8A9Q: Albumin

Computational design of stable mammalian serum albumins for bacterial expression. Determined by X-ray diffraction at 2.0 Å resolution. Released 10 May 2023.

Method

X-ray diffraction

Resolution

2.0 Å

Organism

Escherichia coli

Chains

2

Atoms

9,165

Mol. weight

135.87 kDa

Ligands

DAO, RWF, MYR

Released

10 May 2023

Explore 8A9Q in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8A9Q contains 80 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 39 helices, 0 β-strands

Molecules and chains

>8A9Q_1 Albumin (chains A, B)
DAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDLVKMVNEVTEFAKTCVADESAE
NCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEP
DVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLYFAKRYKAAFTECCQAADKAACLLP
KLDELREEGKASSAKQRHKCAILQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTK
VHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPA
DLPSLAADFIESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKC
CAAADPHECYSKVFDEFKPLIEEPQNLIKQNCELFEQLGEYKFQNALLIRYTKKVPQVST
PTLVEVARNLGKVGSKCCKHPEAKRMPCAEDYLSIVLNQLCVLHEKTPVSDRVTKCCTES
LVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEEERQIKKQTALVELVKHKPKAT
KEQLKAVMDDFSAFVEKCCKADDKETCFAEEGKKLIAASQAALGL

Ligands and cofactors

Primary citation

Stable Mammalian Serum Albumins Designed for Bacterial Expression. Khersonsky, O., Goldsmith, M., Zaretsky, I. et al. J Mol Biol (2023) 435:168191-168191. DOI 10.1016/j.jmb.2023.168191 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P02768 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 9IK6 1.69 Å, Human Serum Albumin crystallized with T4, pH 6.5
• 6YG9 1.89 Å, Crystal structure of human serum albumin (HSA) in complex with gn-07.
• 1N5U 1.9 Å, X-ray study of human serum albumin complexed with heme
• 8RCO 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution
• 8RCP 1.9 Å, Structure of Human Serum Albumin in complex with Myristic Acid
• 8RGK 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution
• 8RGL 1.9 Å, Structure of Human Serum Albumin in complex with Aristolochic Acid I at 1.9 A resolution…
• 9EOD 1.9 Å, Human serum albumin with adamantene carboxylic acid
• 9CSG 1.91 Å, Human Serum Albumin Bound to Cerastecin Compound 5e
• 6QIO 1.95 Å, Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the…
• 9IK7 1.97 Å, Human Serum Albumin crystallized with T4, pH 7.5
• 7VR0 1.98 Å, Human Serum Albumin

Browse structure collections

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