8H0V: RNA polymerase II transcribing a chromatosome

Name: PDB 8H0V: RNA polymerase II transcribing a chromatosome (type I)
Published: 2022-12-07
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

RNA polymerase II transcribing a chromatosome (type I). Determined by electron microscopy at 3.8 Å resolution. Released 7 Dec 2022.

Method: Electron microscopy
Resolution: 3.8 Å
Organisms: Komagataella phaffii, synthetic construct, Homo sapiens
Chains: 24
Atoms: 46,571
Mol. weight: 810.89 kDa
Ligands: MG, ZN
Released: 7 Dec 2022

Explore 8H0V in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8H0V contains 235 α-helices and 265 β-strands across 21 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 5 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	41-42	2
α-helix	45-56	12
α-helix	64-75	12
β-strand	83-84	2	79
α-helix	86-113	28
β-strand	118-119	2	80
α-helix	121-131	11

Chain A: 84 helices, 70 β-strands

Element	Residues	Length	Sheet
α-helix	10	1
β-strand	11	1	1
β-strand	16-18	3	2
β-strand	21	1	3
α-helix	22-23	2
α-helix	24-30	7
β-strand	34	1	4
α-helix	48-49	2
α-helix	56-58	3
β-strand	82-91	10	4
α-helix	93-95	3
α-helix	96-105	10
β-strand	106	1	5
β-strand	113	1	5
α-helix	120-125	6
α-helix	131-142	12
β-strand	147	1	6
β-strand	151	1	7
β-strand	164	1	7
α-helix	170	1
β-strand	171	1	6
α-helix	172-173	2
β-strand	174-178	5	8
β-strand	181-186	6	8
β-strand	199-203	5	8
α-helix	205-213	9
α-helix	217-223	7
α-helix	232-235	4
β-strand	236-242	7	4
α-helix	245-247	3
β-strand	251-252	2	9
β-strand	258-259	2	9
α-helix	262-277	16
α-helix	290-305	16
α-helix	313-315	3
β-strand	316	1	10
α-helix	321	1
β-strand	322	1	10
α-helix	323	1
α-helix	326-330	5
α-helix	336	1
α-helix	337-341	5
β-strand	344-346	3	11
β-strand	349-356	8	12
β-strand	364-368	5	12
α-helix	369-374	6
β-strand	376-380	5	13
α-helix	386-395	10
β-strand	403-407	5	13
β-strand	413-415	3	13
α-helix	422-424	3
α-helix	427-428	2
β-strand	432-436	5	13
β-strand	442-446	5	12
α-helix	453-455	3
β-strand	456-464	9	12
β-strand	469-471	3	12
α-helix	473-476	4
β-strand	487-491	5	12
α-helix	496-501	6
α-helix	502-506	5
β-strand	507	1	12
α-helix	508-511	4
β-strand	513	1	14
β-strand	520	1	14
α-helix	528-535	8
β-strand	541-542	2	15
α-helix	544-553	10
α-helix	561-564	4
β-strand	566-568	3	16
β-strand	572	1	16
β-strand	573-574	2	15
α-helix	575-582	8
α-helix	584	1
β-strand	589-591	3	17
β-strand	606-609	4	17
β-strand	612-615	4	17
α-helix	620-623	4
α-helix	630-638	9
α-helix	640-661	22
β-strand	664	1	18
α-helix	667-670	4
α-helix	674-699	26
α-helix	711-737	27
α-helix	743-750	8
α-helix	756-759	4
α-helix	760-764	5
β-strand	767-768	2	19
β-strand	771	1	20
β-strand	774	1	20
β-strand	780	1	21
β-strand	783	1	21
β-strand	800-801	2	19
α-helix	811-846	36
β-strand	850-851	2	22
β-strand	857-858	2	22
β-strand	864-866	3	22
α-helix	869-871	3
β-strand	874	1	23
β-strand	880-883	4	24
α-helix	891-898	8
α-helix	911-913	3
β-strand	914	1	25
α-helix	917-920	4
α-helix	927-943	17
α-helix	944-948	5
β-strand	955-958	4	24
α-helix	962-973	12
α-helix	979-980	2
β-strand	981	1	25
α-helix	985-996	12
α-helix	1007-1016	10
α-helix	1018-1027	10
α-helix	1030-1031	2
α-helix	1032-1036	5
α-helix	1041-1057	17
β-strand	1059	1	23
α-helix	1060-1061	2
α-helix	1066-1078	13
α-helix	1099-1107	9
β-strand	1118-1120	3	26
α-helix	1121	1
β-strand	1122	1	27
α-helix	1123	1
α-helix	1124-1128	5
α-helix	1130-1140	11
β-strand	1143-1144	2	28
α-helix	1145-1148	4
β-strand	1151-1156	6	29
α-helix	1169-1173	5
β-strand	1193-1198	6	29
α-helix	1201-1206	6
α-helix	1211-1221	11
β-strand	1227-1230	4	29
β-strand	1239-1243	5	29
α-helix	1262-1273	12
β-strand	1275-1277	3	28
β-strand	1284-1295	12	26
β-strand	1301-1312	12	26
α-helix	1316-1321	6
β-strand	1325	1	27
β-strand	1331-1332	2	26
α-helix	1335-1342	8
α-helix	1344-1360	17
α-helix	1368-1378	11
α-helix	1389-1392	4
α-helix	1399-1405	7
α-helix	1408-1418	11
β-strand	1421-1422	2	2
α-helix	1427-1432	6
α-helix	1440-1442	3
β-strand	1444-1448	5	30
α-helix	1453-1455	3
α-helix	1458-1460	3

