8GHA: Hir3 Arm/Tail, Hir2 WD40, C-terminal Hpc2

Hir3 Arm/Tail, Hir2 WD40, C-terminal Hpc2. Determined by electron microscopy at 6.8 Å resolution. Released 10 Jul 2024.

Method
Electron microscopy
Resolution
6.8 Å
Organism
Saccharomyces cerevisiae
Chains
3
Atoms
9,783
Mol. weight
358.35 kDa
Released
10 Jul 2024

Explore 8GHA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8GHA contains 62 α-helices and 47 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain B: 8 helices, 35 β-strands

ElementResiduesLengthSheet
β-strand2-761
β-strand17-2158
β-strand24-2858
β-strand33-3868
α-helix39-468
β-strand59-6248
β-strand71-7669
β-strand80-8569
β-strand88-9369
β-strand96110
β-strand103110
α-helix104-1052
β-strand110-11679
β-strand122-129811
β-strand134-140711
β-strand144-149611
β-strand155-160611
β-strand167-172612
β-strand178-183612
β-strand187-192612
β-strand201-206612
β-strand209113
β-strand21713
β-strand226-23054
β-strand232113
α-helix2371
β-strand243-24864
β-strand255-26064
α-helix2661
β-strand267-27263
β-strand276-281614
β-strand286-290514
β-strand292-29763
β-strand303-30753
β-strand313-31863
β-strand325-33061
β-strand336-34161
β-strand345-35061
α-helix353-3564
β-strand358-360314
α-helix3611
α-helix362-3709
α-helix373-3786
Chain D: 45 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix905-92420
α-helix929-9324
α-helix933-94210
α-helix948-96013
α-helix985-99915
α-helix1015-102511
α-helix1028-10292
α-helix1034-104815
α-helix1053-10608
α-helix1076-10805
α-helix1083-110018
α-helix1106-11083
α-helix1109-112012
α-helix1127-114721
α-helix1149-11535
α-helix1155-118127
α-helix1187-120822
α-helix1215-12173
β-strand1218-121925
β-strand1225-122956
α-helix12301
β-strand1235-123956
α-helix1240-12423
β-strand1243-124425
α-helix1248-127225
α-helix1281-129010
α-helix1299-13024
α-helix1306-131510
α-helix1324-133916
α-helix1345-135410
α-helix1356-13594
α-helix1374-139421
α-helix1402-14109
α-helix1411-14155
α-helix1419-142911
β-strand143017
β-strand144017
α-helix1456-147116
α-helix1475-148511
α-helix1494-151320
α-helix1517-15193
α-helix1520-15245
α-helix1525-15273
α-helix1530-154314
α-helix1546-15483
α-helix1551-156616
α-helix1570-15723
α-helix1573-15808
α-helix1581-15855
α-helix1586-15916
α-helix1634-164714
Chain E: 9 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix425-4273
α-helix429-4324
α-helix434-4374
β-strand438-44361
α-helix4501
β-strand451-45551
β-strand45912
α-helix4651
β-strand46612
α-helix4671
β-strand474-47633
α-helix477-4859
α-helix492-50716
α-helix578-58912
β-strand595-59734

