAAAGCAUCGCG
AAGGCCCGCGGCGGGUGUUGACGCGAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGU
GAAGAAAUUCAAUGAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGC
CAAAUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUGAACGAGAUUCCCACUGUC
CCUACCUACUAUCCAGCGAAACCACAGCCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGA
AAGAAGACCCUGUUGAGCUUGACUCUAGUCUGGCACGGUGAAGAGACAUGAGAGGUGUAG
AAUAAGUGGGAGGCCCCCGGCGCCCUCCCGCCCCCGCGAGGGGGCGGGGCGGGGUCCGCC
GGCCUUGCGGGCCGCCGGUGAAAUACCACUACUCUUAUCGUUUUUUCACUGACCCGGUGA
GGCGGGGGGGCGAGCCCCGAGGGGCUCUCGCUUCUGGCGCCAAGCGCCCGGCCGCGCGCC
GGCCGGGCGCGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUACA
CCUGUCAAACGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGU
GGAGCAGAAGGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGAAA
GCGGGGCCUCACGAUCCUUCUGACCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGUUA
CCACAGGGAUAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCU
UCGAUGUCGGCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACC
CACUAAUAGGGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUAC
UGAUGAUGUGUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGAC
AUUUGGUGUAUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUUAU
GACUGAACGCCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCGCGGAG
CCUCGGUUGGCCUCGGAUAGCCGGUCCCCCGCCGUCCCCGCCGGCGGCCCGCGUCGUGCG
UCCGCCUCGGCGGCGUGCGGCGCGCCCCCCGCCGCGCGUCGGGACCGGGGUCCGGUGCGG
AGUGCCCUUCGUCCUGGGAAACGGGGCGCGGCCGGAGAGGCGGCCGCCCCCUCGCCCGUC
ACGCACGCCGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGACGACCUGCUUCUGGGU
CGGGGUUUCGUACGUAGCAGAGCAGCUCCCUCGCUGCGAUCUAUUGAAAGUCAGCCCUCG
ACACAAGGGUUUGU
Sequence of entity 10 (B), FASTA
>7QWQ_10 uL3 (chains B)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 11 (c), FASTA
>7QWQ_11 60S ribosomal protein L30 (chains c)
MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEI
EYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLSIIDPGDSDIIRSMPEQTGEK
Sequence of entity 12 (C), FASTA
>7QWQ_12 60S ribosomal protein L4 (chains C)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKL
APGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAA
KSDPKEAPAKKKPVVGKKKKPVVGRKAAAAKKPAADKKAADKRAGPEDKKPAA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 97 |
| ZN | Zinc ion | Zn | 5 |
Primary citation
Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Jomaa, A., Gamerdinger, M., Hsieh, H.H. et al. Science (2022) 375:839-844. DOI 10.1126/science.abl6459 · PubMed
Other PDB entries of the same protein (UniProt P09132 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1JID 1.8 Å, Human SRP19 in complex with helix 6 of Human SRP RNA
- 1MFQ 3.1 Å, Crystal Structure Analysis of a Ternary S-Domain Complex of Human Signal Recognition…
- 7NFX 3.2 Å, Mammalian ribosome nascent chain complex with SRP and SRP receptor in early state A
- 5M73 3.4 Å, Structure of the human SRP S domain with SRP72 RNA-binding domain
- 4P3E 3.5 Å, Structure of the human SRP S domain
- 3KTV 3.8 Å, Crystal structure of the human SRP19/S-domain SRP RNA complex
- 2J37 8.7 Å, Model of mammalian srp bound to 80S rncs
- 1RY1 12.0 Å, Structure of the signal recognition particle interacting with the elongation-arrested…
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