8E2D: BIRC6

Cryo-EM structure of BIRC6 (consensus). Determined by electron microscopy at 2.07 Å resolution. Released 15 Feb 2023.

Method
Electron microscopy
Resolution
2.07 Å
Organism
Homo sapiens
Chains
2
Atoms
30,898
Mol. weight
1068.32 kDa
Released
15 Feb 2023

Explore 8E2D in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8E2D contains 229 α-helices and 104 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 115 helices, 52 β-strands

ElementResiduesLengthSheet
α-helix1019-102911
β-strand1031-103331
α-helix1037-10382
β-strand1039-104132
β-strand1046-104831
α-helix1051-10544
α-helix1063-10664
α-helix1070-10723
β-strand1074-107961
α-helix10801
β-strand1089-109462
β-strand1101-110991
β-strand1120-112672
α-helix1172-11765
β-strand1181-118772
α-helix1188-11914
β-strand119211
β-strand1199-120351
α-helix1206-12094
β-strand1219-122682
α-helix1292-12954
β-strand1298-130691
α-helix13071
α-helix1314-132310
α-helix1325-133511
α-helix1340-13423
α-helix1346-136318
α-helix1377-13837
α-helix1385-139410
α-helix1398-141316
α-helix1421-14233
α-helix1424-143613
α-helix1439-14413
α-helix1445-145814
α-helix1463-148321
α-helix1487-14915
α-helix1492-14965
β-strand1564-156523
β-strand1569-157354
β-strand1578-158035
α-helix1772-17754
β-strand1777-178045
β-strand1788-179474
β-strand1800-180673
β-strand1812-182094
α-helix1824-18274
β-strand1829-183464
β-strand1842-184433
β-strand1855-186284
α-helix18631
β-strand1871-187445
β-strand1877-188153
α-helix1886-18894
α-helix1912-194029
α-helix1950-19578
α-helix1961-199737
α-helix2012-20176
α-helix2020-203920
α-helix2056-20627
α-helix2063-20675
α-helix2072-208615
α-helix2092-210413
α-helix2114-212714
α-helix2132-214615
α-helix2165-218117
α-helix2200-22034
α-helix2326-234116
β-strand234716
α-helix2348-236417
α-helix2371-23744
α-helix2377-238812
β-strand238917
β-strand239418
β-strand239718
α-helix2401-241919
β-strand256814
α-helix2569-25724
α-helix2577-259822
α-helix2636-264813
β-strand265517
α-helix2657-266812
α-helix2690-26923
α-helix2695-26962
α-helix2698-271013
α-helix2716-273015
α-helix2748-27547
α-helix2756-276712
β-strand277719
α-helix2782-280120
α-helix2805-282016
α-helix2825-28284
α-helix2833-284412
β-strand2852110
α-helix2853-287220
β-strand2877-2879311
α-helix2886-28883
α-helix2915-293016
α-helix29321
β-strand2933112
β-strand2934113
β-strand2940110
β-strand2941113
β-strand2979112
α-helix2980-29867
α-helix2988-299912
α-helix3032-304615
α-helix3050-306112
α-helix3065-30673
α-helix3075-30773
α-helix3079-308810
α-helix3092-31009
α-helix3103-311715
β-strand3120114
α-helix3125-31328
β-strand3161-3162211
α-helix3164-31663
β-strand3168-3170311
α-helix3176-31783
α-helix3180-31834
α-helix3187-31893
β-strand3197-3200411
α-helix3201-32022
β-strand3207-32272111
α-helix3232-32343
β-strand3238-3244711
β-strand3251-3252211
α-helix32561
β-strand3257-3258211
β-strand3265-32831911
β-strand3290-33011211
α-helix3306-33083
α-helix3322-33254
α-helix3328-333912
α-helix3342-335211
α-helix3358-33669
α-helix3375-338612
α-helix3390-340112
α-helix3429-344012
α-helix3446-346520
α-helix3484-34874
α-helix3491-350515
α-helix3513-35164
α-helix3519-353113
α-helix35331
α-helix3537-355216
α-helix3554-356411
α-helix3607-361610
α-helix3620-362910
α-helix3631-364414
α-helix3680-369415
α-helix3697-37037
α-helix3709-371911
α-helix3753-377018
α-helix3775-378915
α-helix3807-38159
β-strand3821-3827715