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Histone promoter control protein 2Eprotein625Saccharomyces cerevisiaeQ01448 (AlphaFold model)
Histone transcription regulator 3Dprotein1648Saccharomyces cerevisiaeP47171 (AlphaFold model)
Protein HIR2Bprotein875Saccharomyces cerevisiaeP32480 (AlphaFold model)
Sequence of entity 1 (E), FASTA
>8GHA_1 Histone promoter control protein 2 (chains E)
MDQKAIVLDNSKSGSKQTKSSGKMQTQTDTNAEVLNTDNSIKKETGSDSEDLFNKFSNKK
TNRKIPNIAEELAKNRNYVKGASPSPIIISGSSSTSPSGPSSSSTNPMGIPTNRFNKNTV
ELYQHSPSPVMTTNKTDTEEKRQNNRNMDNKNTPERGSSSFAAKQLKISSLLTISSNEDS
KTLHINDTNGNKNSNAASNNIPSAYAELHTEGNSIESLIKPPSSPRNKSLTPKVILPTQN
MDGTIAKDPHLGDNTPGILIAKTSSPVNLDVESTAQSLGKFNKSTNSLKAALTKAPAEKV
SLKRSISSVTNSDSNISSSKKPTSEKAKKSSSASAILPKPTTTKTSKKAASNSSDSTRKK
NASNKTTSAIKKESNAGSKLNTVKKENSSLSSIKATEKEKDKGGNSTEAKNSTSNVRKEP
TAKSPKRLVAAPTVSPPKILQTAETKAKEPSILIDVPLYQADTNDYLDENGQVIFNLSTL
IKEKYHPKSKELAQLKDSKRNLLMQLSDHSNGSLEKEKDEEGDVIELDDDEDMEEDEGEI
DTETNTVTTTISPKKKSHPMKGKNLIGKYDVEDPFIDDSELLWEEQRAATKDGFFVYFGP
LIEKGHYASLERANGTMKRGGVKNK
Sequence of entity 2 (D), FASTA
>8GHA_2 Histone transcription regulator 3 (chains D)
MSMFNALNSNIEGEQYEAEEHSRELQIEQSFNILQDALIDLKNKDFEKSDSKFQELFQID
VVKPDRWGMYRNSSPTLDNLRYLCYRNRGMYYHLYLENNYERLNSQELVNCILKAVENLV
ESIQHSDADFAVTDLLARIFKSFNSVKLERLISEYEFTKQENLSLLLGRHRKFLLNDLTL
MMNNYVELTNKLLVPNLSDNTIFERYHLEKYKDIKPEPLAFGPILSRISEMKKQDEEIMK
KLDVFNVTLNEESWDEVAKALKNLLPSVKTSSLIGRNMDPYNEIEEPIEAVKFELSEAIN
NTPSLDRESERQEEEQDNESVRADDKSGNLAPSDIQTNEEARPNKRTDEHIDSTKPLQRS
SKRFKEREQENSKELVMDVHKRFFGEFNTLLSYIHILPFCDFDTFASKFIIGSSDKQPEK
FIPYTDLYECLKSWSSRYTDIFNQNDYLSSGSNENEELFQLNALLKSNAFDDKESFPRYL
NDLDSDHIRSFISEVNAGNLHFHQVRLKLLFKLLGTYDEGNGRRLIIDYLWESQLLKIVL
WFVFGIESNIFALINKNKRQCKYLALSIYELLVNHLGNIVEEITNKRIQGHKSADLKSQR
NKVEKRIRSWHTLLEQIADEKDKELYVHFQWTHYCFLQYTCDIVDSRLSETLTSLENTIK
DSDSSLDIAYPNYRHIPALNLNTVQSQKRKIRIIQNITVEDISEDTNSDTHSENHLETLE
KVLLHILHPSTNHSNIDEEMVSFIFNSPFLLKIRLWGVLFSSYVKKSSIQDVQRIYFHVL
DFMKGALTSPVYKESNPHGRHQMLLTVLTAIGYLSSQLTAILNSNRWESSDFVLEDYMFE
KLLQTFFFFYTVLFYESSAVNDVSNKSFFKRASKSSGKMKDIMIDLATLILYYYDLQAKL
