8ATM: Giant inhibitor of apoptosis, BIRC6

Structure of the giant inhibitor of apoptosis, BIRC6 (composite map). Determined by electron microscopy at 3.3 Å resolution. Released 8 Mar 2023.

Method
Electron microscopy
Resolution
3.3 Å
Organism
Homo sapiens
Chains
2
Atoms
30,885
Mol. weight
1061.95 kDa
Released
8 Mar 2023

Explore 8ATM in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8ATM contains 213 α-helices and 85 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 103 helices, 45 β-strands

ElementResiduesLengthSheet
α-helix1314-132310
α-helix1326-133611
α-helix1346-136318
α-helix1379-13813
α-helix1385-13928
α-helix1398-141215
α-helix1424-143512
α-helix1436-14416
α-helix1445-145814
α-helix1464-148219
α-helix1487-14959
β-strand1511-151221
β-strand1515-151621
β-strand1521-152222
β-strand1526-152942
β-strand1777-177933
β-strand1789-1806182
β-strand1812-182092
β-strand1829-183462
β-strand1842-184432
α-helix1850-18512
β-strand1852-1862112
β-strand1872-187433
β-strand1877-188152
α-helix1912-193928
α-helix1950-19578
α-helix1961-199838
α-helix2020-203920
α-helix2049-20535
α-helix2059-20668
α-helix2072-208615
α-helix2094-210411
α-helix2114-212714
α-helix2133-214513
α-helix2165-218218
α-helix2325-234016
β-strand234714
α-helix2348-236417
α-helix2368-23703
α-helix2371-23744
α-helix2377-238812
β-strand238915
β-strand239416
β-strand239716
α-helix2402-241918
α-helix2576-259924
α-helix2636-264813
β-strand265515
α-helix2657-266812
α-helix2698-271013
α-helix2716-273116
α-helix2745-27473
α-helix2748-27536
α-helix2756-276712
β-strand277717
α-helix2783-280119
α-helix2805-282016
α-helix2825-28284
α-helix2833-284311
β-strand285218
α-helix2854-287219
β-strand2877-287939
β-strand2891-2892210
α-helix2915-292915
α-helix29321
β-strand2933111
β-strand2934112
β-strand294018
β-strand2941112
β-strand2979111
α-helix2980-29856
α-helix2988-299912
β-strand3002-3003210
α-helix3006-30083
α-helix3032-304514
α-helix3050-306112
α-helix3065-30673
α-helix3079-308810
α-helix3092-31009
α-helix3103-311614
β-strand3120113
α-helix3125-31328
β-strand3161-316229
α-helix3164-31663
β-strand3168-317149
α-helix3180-31834
α-helix3187-31893
β-strand3197-320049
β-strand3207-3227219
α-helix3232-32343
β-strand3238-324479
β-strand3251-325229
α-helix32561
β-strand3257-325829
β-strand3265-3283199
α-helix3284-32852
β-strand3290-3301129
α-helix3329-333911
α-helix3345-33528
α-helix3358-33669
α-helix3375-338612
α-helix3391-340111
α-helix34061
α-helix3429-343911
α-helix3446-346318
α-helix3491-350616
α-helix3513-35164
α-helix3519-353012
α-helix3537-355216
α-helix3554-356411
α-helix3607-361610
α-helix3622-36276
α-helix3632-364413
α-helix3680-369314
α-helix3697-37037
α-helix3709-371911
α-helix3753-377018
α-helix3775-379016
α-helix3807-38159
β-strand3821-3827714
α-helix3847-38493
β-strand3855-3861714
β-strand3865115
α-helix3866-38738
β-strand3965-3968414
α-helix3976-39783
β-strand3982115
α-helix3983-399210
α-helix3995-39962
β-strand4002-4008714
α-helix4064-40696
α-helix4070-40767
α-helix4080-40867
α-helix4155-416410
α-helix4170-41745
α-helix4178-418811
β-strand4193116
β-strand4199116
α-helix4200-42023
α-helix4212-422312
α-helix4229-424113
α-helix4243-425513
α-helix4306-433126
α-helix4369-437810
α-helix4389-440416
α-helix4406-44116
α-helix4433-445018
α-helix4483-450018
Chain B: 110 helices, 40 β-strands
ElementResiduesLengthSheet
α-helix1385-13939
α-helix1398-141215
α-helix1424-143613
α-helix1439-14413
α-helix1445-14473
α-helix1449-145810
α-helix1459-14613
α-helix1465-148218
α-helix1487-14915
α-helix1492-14965
α-helix15211
β-strand1522117
α-helix15231
α-helix1772-17743
β-strand1789-18051717
β-strand1814-1820717
β-strand1829-1834617
β-strand1843-1844217
α-helix1850-18512
β-strand1852-18611017
β-strand1877-1881517
α-helix1913-193927
α-helix1950-19578
α-helix1961-199737
α-helix2015-20173
α-helix2020-204021
α-helix2049-20535
α-helix2059-20668
α-helix2072-208514
α-helix2094-210310
α-helix2114-212815
α-helix2129-21313
α-helix2133-214513
α-helix2165-218218
α-helix2325-233915
β-strand2347113
α-helix2348-236417
α-helix2368-23703
α-helix2371-23744
α-helix2377-238812
β-strand2389118
β-strand2394119
β-strand2397119
α-helix2401-241919
α-helix2577-259923
α-helix2636-264813
β-strand2655118
α-helix2657-266812
α-helix2698-271013
α-helix2716-273116
α-helix2745-27473
α-helix2748-27536
α-helix2756-276712
β-strand277719
α-helix2783-280119
α-helix2805-282016
α-helix2825-28284
α-helix2833-284311
β-strand2852120
α-helix2854-287219
β-strand2877-287937
β-strand2892121
α-helix2915-292915
α-helix29321
β-strand2933122
β-strand2934123
β-strand2940120
β-strand2941123
β-strand2979122
α-helix2980-29856
α-helix2988-299912
β-strand3003121
α-helix3005-30073
α-helix3032-304514
α-helix3050-306112
α-helix3065-30673
α-helix3079-308810
α-helix3092-31009
α-helix3103-311614
β-strand312014
α-helix3125-31306
β-strand3161-316227
α-helix3164-31663
β-strand3168-317147
α-helix3180-31834
α-helix3187-31893
β-strand3197-320047
β-strand3207-3227217
α-helix3232-32343
β-strand3238-324477
β-strand3251-325227
α-helix32561
β-strand3257-325827
β-strand3265-3283197
α-helix3284-32852
β-strand3290-3301127
α-helix3322-33254
α-helix3328-333912
α-helix3342-33443
α-helix3345-33528
α-helix3358-33669
α-helix3375-338612
α-helix3391-340111
α-helix34061
α-helix3429-344012
α-helix3446-346419
α-helix3491-350616
α-helix3513-35164
α-helix3519-353113
α-helix35331
α-helix3537-355216
α-helix3554-356411
α-helix3607-361610
α-helix3620-36278
α-helix3632-364413
α-helix3680-369314
α-helix3697-37037
α-helix3709-371911
α-helix3753-377018
α-helix3775-379016
α-helix3807-38159
β-strand3821-3827724
α-helix3847-38493
β-strand3855-3861724
β-strand3865125
α-helix3866-38738
β-strand3965-3968424
α-helix3976-39783
β-strand3982125
α-helix3983-399210
α-helix3995-39962
β-strand4002-4008724
α-helix4064-40696
α-helix4070-40767
α-helix4079-40857
α-helix4155-416410
α-helix4170-41745
α-helix4178-418811
β-strand4193126
β-strand4199126
α-helix4200-42023
α-helix4212-422312
α-helix4229-424113
α-helix4243-425412
α-helix4306-433126
α-helix4369-43779
α-helix4389-440416
α-helix4409-44113
α-helix4433-445018
α-helix4483-450018