Chains b and f: 4 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	26-28	3
α-helix	31-40	10
β-strand	45-46	2	80
α-helix	50-75	26
β-strand	80-81	2	79
α-helix	83-92	10
β-strand	97-98	2	81

Chain B: 54 helices, 88 β-strands

Element	Residues	Length	Sheet
α-helix	14-28	15
α-helix	32-40	9
α-helix	41-45	5
α-helix	46-52	7
β-strand	55-60	6	31
β-strand	72-84	13	31
β-strand	88-90	3	32
β-strand	96-98	3	32
α-helix	101-106	6
β-strand	112-126	15	31
β-strand	155-162	8	31
β-strand	164	1	33
α-helix	177-182	6
β-strand	194-196	3	33
β-strand	199-203	5	33
α-helix	204	1
β-strand	205-209	5	34
β-strand	215-218	4	35
β-strand	225-230	6	35
β-strand	232-234	3	36
β-strand	241-244	4	36
β-strand	246-250	5	35
β-strand	252	1	37
β-strand	255	1	37
β-strand	261-264	4	35
α-helix	271-272	2
β-strand	273	1	35
α-helix	274-280	7
α-helix	286-293	8
α-helix	301-312	12
α-helix	319-327	9
α-helix	338-350	13
α-helix	364-382	19
α-helix	387-390	4
α-helix	394-396	3
β-strand	397-400	4	34
α-helix	402-428	27
α-helix	429-431	3
α-helix	444-456	13
β-strand	459	1	38
α-helix	462-464	3
β-strand	469	1	38
β-strand	473-475	3	33
α-helix	481-487	7
β-strand	490-492	3	34
α-helix	509-511	3
β-strand	515	1	39
α-helix	523-525	3
β-strand	529-531	3	34
β-strand	532	1	39
β-strand	533	1	40
β-strand	537-538	2	41
α-helix	545-554	10
α-helix	556	1
β-strand	557	1	42
α-helix	558	1
α-helix	559-561	3
α-helix	570	1
β-strand	571-575	5	42
β-strand	578-583	6	42
α-helix	586-599	14
β-strand	607-611	5	42
β-strand	616-620	5	42
β-strand	626-632	7	41
β-strand	633	1	43
β-strand	645	1	43
α-helix	649-657	9
α-helix	678-683	6
β-strand	687-691	5	41
α-helix	692-695	4
β-strand	700-701	2	41
α-helix	704-707	4
β-strand	740-741	2	41
α-helix	745-748	4
β-strand	750	1	40
α-helix	753-755	3
α-helix	759-761	3
β-strand	762	1	44
α-helix	764-773	10
α-helix	774-776	3
β-strand	777	1	45
β-strand	779	1	46
β-strand	792-796	5	46
β-strand	800	1	47
β-strand	804-805	2	48
α-helix	809-812	4
β-strand	821-827	7	49
β-strand	828	1	18
β-strand	838-842	5	49
α-helix	843-847	5
β-strand	853-862	10	46
β-strand	865	1	50
β-strand	871	1	50
β-strand	873-874	2	51
β-strand	882-883	2	51
β-strand	893	1	52
β-strand	898	1	53
β-strand	899	1	52
α-helix	900	1
β-strand	904-905	2	46
β-strand	910-912	3	53
β-strand	914-917	4	51
α-helix	918-919	2
β-strand	934-936	3	51
β-strand	939-940	2	53
α-helix	941-942	2
β-strand	947-956	10	46
β-strand	962-972	11	46
β-strand	979-982	4	49
β-strand	987-994	8	49
β-strand	1001-1002	2	54
β-strand	1010-1012	3	49
α-helix	1014-1016	3
β-strand	1022	1	44
α-helix	1023-1038	16
α-helix	1041	1
β-strand	1042-1043	2	48
α-helix	1052-1061	10
β-strand	1069-1070	2	49
β-strand	1072-1073	2	54
α-helix	1079	1
β-strand	1080	1	54
α-helix	1081	1
β-strand	1085-1094	10	49
β-strand	1095	1	45
α-helix	1099-1101	3
β-strand	1104-1106	3	12
β-strand	1111	1	55
β-strand	1118	1	55
α-helix	1119	1
β-strand	1128-1130	3	11
α-helix	1132-1141	10
α-helix	1144-1151	8
β-strand	1157-1163	7	1
β-strand	1172-1174	3	56
β-strand	1179-1181	3	56
β-strand	1182	1	57
β-strand	1187	1	57
β-strand	1191-1197	7	1
α-helix	1198-1209	12
β-strand	1212	1	3
β-strand	1215-1217	3	2