RTPAEQGIETTELIWSLHTLFGHFHFCDASNGKFLDLAEKLLCQFINNDSFLQLKQILWC
RYHYAIASDNFSPDLHDTKAVEMEKIHSLPLGTYLIKLQYQNKNPYLSSSKTTLKQIMDN
IIEKIGDPSTLDNHIISRNSFLLNEYLSRPITADLLKHTFSGATSLYLTSPNDELQQGMT
AGLFYVSSLQSLGLYKMRKKSMQARPSELDSIIRMLKNDIIYNTNRFESWILLGKCYSYI
VEDDLIWTSDKITVPEKKDVIALTQRKAILCYLMAISIYYSKLDRTIDDKKIILEALDDL
GSMLISGYYNPMNKLCFSWKSSAENTMRLSETGEVVMEKTKKITTISDFNIEQSIFLCFN
RACSLSGDIKSQDDVFVLNWSSFYNLAKFFFKTDGGNNCKLVAKYITQGCQIAYESSPAK
DPIIEPHYLLVNACYKWVKRGVIGVNEALTLLSKDNQFFQEQEEFWVNDEGLAWDYQEKF
FFDKIIRLLRHLLSVDKKKWQHRPRYRIARILFDDLGDVNGALEEMDSLISAKSINKNLV
NIWKPDFERPGKHFIYTYQYLVLYLDLLFAIKDFNTTGLVIKKLRRFGSGTVNVNELLER
AINVYTQSAKIKLQLQDKSYVEQILPTLNYQEFLKISEQLNQVFDQGKYPEEISSGLKLA
FQLKKGHSGIAFDSVCLGIYFEYLYFPLARQDQSLTDVNDENNPALPSSGSVTSKSTPDP
TSKPSAIKKRVTKKEVFDRVRLLVDKIT
Sequence of entity 3 (B), FASTA
>8GHA_3 Protein HIR2 (chains B)
MRLLKYPLDIHNEQVNALAALGPYIILAGSGGHVMAWRQQQLVDTAFDRVMIKDLKPEVS
FQVDQDTTGDIFFITGDLETLYIGSEHRLWGYSGWLCRDTNNINSVEKMNSKLLFECKSP
STITDVKYDINLGILFVLLSNENKILLFRHKTFDKLSEITIDKASKPITGIIDPTGQTFT
VMTSDRSILVYQINKTGTHKLINKLTQHVQMYPLHYRISMSPQADILPVINSVKGVPNNA
TSCTALLDRNNNYKVTKTLVTPSSNGCRVLVYSPAFYEKPNLKKGTSTRYNLIATSGSTD
GTILVWNTKRMKPLFNALQVSSTAINDMSWSQDGFTLFAISNDATLYTFAFQEKDLGVAL
PQTEIKSLQEVNKKLPKLEEPLAEQIPKSFPENIKLEESASAAPIPNDIGRSAVGKKPTK
KKTANNQTNGIKTIQSTSMEFNTPSYTVPRDLKRKPKEATPSNIAPGSKKQKKELQPIDF
LDTGLLLPNTSFSRIRLATPKIRSTFKYSPINNPNLILDVKNGSGNEQRPTIVKLTSKVL
DQDQVLFQDFIPKLITICTAGDTFWSFCSEDGSIYIYSDSGRKLMAPLVLGVSISFLEAC
GTYLLCLTSIGELYCWNIEQKKLAFPTNTIYPLLNPSLRYSDDILTRAENITLCSITKKG
VPLVTLSNGDGYLFDKNMETWLLVSDGWWAYGSQYWDTTNTTGLSSSKANTDSFNGSESN
INEIVSDIKNDNQSIINFLECKTNDELNRKGRIKNLQRFARTILMKEGFENMEEIVTLSH
LENKILISIRLEEPEEFSKLMMVYCIRLSELGYMDRLNDVFQWLYDDLPISGTGSAFADK
DFKRNLLKKILIACGDIRQVQRVTTRYAKEMNIIS

Primary citation

Structure of the Hir histone chaperone complex. Kim, H.J., Szurgot, M.R., van Eeuwen, T. et al. Mol Cell (2024) 84:2601-2617.e12. DOI 10.1016/j.molcel.2024.05.031 · PubMed

Other PDB entries of the same protein (UniProt Q01448 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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