7Z73: P63 tetramerization domain

Crystal structure of p63 tetramerization domain in complex with darpin 8F1. Determined by X-ray diffraction at 2.27 Å resolution. Released 6 Jul 2022.

Method: X-ray diffraction
Resolution: 2.27 Å
Organisms: Homo sapiens, synthetic construct
Chains: 6
Atoms: 3,565
Mol. weight: 56.65 kDa
Released: 6 Jul 2022

Explore 7Z73 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7Z73 contains 24 α-helices and 4 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 2 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	361-367	7	1
α-helix	369-385	17
α-helix	390-404	15

Chain C: 2 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	361-367	7	2
α-helix	369-385	17
α-helix	390-401	12

Chain D: 2 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	361-367	7	2
α-helix	369-386	18
α-helix	390-401	12

Chain E: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	4-14	11
α-helix	17-25	9
α-helix	40-47	8
α-helix	50-58	9
α-helix	73-79	7
α-helix	83-91	9
α-helix	106-112	7
α-helix	116-125	10

Chain F: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	3-14	12
α-helix	17-25	9
α-helix	40-47	8
α-helix	50-58	9
α-helix	73-79	7
α-helix	83-91	9
α-helix	106-112	7
α-helix	116-125	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Isoform 2 of Tumor protein 63	A, B, C, D	protein	61	Homo sapiens	Q9H3D4 (AlphaFold model)
Darpin 8F1	E, F	protein	126	synthetic construct

Sequence of entity 1 (A, B, C, D), FASTA

>7Z73_1 Isoform 2 of Tumor protein 63 (chains A, B, C, D)
GSDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQ
S

Sequence of entity 2 (E, F), FASTA

>7Z73_2 Darpin 8F1 (chains E, F)
GSDLGKKLLEAARAGQDDEVRILMANGADVNAADWLGYTPLHLAAWYGHLEIVEVLLKTG
ADVNARDAYGITPLHLAAYYGHLEIVEVLLKHGADVNAQDKFGKTPFDLAIDNGNEDIAE
VLQKAA

Primary citation

Designed Ankyrin Repeat Proteins as a tool box for analyzing p63. Strubel, A., Munick, P., Chaikuad, A. et al. Cell Death Differ (2022) 29:2445-2458. DOI 10.1038/s41418-022-01030-y · PubMed

Other PDB entries of the same protein (UniProt Q9H3D4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2Y9U 1.6 Å, Structural basis of p63a SAM domain mutants involved in AEC syndrome
8P9C 1.76 Å, Crystal structure of p63-p73 heterotetramer (tetramerisation domain) in complex with…
7Z72 1.8 Å, Crystal structure of p63 SAM in complex with darpin A5
7Z7E 1.8 Å, Crystal structure of p63 DNA binding domain in complex with inhibitory DARPin G4
7Z71 1.85 Å, Crystal structure of p63 DBD in complex with darpin C14
3ZY0 1.9 Å, Crystal structure of a truncated variant of the human p63 tetramerization domain lacking…
6RU8 1.92 Å, Crystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated…
6RU6 2.05 Å, Crystal structure of Casein Kinase I delta (CK1d) in complex with monophosphorylated p63…
6RU7 2.08 Å, Crystal structure of Casein Kinase I delta (CK1d) in complex with double phosphorylated…
3ZY1 2.15 Å, Crystal structure of the human p63 tetramerization domain
9N54 2.2 Å, Bipartite p63 NLS in complex with Importin Alpha 2
8P9E 2.25 Å, Crystal structure of wild type p63-p73 heterotetramer (tetramerisation domain) in…

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