Chain c: 5 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	17-20	4
α-helix	27-35	9
β-strand	42-43	2	82
α-helix	46-71	26
β-strand	77-78	2	83
α-helix	80-89	10
α-helix	91-96	6
β-strand	101-102	2	84

Chain C: 10 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	6-12	7	58
β-strand	16-22	7	58
α-helix	26-38	13
β-strand	42-53	12	59
α-helix	59-67	9
β-strand	71-73	3	60
α-helix	76-78	3
β-strand	96-103	8	59
β-strand	111-114	4	61
α-helix	115-117	3
β-strand	119-122	4	59
β-strand	129-132	4	60
α-helix	133	1
β-strand	143-147	5	61
β-strand	152-162	11	59
α-helix	168-170	3
β-strand	173-180	8	58
α-helix	202-204	3
α-helix	207-209	3
α-helix	211-214	4
β-strand	227-234	8	58
α-helix	240-263	24

Chains d and h: 4 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	35-45	11
β-strand	50-51	2	83
α-helix	53-80	28
β-strand	85-86	2	82
α-helix	88-98	11
α-helix	101-120	20

Chain D: 11 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	5-6	2	62
β-strand	24	1	63
α-helix	25-27	3
β-strand	29	1	63
β-strand	37-39	3	64
β-strand	45-47	3	64
α-helix	53-71	19
α-helix	86-89	4
α-helix	90-92	3
α-helix	96-111	16
α-helix	118-128	11
α-helix	139-147	9
α-helix	153-159	7
α-helix	161-166	6
α-helix	171-181	11
α-helix	182-184	3

11 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1743	Komagataella phaffii	C4R4Y0
DNA-directed RNA polymerase subunit beta	B	protein	1227	Komagataella phaffii	C4QZQ7 (AlphaFold model)
RNA polymerase II third largest subunit B44, part of central core	C	protein	304	Komagataella phaffii	C4R7L2 (AlphaFold model)
RNA polymerase II subunit B32	D	protein	186	Komagataella phaffii	C4R2U9 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	214	Komagataella phaffii	C4R3P8
RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III	F	protein	155	Komagataella phaffii	C4R1V1
RNA polymerase II subunit	G	protein	171	Komagataella phaffii	C4R9A1
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	145	Komagataella phaffii	C4R273
DNA-directed RNA polymerase subunit	I	protein	115	Komagataella phaffii	F2QPE6
RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III	J	protein	72	Komagataella phaffii	C4R009
RNA polymerase II subunit B12.5	K	protein	118	Komagataella phaffii	C4R3Z5
RNA polymerase subunit ABC10-alpha	L	protein	72	Komagataella phaffii	F2QMI1