α-helix3847-38493
β-strand3855-3861715
α-helix3866-38716
β-strand3966-3969415
α-helix3976-39783
α-helix3983-399210
α-helix3995-39962
β-strand4001-4007715
α-helix4064-40696
α-helix4070-40767
α-helix4079-40846
Chain B: 114 helices, 52 β-strands
ElementResiduesLengthSheet
α-helix1019-102911
β-strand1031-1033316
α-helix1037-10382
β-strand1039-1041317
β-strand1046-1048316
α-helix1051-10544
α-helix1061-10666
α-helix1070-10723
β-strand1074-1079616
α-helix10801
β-strand1089-1094617
β-strand1101-1109916
β-strand1120-1126717
α-helix1172-11765
β-strand1181-1187717
α-helix1188-11914
β-strand1192116
β-strand1199-1203516
α-helix1206-12094
β-strand1219-1226817
α-helix1292-12954
β-strand1298-1306916
α-helix13071
α-helix1314-132310
α-helix1325-133511
α-helix1340-13423
α-helix1346-136318
α-helix1377-13837
α-helix1385-139410
α-helix1398-141316
α-helix1421-14233
α-helix1424-143613
α-helix1439-14413
α-helix1445-145814
α-helix1463-148321
α-helix1487-14915
α-helix1492-14965
β-strand1564-1565218
β-strand1569-1573519
β-strand1578-1580320
α-helix1772-17754
β-strand1777-1780420
β-strand1788-1794719
β-strand1800-1806718
β-strand1812-1820919
α-helix1824-18274
β-strand1829-1834619
β-strand1842-1844318
β-strand1855-1862819
α-helix18631
β-strand1871-1874420
β-strand1877-1881518
α-helix1886-18894
α-helix1912-194029
α-helix1950-19578
α-helix1961-199737
α-helix2012-20176
α-helix2020-203920
α-helix2056-20627
α-helix2063-20675
α-helix2072-208615
α-helix2092-210413
α-helix2114-212714
α-helix2132-214615
α-helix2165-218117
α-helix2326-234116
β-strand2347114
α-helix2348-236417
α-helix2371-23744
α-helix2377-238812
β-strand2389121
β-strand2394122
β-strand2397122
α-helix2401-241919
β-strand2568119
α-helix2569-25724
α-helix2577-259822
α-helix2636-264813
β-strand2655121
α-helix2657-266812
α-helix2690-26923
α-helix2695-26962
α-helix2698-271013
α-helix2716-273015
α-helix2748-27547
α-helix2756-276712
β-strand2777111
α-helix2782-280120
α-helix2805-282016
α-helix2825-28284
α-helix2833-284412
β-strand2852123
α-helix2853-287220
β-strand2877-287939
α-helix2886-28883
α-helix2915-293016
α-helix29321
β-strand2933124
β-strand2934125
β-strand2940123
β-strand2941125
β-strand2979124
α-helix2980-29867
α-helix2988-299912
α-helix3032-304615
α-helix3050-306112
α-helix3065-30673
α-helix3075-30773
α-helix3079-308810
α-helix3092-31009
α-helix3103-311715
β-strand312016
α-helix3125-31328
β-strand3161-316229
α-helix3164-31663
β-strand3168-317039
α-helix3176-31783
α-helix3180-31834
α-helix3187-31893
β-strand3197-320049
α-helix3201-32022
β-strand3207-3227219
α-helix3232-32343
β-strand3238-324479
β-strand3251-325229
α-helix32561
β-strand3257-325829
β-strand3265-3283199
β-strand3290-3301129
α-helix3306-33083
α-helix3322-33254
α-helix3328-333912
α-helix3342-335211
α-helix3358-33669
α-helix3375-338612
α-helix3390-340112
α-helix3429-344012
α-helix3446-346520
α-helix3484-34874
α-helix3491-350515
α-helix3513-35164
α-helix3519-353113
α-helix35331
α-helix3537-355216
α-helix3554-356411
α-helix3607-361610
α-helix3620-362910
α-helix3631-364414
α-helix3680-369415
α-helix3697-37037
α-helix3709-371911
α-helix3753-377119
α-helix3775-378915
α-helix3807-38159
β-strand3821-3827726
α-helix3847-38493
β-strand3855-3861726
α-helix3866-38716
β-strand3966-3969426
α-helix3976-39783
α-helix3983-399210
α-helix3995-39962
β-strand4001-4007726
α-helix4064-40696
α-helix4070-40767
α-helix4079-40846

