9XGB: UBA6-BIRC6 ubc-ubt

UBA6-BIRC6 ubc-ubt. Determined by electron microscopy at 3.3 Å resolution. Released 15 Jul 2026.

Method: Electron microscopy
Resolution: 3.3 Å
Organism: Homo sapiens
Chains: 3
Atoms: 10,786
Mol. weight: 164.96 kDa
Released: 15 Jul 2026

Explore 9XGB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9XGB contains 75 α-helices and 70 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 56 helices, 50 β-strands

Element	Residues	Length	Sheet
α-helix	48-51	4
α-helix	53-59	7
β-strand	63-67	5	8
α-helix	71-83	13
β-strand	87-91	5	8
α-helix	94	1
β-strand	95	1	9
α-helix	96	1
α-helix	98-102	5
α-helix	109-114	6
β-strand	117	1	9
α-helix	118-127	10
β-strand	134-138	5	8
α-helix	140-142	3
α-helix	149-153	5
β-strand	156-160	5	8
α-helix	164-175	12
α-helix	180-181	2
β-strand	182-189	8	8
β-strand	190	1	10
β-strand	192-198	7	8
β-strand	202-205	4	11
β-strand	207	1	12
α-helix	211-214	4
β-strand	215-217	3	13
β-strand	218-221	4	14
β-strand	227-231	5	14
β-strand	244-250	7	13
α-helix	254-256	3
β-strand	260-262	3	13
β-strand	264-265	2	14
β-strand	270-273	4	14
α-helix	280-282	3
β-strand	285-290	6	13
α-helix	291-292	2
β-strand	295-298	4	11
α-helix	302-307	6
β-strand	311	1	8
α-helix	312-313	2
α-helix	321-339	19
α-helix	342-344	3
α-helix	348-364	17
α-helix	373-381	9
β-strand	386	1	10
α-helix	388-407	20
β-strand	409	1	12
β-strand	416-417	2	8
β-strand	420	1	8
α-helix	422-425	4
α-helix	426-428	3
α-helix	434-436	3
α-helix	444-450	7
α-helix	452-459	8
β-strand	462-466	5	15
α-helix	470-482	13
β-strand	492-496	5	15
β-strand	500	1	16
α-helix	504-507	4
α-helix	514-516	3
β-strand	520	1	16
α-helix	521-532	12
β-strand	538-541	4	15
α-helix	548-550	3
α-helix	555-560	6
β-strand	563-566	4	15
α-helix	571-583	13
β-strand	588-594	7	15
β-strand	597-603	7	15
β-strand	608	1	17
α-helix	616-619	4
α-helix	624-629	6
α-helix	634-646	13
α-helix	647-651	5
α-helix	652-662	11
α-helix	666-674	9
α-helix	682-690	9
α-helix	696-711	16
α-helix	713-721	9
β-strand	727	1	18
β-strand	733	1	18
α-helix	752-768	17
α-helix	776-778	3
α-helix	780-787	8
α-helix	792-795	4
α-helix	820-833	14
α-helix	858-872	15
α-helix	875-877	3
α-helix	880-888	9
α-helix	895-913	19
β-strand	922-927	6	15
β-strand	932-937	6	15
β-strand	940	1	17
β-strand	944-947	4	19
β-strand	950-952	3	19
β-strand	958-961	4	20
β-strand	967	1	21
α-helix	968-978	11
β-strand	983-988	6	4
β-strand	991-994	4	4
α-helix	1001-1004	4
β-strand	1008	1	21
α-helix	1009-1013	5
β-strand	1021-1024	4	20
β-strand	1025-1028	4	4
β-strand	1038	1	4
β-strand	1043-1046	4	20

Chain B: 16 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	4525-4534	10
β-strand	4537-4540	4	1
β-strand	4543-4545	3	2
β-strand	4551-4553	3	2
α-helix	4560-4564	5
α-helix	4572-4587	16
β-strand	4591	1	3
β-strand	4596	1	3
β-strand	4597-4602	6	1
β-strand	4605	1	4
β-strand	4608-4613	6	1
α-helix	4614-4616	3
β-strand	4626-4631	6	1
α-helix	4640-4641	2
β-strand	4642-4645	4	1
β-strand	4659	1	5
β-strand	4664	1	1
β-strand	4665	1	5
α-helix	4688-4694	7
α-helix	4695-4699	5
α-helix	4704-4707	4
α-helix	4718-4734	17
α-helix	4735-4742	8
α-helix	4743-4745	3
α-helix	4749-4751	3
α-helix	4752-4761	10
α-helix	4765-4779	15
α-helix	4787-4810	24
α-helix	4811-4814	4

Chain C: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	6
β-strand	12-16	5	6
β-strand	22	1	7
α-helix	23-34	12
α-helix	38-40	3
β-strand	42-44	3	6
β-strand	49	1	6
α-helix	50-51	2
β-strand	55	1	7
β-strand	66-70	5	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6	B	protein	338	Homo sapiens	Q9NR09
Ubiquitin	C	protein	76	Homo sapiens	P62979 (AlphaFold model)
Ubiquitin-like modifier-activating enzyme 6	A	protein	1052	Homo sapiens	A0AVT1 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>9XGB_1 Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (chains B)
VLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYMSQVKNANDANSAARARRLA
QEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSS
PPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLI
LVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIRNPSPCFKEVIHKHF
YLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLREELLKLPCPEGLDP
DTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL

Sequence of entity 2 (C), FASTA

>9XGB_2 Ubiquitin (chains C)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGG

Sequence of entity 3 (A), FASTA

>9XGB_3 Ubiquitin-like modifier-activating enzyme 6 (chains A)
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA
KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE
AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP
IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE
TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE
SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS
ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE
AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA
LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA
HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT
EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW
QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH
CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA
DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS
DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT
VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV
HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK
YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD

Primary citation

UBA6-BIRC6 UBC-UbT. Tong, Z.T., Ai, H.S. To be published.

Other PDB entries of the same protein (UniProt Q9NR09), best resolution first:

8E2E 1.98 Å, Cryo-EM structure of helical arch of BIRC6 (from local refinement 1)
3CEG 2.01 Å, Crystal structure of the UBC domain of baculoviral IAP repeat-containing protein 6
8E2D 2.07 Å, Cryo-EM structure of BIRC6 (consensus)
8E2H 2.3 Å, Cryo-EM structure of C-terminal arm of BIRC6 (from local refinement 4)
8E2F 2.47 Å, Cryo-EM structure of N-terminal arm of BIRC6 (from local refinement 2)
8E2G 2.99 Å, Cryo-EM structure of N-terminal arm (aa68-966) of BIRC6 (from local refinement 3)
8ATO 3.0 Å, Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC
8E2I 3.04 Å, Cryo-EM structure of BIRC6/Smac
9QH5 3.09 Å, Consensus structure of UBA6-UbDha-BIRC6 trapped ternary complex (doubly loaded)
8E2K 3.21 Å, Cryo-EM structure of BIRC6/HtrA2-S306A
8ATM 3.3 Å, Structure of the giant inhibitor of apoptosis, BIRC6 (composite map)
8ATU 3.3 Å, Cryo-EM structure of human BIRC6

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