8 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8H0V_1 DNA-directed RNA polymerase subunit (chains A)
MSQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREGGLNDPKLGS
IDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKKVCECICMNCGKLLLDETNP
TMAQAIRIRDPKKRFNAVWQLCKTKMVCEADAPVDEYSEQKVVSRGGCGNTQPVVRKDGM
KLWGTWKKSGFSDRDAQPERKLLTPGEILNVFKHISPEDCFRLGFNEDYARPEWMIITVL
PVPPPQVRPSIAMDETTQGQDDLTHKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFH
VATYMDNDIAGQPQALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNL
ELDQVGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRIDLRYHK
RAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMPYSTFRLNLSVTSPYN
ADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPVMGIVQDTLCGVRKMTLRDT
FIEYEQVMNMLFWVPSWDGVVPQPAILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLS
PKDNGMLIVDGKVMFGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLH
NGFSIGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRESFEGEVS
RTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSACVGQQMVEGKRIAFGF
ADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEFFFHAMAGREGLIDTAVKTAETGYIQR
RLVKALEDIMVHYDGTTRNSLGDIIQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYV
DLMDEKNSIKPDVIEYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPV
NLRRIIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQNATSLF
QCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEMVGVIAAQSIGEPATQ
MTLNTFHYAGVSSKNVTLGVPRLKEILNVAKNIKTPALTVYLDREIALDIEKAKVIQSSI
EYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSIPDEKVEETIDKQSPWLLRLELD
RARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLIIRCRVIRDPKAMDEELEAEED
QMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEYKNEELWALETDGINLAEVM
AVPGVDSSRTYSNSFVEILSVLGIEATRSSLYKEILNVIAFDGSYVNYRHMALLVDVMTS
RGYLMAITRHGINRADTGALMRCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMG
TGAFDVMIDEKLLTSLPADYAPTMPLFKGKATQGSATPYDNNAQYDDEFNHDDVADVMFS
PMAETGSGDDRSGGLTEYAGIQSPYQPTSPGLSATSPGFAPTSPGFAPTSPRYSPTSPGY
SPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTS
PSYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYS
PTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPTSPQYSPASPQYSPSRHSPNGESK
EGE

Sequence of entity 2 (B), FASTA

>8H0V_2 DNA-directed RNA polymerase subunit beta (chains B)
MSYDPYSIDDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLILDQ
PAQHTNEKDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYSSPVYLDME
KSMFTSIDDEGNPNATLDWQQVHEPIKDGVEEGNKVHIGKVPIMLRSKFCSLRTLDEVDL
YKMKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALEKGSR
LISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPDGEILQHICYDENDW
QMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGIRREKRIQYAKDILQKELLPHITQE
EGFETRKTFFLGYMVNRLLLCALERKDQDDRDHFGKKRLDLAGPLLANLFRILFRKLTRE
IYRYMQRCIETDRDFNLNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYT
YSSTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLSGISI
GSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDPSMLVSTMRDLRRSG
AISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDDESKDNKGELRITKEHIRKIQQGYD
DDAMNDDSEEQEQDVYGWSSLVTSGVIEYVDGEEEETIMIAMTPEDLQTRSLEQKEIDLN
DTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGV
FLTNYNVRMDTMANILYYPQKPLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMI
MNQSSIDRGLFRSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIA
PGVRVSGDDIIIGKTTPIPPDTEELGQRTKYHTKRDASTPLRSTENGIVDQVLLTTNQEG
LKFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLIINPHAIPSR
MTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRDNGYQSRGFEVMYNGHTGKK
LMAQVFFGPTYYQRLRHMVDDKIHARARGPVQVLTRQPVEGRSRDGGLRFGEMERDCMIA
HGAAGFLKERLMEASDAFRVHVCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAA
KLLFQELMAMNIAPRLYTERSGVSMRS

Sequence of entity 3 (C), FASTA

>8H0V_3 RNA polymerase II third largest subunit B44, part of central core (chains C)
MSKEPKVNIINAQDDEVELMLSDVNLSLANSLRRTMLAEVPTLAIDLVEIKMNTSVLADE
FISHRLGLIPLVSEDVEEMKYSRDCTCEDYCDECSVVLELSARHEGEEGTTDVYSSSLIK
VSGPGNLNVGEPVRRDDYDQGILLCKLRNHQELNIRCIAKKGIAKEHAKWSPCSAIAFEY
DPHNKLKHTDFWFEVDAKKEWPDSKYATWEEPPKPGEVFDYKAKPNRFYMTVETTGSLKA
NQVFSRGIKTLQEKLANVLFELENSRPANTTAYGGATAYGGQTVYGRETSYGGNTNYGDY
NAPY

Sequence of entity 4 (D), FASTA

>8H0V_4 RNA polymerase II subunit B32 (chains D)
MNVSTSTVGARRRRAKQQVDDEENATLLRLGPEFALKQYDHDGNEHDLIALSLSESRLLI
REALKARSRARNGGVDIESSNGEIDDDELAKVTSGAVANGVVKKTLDYLNTFARFKDEET
CTAVDQLLHNSSDCSVLHPFEIAQLSSLGCEDVDEAITLIPSLAAKKEVNLQRILDELNR
LEDPYK