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Baculoviral IAP repeat-containing protein 6A, Bprotein4888Homo sapiensQ9NR09
Sequence of entity 1 (A, B), FASTA
>8E2D_1 Baculoviral IAP repeat-containing protein 6 (chains A, B)
MDYKDDDDKLAAANSSIDLISTSLYKKAGLTMVTGGGAAPPGTVTEPLPSVIVLSAGRKM
AAAAAAASGPGCSSAAGAGAAGVSEWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRG
TIKVIDGTSGATLQASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTA
LQTPVSKQDDVVQLELPVTEAQQLLSACLEKVDISSTEGYDLFITQLKDGLKNTSHETAA
NHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVASSVMDRLSYLLPSARPE
LGVGPGRSVDRSLMYSEANRRETFTSWPHVGYRWAQPDPMAQAGFYHQPASSGDDRAMCF
TCSVCLVCWEPTDEPWSEHERHSPNCPFVKGEHTQNVPLSVTLATSPAQFPCTDGTDRIS
CFGSGSCPHFLAAATKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGDPSSGVDS
RRPTLAWLEDSSSCSDIPKLEGDSDDLLEDSDSEEHSRSDSVTGHTSQKEAMEVSLDITA
LSILQQPEKLQWEIVANVLEDTVKDLEELGANPCLTNSKSEKTKEKHQEQHNIPFPCLLA
GGLLTYKSPATSPISSNSHRSLDGLSRTQGESISEQGSTDNESCTNSELNSPLVRRTLPV
LLLYSIKESDEKAGKIFSQMNNIMSKSLHDDGFTVPQIIEMELDSQEQLLLQDPPVTYIQ
QFADAAANLTSPDSEKWNSVFPKPGTLVQCLRLPKFAEEENLCIDSITPCADGIHLLVGL
RTCPVESLSAINQVEALNNLNKLNSALCNRRKGELESNLAVVNGANISVIQHESPADVQT
PLIIQPEQRNVSGGYLVLYKMNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDN
REDDCEEPIEDMQLTSKNGFEREKTSDISTLGHLVITTQGGYVKILDLSNFEILAKVEPP
KKEGTEEQDTFVSVIYCSGTDRLCACTKGGELHFLQIGGTCDDIDEADILVDGSLSKGIE
PSSEGSKPLSNPSSPGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVPPCWVEV
QQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQTDSNSWDEHVFELVLPKACMVGHVDFKFV
LNSNITNIPQIQVTLLKNKAPGLGKVNALNIEVEQNGKPSLVDLNEEMQHMDVEESQCLR
LCPFLEDHKEDILCGPVWLASGLDLSGHAGMLTLTSPKLVKGMAGGKYRSFLIHVKAVNE
RGTEEICNGGMRPVVRLPSLKHQSNKGYSLASLLAKVAAGKEKSSNVKNENTSGTRKSEN
LRGCDLLQEVSVTIRRFKKTSISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQ
SLVLDTLCWLAGVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSIAHKCARFLA
LCISNGKCDPCQPAFGPVLLKALLDNMSFLPAATTGGSVYWYFVLLNYVKDEDLAGCSTA
CASLLTAVSRQLQDRLTPMEALLQTRYGLYSSPFDPVLFDLEMSGSSCKNVYNSSIGVQS