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Baculoviral IAP repeat-containing protein 6A, Bprotein4859Homo sapiensQ9NR09
Sequence of entity 1 (A, B), FASTA
>8ATM_1 Baculoviral IAP repeat-containing protein 6 (chains A, B)
GPMVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVL
RDGCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQ
YISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACL
EKVDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNE
LKKINQNVAALPVASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPH
VGYRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFV
KGEHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLM
KVHLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLE
DSDSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEEL
GANPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQ
GESISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLH
DDGFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQ
CLRLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCN
RRKGELESNLAVVNGANISVIQHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVT
LEEEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDIS
TLGHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKG
GELHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFT
LEILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWK
LQTDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNAL
NIEVEQNGKPSLVDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHA
GMLTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYS
LASLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQR
CAMLQFSEFHEKLLNTLCRKTDDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLL
SKTRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSF
LPAATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGL
YSSPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEGSFTSLT
GLLEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQ
SLSHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPS
NPVAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAV
NLAAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRP
ILLTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKI
TVIGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKGEGESANQPEIDQHLAMMV
ALQEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCI
QLQLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLL
HASNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSN
VLQELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRR
TEGVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSK
GSSSLDRLYSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKL
KQATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLF
LLSMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDIS
WGGAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLE
TIDEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISS
TWYDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQ
AELMLKMMSTLEADSILQALTNTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPM
LNVCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQ
ASITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNL
IHVLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHI
LSTERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVM
SRSGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNR
EYSARVSVTTNTTDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSAL
GLCNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPIL
TYMACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAI
VNTARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQP
AEVLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSS
VSVEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKL
LGLTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANL
LQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPL
LFGRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPN
SSTVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVL
KKAVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKN
AQAPLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSID
ISQDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFL
LCHSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQ
KLMAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRIN
ATSHVIQHPMYGAGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEE
KEKVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANK
IITVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSL
SKTDSYKRLHPEKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMG
GLALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAA
EPPPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGS
HILQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHS
PRVPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEE
HVTCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLR
NDSVLDMARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLA
KMKTCVDTYTNRLRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQA
NQEKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYH
YMSQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPAD
TPYANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPE
EKWNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKW
AMLEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALK
RHTAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL

Primary citation

Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Dietz, L., Ellison, C.J., Riechmann, C. et al. Science (2023) 379:1112-1117. DOI 10.1126/science.ade8840 · PubMed

Other PDB entries of the same protein (UniProt Q9NR09), best resolution first:

Browse structure collections

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