Sequence of entity 5 (E), FASTA

>8H0V_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MEDNNRIISRLWRSFRTVKEMAADRGYFISQEEMDQSLEEFRSKICDSMGNPQRKLMSFL
ANPTPEALEKYSDLGTLWVEFCDEPSVGIKTMRNFCLRIQEKNFSTGIFIYQNNITPSAN
KMIPTVSPAIIETFQESDLVVNITHHELVPKHIRLSDGEKSQLLQRYKLKESQLPRIQRE
DPVARYLGLKRGQVVKIIRRSETSGRYASYRICL

Sequence of entity 6 (F), FASTA

>8H0V_6 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III (chains F)
MSEDEAFNEQTENFENFEDEHFSDDNFEDRSTQPEDYAVGVTADGRQIINGDGIQEVNGT
IKAHRKRSNKELAILKEERTTTPYLTKYERARILGTRALQISMNAPVLVDIEGETDPLQI
AMKELSQRKIPLVIRRYLPDGSYEDWGCDELIVDN

Sequence of entity 7 (G), FASTA

>8H0V_7 RNA polymerase II subunit (chains G)
MFFLKDLSLILTLHPSYFGPQMNQYLREKLLTDVEGTCTGQFGYIVTVLDGMNIDVGKGR
IIPGSGSAEFEVKYRAVVWKPFKGEVVDAIVSNVSPIGFFADVGPLNVFVSTRLIPDNLV
YNPSNSPPAYMSNDELITKGSKVRLKVVGTRTDVNEIYAIGSIKEDFLGAI

Sequence of entity 8 (H), FASTA

>8H0V_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MSSALFDDIFTVQTVDNGRYNKVSRIIGISTTNSAIKLTLDINNEMFPVSQDDSLTVTLA
NSLSLDGEDESANFSKSWRPPKPTDKSLADDYDYVMFGTVYKFEEGDEDKIKVYVSFGGL
LMCLEGGYKSLASLKQDNLYILIRR

Sequence of entity 9 (I), FASTA

>8H0V_9 DNA-directed RNA polymerase subunit (chains I)
MASFRFCLECNNMLYPKEDKENQRLLYSCRNCDYTELAEDPKVYRHELITNIGETAGIVD
DIGQDPTLPRSDKECPECHSRDCVFFQSQQRRKDTNMTLFYVCLNCKKTFRDESE

Sequence of entity 10 (J), FASTA

>8H0V_10 RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III (chains J)
MIIPVRCFSCGKVVGDKWDAYLRLLEEGKQEGDALDELKLKRYCCRRMVLTHVDLIEKFL
RYNPLEKKDFDS

Sequence of entity 11 (K), FASTA

>8H0V_11 RNA polymerase II subunit B12.5 (chains K)
MNAPDRFELFILPDDVPKLKITPDSRVPNCIIIKFEREDHTLANLLREELALYPDVTFVA
YKVEHPLFANFVMRLQTEEGTRPKQALERACASIINKLKTLDHKFNEEWNIKNFSLND

Sequence of entity 12 (L), FASTA

>8H0V_12 RNA polymerase subunit ABC10-alpha (chains L)
MSREGFVAPSGTDLAAAASGVAPNKHYGVKYTCGACAHNFSLNKSDPVRCKECGHRVIYK
ARTKRMIQFDAR

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	8

Primary citation

Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Hirano, R., Ehara, H., Kujirai, T. et al. Nat Commun (2022) 13:7287-7287. DOI 10.1038/s41467-022-35003-z · PubMed

Other PDB entries of the same protein (UniProt C4R4Y0), best resolution first:

5XOG 3.0 Å, RNA Polymerase II elongation complex bound with Spt5 KOW5 and Elf1
7XN7 3.1 Å, RNA polymerase II elongation complex containing Spt4/5, Elf1, Spt6, Spn1 and Paf1C
8JH4 3.2 Å, RNA polymerase II elongation complex containing 60 bp upstream DNA loop, stalled at…
8YFQ 3.3 Å, Cryo EM structure of Komagataella phaffii RNAPII-Rat1-Rai1 pre-termination complex
7XSZ 3.4 Å, RNA polymerase II elongation complex transcribing a nucleosome (EC115)
8YFR 3.4 Å, Cryo EM structure of Komagataella phaffii Rat1-Rai1 complex bound within the RNAPII cleft
9WMS 3.4 Å, Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II…
9II7 3.5 Å, RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome containing…
9WMT 3.59 Å, Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II…
7XSE 3.6 Å, RNA polymerase II elongation complex transcribing a nucleosome (EC42)
9UJS 3.62 Å, RNA polymerase II elongation complex stalled at SHL(-4) of the H3-H4 octasome
9WMW 3.62 Å, Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II…

Browse structure collections

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