DEIDLSDVLSGNGKVSSCTAAEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDAMSSFG
VTPAVGGLSSGTVGEASTALSSAAQVALQSLSHAMASAEQQLQVLQEKQQQLLKLQQQKA
KLEAKLHQTTAAAAAAASAVGPVHNSVPSNPVAAPGFFIHPSDVIPPTPKTTPLFMTPPL
TPPNEAVSVVINAELAQLFPGSVIDPPAVNLAAHNKNSNKSRMNPLGSGLALAISHASHF
LQPPPHQSIIIERMHSGARRFVTLDFGRPILLTDVLIPTCGDLASLSIDIWTLGEEVDGR
RLVVATDISTHSLILHDLIPPPVCRFMKITVIGRYGSTNARAKIPLGFYYGHTYILPWES
ELKLMHDPLKGEGESANQPEIDQHLAMMVALQEDIQCRYNLACHRLETLLQSIDLPPLNS
ANNAQYFLRKPDKAVEEDSRVFSAYQDCIQLQLQLNLAHNAVQRLKVALGASRKMLSETS
NPEDLIQTSSTEQLRTIIRYLLDTLLSLLHASNGHSVPAVLQSTFHAQACEELFKHLCIS
GTPKIRLHTGLLLVQLCGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLLSCIGQRSL
SNSGVLESLLNLLDNLLSPLQPQLPMHRRTEGVLDIPMISWVVMLVSRLLDYVATVEDEA
AAAKKPLNGNQWSFINNNLHTQSLNRSSKGSSSLDRLYSRKIRKQLVHHKQQLNLLKAKQ
KALVEQMEKEKIQSNKGSSYKLLVEQAKLKQATSKHFKDLIRLRRTAEWSRSNLDTEVTT
AKESPEIEPLPFTLAHERCISVVQKLVLFLLSMDFTCHADLLLFVCKVLARIANATRPTI
HLCEIVNEPQLERLLLLLVGTDFNRGDISWGGAWAQYSLTCMLQDILAGELLAPVAAEAM
EEGTVGDDVGATAGDSDDSLQQSSVQLLETIDEPLTHDITGAPPLSSLEKDKEIDLELLQ
DLMEVDIDPLDIDLEKDPLAAKVFKPISSTWYDYWGADYGTYNYNPYIGGLGIPVAKPPA
NTEKNGSQTVSVSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALTNTSPTLSQSP
TGTDDSLLGGLQAANQTSQLIIQLSSVPMLNVCFNKLFSMLQVHHVQLESLLQLWLTLSL
NSSSTGNKENGADIFLYNANRIPVISLNQASITSFLTVLAWYPNTLLRTWCLVLHSLTLM
TNMQLNSGSSSAIGTQESTAHLLVSDPNLIHVLVKFLSGTSPHGTNQHSPQVGPTATQAM
QEFLTRLQVHLSSTCPQIFSEFLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFE
VVSVSTISAVIESVTFLVHHYITCSDKVMSRSGSDSSVGARACFGGLFANLIRPGDAKAV
CGEMTRDQLMFDLLKLVNILVQLPLSGNREYSARVSVTTNTTDSVSDEEKVSGGKDGNGS
STSVQGSPAYVADLVLANQQIMSQILSALGLCNSSAMAMIIGASGLHLTKHENFHGGLDA
ISVGDGLFTILTTLSKKASTVHMMLQPILTYMACGYMGRQGSLATCQLSEPLLWFILRVL
DTSDALKAFHDMGGVQLICNNMVTSTRAIVNTARSMVSTIMKFLDSGPNKAVDSTLKTRI
LASEPDNAEGIHNFAPLGTITSSSPTAQPAEVLLQATPPHRRARSAAWSYIFLPEEAWCD
LTIHLPAAVLLKEIHIQPHLASLATCPSSVSVEVSADGVNMLPLSTPVVTSGLTYIKIQL
VKAEVASAVCLRLHRPRDASTLGLSQIKLLGLTAFGTTSSATVNNPFLPSEDQVSKTSIG
WLRLLHHCLTHISDLEGMMASAAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQS
TRIGLKLIDILLRNCAASGSDPTDLNSPLLFGRLNGLSSDSTIDILYQLGTTQDPGTKDR
IQALLKWVSDSARVAAMKRSGRMNYMCPNSSTVEYGLLMPSPSHLHCVAAILWHSYELLV
EYDLPALLDQELFELLFNWSMSLPCNMVLKKAVDSLLCSMCHVHPNYFSLLMGWMGITPP
PVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQAPLALTESHLATLASSSQSPEAIKQLLDS
GLPSLLVRSLASFCFSHISSSESIAQSIDISQDKLRRHHVPQQCNKMPITADLVAPILRF
LTEVGNSHIMKDWLGGSEVNPLWTALLFLLCHSGSTSGSHNLGAQQTSARSASLSSAATT
GLTTQQRTAIENATVAFFLQCISCHPNNQKLMAQVLCELFQTSPQRGNLPTSGNISGFIR
RLFLQLMLEDEKVTMFLQSPCPLYKGRINATSHVIQHPMYGAGHKFRTLHLPVSTTLSDV
LDRVSDTPSITAKLISEQKDDKEKKNHEEKEKVKAENGFQDNYSVVVASGLKSQSKRAVS
ATPPRPPSRRGRTIPDKIGSTSGAEAANKIITVPVFHLFHKLLAGQPLPAEMTLAQLLTL
LYDRKLPQGYRSIDLTVKLGSRVITDPSLSKTDSYKRLHPEKDHGDLLASCPEDEALTPG
DECMDGILDESLLETCPIQSPLQVFAGMGGLALIAERLPMLYPEVIQQVSAPVVTSTTQE
KPKDSDQFEWVTIEQSGELVYEAPETVAAEPPPIKSAVQTMSPIPAHSLAAFGLFLRLPG
YAEVLLKERKHAQCLLRLVLGVTDDGEGSHILQSPSANVLPTLPFHVLRSLFSTTPLTTD
DGVLLRRMALEIGALHLILVCLSALSHHSPRVPNSSVNQTEPQVSSSHNPTSTEEQQLYW
AKGTGFGTGSTASGWDVEQALTKQRLEEEHVTCLLQVLASYINPVSSAVNGEAQSSHETR
GQNSNALPSVLLELLSQSCLIPAMSSYLRNDSVLDMARHVPLYRALLELLRAIASCAAMV
PLLLPLSTENGEEEEEQSECQTSVGTLLAKMKTCVDTYTNRLRSKRENVKTGVKPDASDQ
EPEGLTLLVPDIQKTAEIVYAATTSLRQANQEKKLGEYSKKAAMKPKPLSVLKSLEEKYV
AVMKKLQFDTFEMVSEDEDGKLGFKVNYHYMSQVKNANDANSAARARRLAQEAVTLSTSL
PLSSSSSVFVRCDEERLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTG
GHSVRFNPNLYNDGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLILVAEPYFNEP
GYERSRGTPSGTQSSREYDGNIRQATVKWAMLEQIRNPSPCFKEVIHKHFYLKRVEIMAQ
CEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLREELLKLPCPEGLDPDTDDAPEVCR
ATTGAEETLMHDQVKPSSSKELPSDFQL

Primary citation

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Hunkeler, M., Jin, C.Y., Fischer, E.S. Science (2023) 379:1105-1111. DOI 10.1126/science.ade5750 · PubMed

Other PDB entries of the same protein (UniProt Q9NR09), best resolution first:

Browse structure collections

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